Ultra-small methionine-capped Au0/Au+ nanoparticles as efficient drug against the antibiotic-resistant bacteria

Žalnėravičius, Rokas; Mikalauskaitė, Agnė; Niaura, Gediminas; Paškevičius, Algimantas; Jagminas, Arūnas

doi:10.1016/j.msec.2019.04.062

Cited by 14 publications

(8 citation statements)

References 28 publications

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“…The author also mentioned in a different study that doped-IONPs combined with antibiotics discharged iron ions almost twice as much as bare IONPs at a pH of 5 in response to the formation of the galvanic couple with metal, leading to a higher antimicrobial activity . Doped-IONPs and bare IONPs shared similar mechanism of actions from generating ROS for disrupting the bacterial DNA and membrane, leading to cell death eventually. ,− ,,,,, …”

Section: Doped-iron Oxide Nanoparticles (Doped-ionps)mentioning

confidence: 98%

“…118 Doped-IONPs and bare IONPs shared similar mechanism of actions from generating ROS for disrupting the bacterial DNA and membrane, leading to cell death eventually. 25,[28][29][30][31][32]34,36,51,52,116…”

Section: Doped-iron Oxide Nanoparticles (Doped-ionps)mentioning

confidence: 99%

“…Doped-IONPs are composed of modified iron oxides by introducing foreign metals or elements into their structure. ,,,− Introduction of foreign metals, also known as dopants, into an empty crystal lattice alters the physicochemical, biological, electrical, as well as optical properties of the nanoparticles . Doped-IONPs can be synthesized by coprecipitation (CP), green combustion (GC), sol–gel process (SGP), chemical polymerization approach (CPA), microwave-assisted process (MAP), hydrothermal approach (HDA). ,,,,,− Multiple types of dopants, e.g. , cobalt, nickel, copper, zinc, and rare-earth elements are broadly applied for doping purposes. ,,,, At present, doped-IONPs have found widespread applications in drug delivery, antimicrobial and anticancer activities, MRI imaging agent. − Moreover, when doped-IONPs are employed as antimicrobial agents, transition metals are mainly utilized due to their antimicrobial characteristics in their bulk form …”

Section: Doped-iron Oxide Nanoparticles (Doped-ionps)mentioning

confidence: 99%

“…Similarly, the insertion of foreign metal particles into IONPs alter their physicochemical, as well as biological, electrical, and optical, properties and improve performance compared to bare IONPs . IONPs are doped with several metals, and their oxides, such as Ni, , Cu, , Co, Zn, , Se, Mo, Au, , ZnO, , CuO, exhibit antimicrobial activity toward pathogenic bacteria.…”

Section: Introductionmentioning

confidence: 99%

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The Promise of Metal-Doped Iron Oxide Nanoparticles as Antimicrobial Agent

Tasnim,

Ferdous,

Rumon

et al. 2023

ACS Omega

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Antibiotic resistance (AMR) is one of the pressing global public health concerns and projections indicate a potential 10 million fatalities by the year 2050. The decreasing effectiveness of commercially available antibiotics due to the drug resistance phenomenon has spurred research efforts to develop potent and safe antimicrobial agents. Iron oxide nanoparticles (IONPs), especially when doped with metals, have emerged as a promising avenue for combating microbial infections. Like IONPs, the antimicrobial activities of doped-IONPs are also linked to their surface charge, size, and shape. Doping metals on nanoparticles can alter the size and magnetic properties by reducing the energy band gap and combining electronic charges with spins. Furthermore, smaller metal-doped nanoparticles tend to exhibit enhanced antimicrobial activity due to their higher surface-to-volume ratio, facilitating greater interaction with bacterial cells. Moreover, metal doping can also lead to increased charge density in magnetic nanoparticles and thereby elevate reactive oxygen species (ROS) generation. These ROS play a vital role to disrupt bacterial cell membrane, proteins, or nucleic acids. In this review, we compared the antimicrobial activities of different doped-IONPs, elucidated their mechanism(s), and put forth opinions for improved biocompatibility.

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Section: Doped-iron Oxide Nanoparticles (Doped-ionps)mentioning

confidence: 98%

Section: Doped-iron Oxide Nanoparticles (Doped-ionps)mentioning

confidence: 99%

Section: Doped-iron Oxide Nanoparticles (Doped-ionps)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Promise of Metal-Doped Iron Oxide Nanoparticles as Antimicrobial Agent

Tasnim,

Ferdous,

Rumon

et al. 2023

ACS Omega

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“…The cationic ligands of gold NPs have also been shown to contribute to their antimicrobial activity. This effect has been attributed to the strong ionic interaction with bacteria, which shows that positively charged ligand molecules increase the membrane permeability of bacteria: such as gold magnetite NPs and functional gold AuO/Au + used for possible inactivation of synthesized multidrug-resistant bacteria [68] Entry through endoytosis increases the bactericidal properties of nanoparticles ( Figure 2).…”

Section: Pseudomonasmentioning

confidence: 99%

Untitled

Ghandali

Mirnurollahi²,

Safarkar

2021

Asian J. Nanosci. Mater.

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The purpose of this research study was to assess the use of nanoparticles in combat pathogenic microorganisms and also to investigate the synergistic effect of nanoparticles with antibiotics in eliminating these factors. In this work, the influence of different nanoparticles on microorganisms was evaluated in 89 studies. It was found that nanoparticles can be used against microorganisms, either independently or by their synergistic effect with antibiotics. The study found that metal nanoparticles have a more antimicrobial effect, among metal nanoparticles, silver nanoparticles exert the most specific among all microorganisms. Meanwhile, metal nanoparticles can be a good alternative to the use of antibiotics and inhibitors of pathogens.

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