Therapeutic use of ozone is becoming increasingly prevalent worldwide. New methods of administration are emerging. One of these emerging techniques, which we refer to as ozone dialysis, uses a dialysis membrane that allows blood to flow against a countercurrent of ozone gas. We found that ozone uptake by continuous countercurrent blood flow is at least 3 times higher than any comparable form of blood ozone administration currently available. This is thefirst quantitative report of ozone uptake by blood using the ozone dialysis technique.