Ultra-violet Radiation Therapy in Erysipelas

Ude, Walter H.

doi:10.1148/13.6.504

Cited by 5 publications

(3 citation statements)

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“…He had a success rate of 98% in thousands of cases, mostly the form of cutaneous tuberculosis known as lupus vulgaris [5]. Walter H Ude reported a series of 100 cases of erysipelas (a cutaneous infection caused by Streptococcus pyogenes) in the 1920s, with high cure rates using irradiation of the skin with UV light [6]. …”

Section: Historical Introductionmentioning

confidence: 99%

Ultraviolet Irradiation of Blood: “The Cure That Time Forgot”?

Hamblin

2017

Advances in Experimental Medicine and Biology

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Ultraviolet blood irradiation (UBI) was extensively used in the 1940s and 1950s to treat many diseases including septicemia, pneumonia, tuberculosis, arthritis, asthma and even poliomyelitis. The early studies were carried out by several physicians in USA and published in the American Journal of Surgery. However with the development of antibiotics, UBI use declined and it has now been called “the cure that time forgot”. Later studies were mostly performed by Russian workers and in other Eastern countries and the modern view in Western countries is that UBI remains highly controversial. This chapter discusses the potential of UBI as an alternative approach to current methods used to treat infections, as an immune-modulating therapy and as a method for normalizing blood parameters. No resistance of microorganisms to UV irradiation has been reported, and multi- antibiotic resistant strains are as susceptible as their wild-type counterparts. Low and mild doses of UV kill microorganisms by damaging the DNA, while any DNA damage in host cells can be rapidly repaired by DNA repair enzymes. However the use of UBI to treat septicemia cannot be solely due to UV-mediated killing of bacteria in the blood-stream, as only 5–7% of blood volume needs to be treated with UV to produce the optimum benefit. UBI may enhance the phagocytic capacity of various phagocytic cells (neutrophils and dendritic cells), inhibit lymphocytes, and oxidize blood lipids. The oxidative nature of UBI may have mechanisms in common with ozone therapy and other oxygen therapies. There may be some similarities to extracorporeal photopheresis (ECP) using psoralens and UVA irradiation. However there are differences between UBI and ECP in that UBI tends to stimulate the immune system, while ECP tends to be immunosuppressive. With the recent emergence of bacteria that are resistant to all known antibiotics, UBI should be more investigated as an alternative approach to infections, and as an immune-modulating therapy.

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Section: Historical Introductionmentioning

confidence: 99%

Ultraviolet Irradiation of Blood: “The Cure That Time Forgot”?

Hamblin

2017

Advances in Experimental Medicine and Biology

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show abstract

“…He had a success rate of 98% in thousands of cases, mostly the form of cutaneous tuberculosis known as lupus vulgaris [5]. Walter H Ude reported a series of 100 cases of erysipelas (a cutaneous infection caused by Streptococcus pyogenes) in the 1920s, that were treated with high cure rates using UV skin irradiation [6]. …”

Section: Historical Introductionmentioning

confidence: 99%

Ultraviolet blood irradiation: Is it time to remember “the cure that time forgot”?

Hamblin

2016

Journal of Photochemistry and Photobiology B: Biology

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Ultraviolet blood irradiation (UBI) was extensively used in the 1940s and 1950s to treat many diseases including septicemia, pneumonia, tuberculosis, arthritis, asthma and even poliomyelitis. The early studies were carried out by several physicians in USA and published in the American Journal of Surgery. However with the development of antibiotics, the use of UBI declined and it has now been called “the cure that time forgot”. Later studies were mostly performed by Russian workers and in other Eastern countries, and the modern view in Western countries is that UBI remains highly controversial. This review discusses the potential of UBI as an alternative approach to current methods used to treat infections, as an immune-modulating therapy and as a method for normalizing blood parameters. Low and mild doses of UV kill microorganisms by damaging the DNA, while any DNA damage in host cells can be rapidly repaired by DNA repair enzymes. However the use of UBI to treat septicemia cannot be solely due to UV-mediated killing of bacteria in the bloodstream, as only 5–7% of blood volume needs to be treated with UV to produce the optimum benefit, and higher doses can be damaging. There may be some similarities to extracorporeal photopheresis (ECP) using psoralens and UVA irradiation. However there are differences between UBI and ECP in that UBI tends to stimulate the immune system, while ECP tends to be immunosuppressive. With the recent emergence of bacteria that are resistant to all known antibiotics, UBI should be more investigated as an alternative approach to infections, and as an immune-modulating therapy.

show abstract

“…His success rate was 98% in thousands of cases, mostly cutaneous tuberculosis known as lupus vulgaris. Walter Ude reported a series of 100 cases of erysipelas (a cutaneous infection caused by Streptococcus pyogenes ) in the 1920s, with high cure rates using irradiation of the skin with UV light ( Ude, 1929 ).…”

Section: Ultraviolet Blood Irradiation (Ubi)mentioning

confidence: 99%

Oxidation and “Unconventional” Approaches to Infection

Rowen¹

2022

Encyclopedia of Infection and Immunity

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Ultra-violet Radiation Therapy in Erysipelas

Cited by 5 publications

References 1 publication

Ultraviolet Irradiation of Blood: “The Cure That Time Forgot”?

Ultraviolet Irradiation of Blood: “The Cure That Time Forgot”?

Ultraviolet blood irradiation: Is it time to remember “the cure that time forgot”?

Oxidation and “Unconventional” Approaches to Infection

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