Ultra-Marathon-Induced Increase in Serum Levels of Vitamin D Metabolites: A Double-Blind Randomized Controlled Trial

Mieszkowski, Jan; Stankiewicz, Błażej; Kochanowicz, Andrzej; Niespodziński, Bartłomiej; Kowalik, Tomasz; Żmijewski, Michał A.; Kowalski, Konrad; Rola, Rafał; Bieńkowski, Tomasz; Antosiewicz, Jędrzej

doi:10.3390/nu12123629

Cited by 23 publications

(32 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to some reports, a portion of vitamin D is liberated into the blood during exercise [ 12 ]. Here, accordingly to our previous study [ 9 ], we observed that the levels of 25(OH)D, a vitamin D status marker, significantly increased after the ultramarathon, more so in the supplemented group than in the control group. Hence, elevated vitamin D levels play a key role in the modulation of the inflammatory response in terms of serum marker levels.…”

Section: Discussionsupporting

confidence: 89%

“…This study is a continuation of previous investigation [ 9 ] aimed to assess the impact of single high dose of vitamin D on vitamin D metabolites in ultramarathon runners and is a part of the project: Vitamin D as a Factor Modifying Adaptation to Exercise.…”

Section: Methodsmentioning

confidence: 98%

“…This constitutes a good premise for the application of vitamin D supplementation in endurance runners to decrease the elevated inflammatory response; however, studies involving human subjects assessing the anti-inflammatory effects of vitamin D on inflammation induced by exercise are scarce. It was previously shown that single high dose of vitamin D can upregulate the vitamin D metabolites’ status in ultramarathon runners [ 9 ]. Accordingly, in the current study, we evaluated the impact of a single high-dose vitamin D supplementation on ultramarathon-induced inflammation.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Single High-Dose Vitamin D Supplementation as an Approach for Reducing Ultramarathon-Induced Inflammation: A Double-Blind Randomized Controlled Trial

et al. 2021

Self Cite

View full text Add to dashboard Cite

Purpose: A growing number of studies indicate the importance of vitamin D supplementation for sports performance. However, the effects of a single high-dose vitamin D supplementation on ultramarathon-induced inflammation have not been investigated. We here analyzed the effect of a single high-dose vitamin D supplementation on the inflammatory marker levels in ultramarathon runners after an ultramarathon run (maximal run 240 km). Methods: In the study, 35 runners (amateurs) were assigned into two groups: single high-dose vitamin D supplementation group, administered vitamin D (150,000 IU) in vegetable oil 24 h before the start of the run (n = 16); and placebo group (n = 19). Blood was collected for analysis 24 h before, immediately after, and 24 h after the run. Results: Serum 25(OH)D levels were significantly increased after the ultramarathon in both groups. The increase was greater in the vitamin D group than in the control group. Based on post-hoc and other analyses, the increase in interleukin 6 and 10, and resistin levels immediately after the run was significantly higher in runners in the control group than that in those in the supplementation group. Leptin, oncostatin M, and metalloproteinase tissue inhibitor levels were significantly decreased in both groups after the run, regardless of the supplementation. Conclusions: Ultramarathon significantly increases the serum 25(OH)D levels. Attenuation of changes in interleukin levels upon vitamin D supplementation confirmed that vitamin D has anti-inflammatory effect on exercise-induced inflammation.

show abstract

Section: Discussionsupporting

confidence: 89%

Section: Methodsmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Single High-Dose Vitamin D Supplementation as an Approach for Reducing Ultramarathon-Induced Inflammation: A Double-Blind Randomized Controlled Trial

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…Moreover, it has been shown that circulating 1,25(OH)2D3 correlates better with skeletal muscle strength and muscle genes expression than 25(OH)D3 [ 26 ]. Remember that exercise-induced changes in vitamin D metabolism and formation of some metabolites with no classical vitamin D activity like antioxidant or anti-inflammatory can be expected [ 37 ]. Thus, knowing the blood concentration of 1,25(OH)2D3, 24,25(OH)2D3 and 3-epi-25(OH)D3, in addition to 25(OH)D3 in both groups, could help better to explain the effects of vitamin D supplementation on the outcome of the rehabilitation.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Supplementation Improves the Effects of the Rehabilitation Program on Balance and Pressure Distribution in Patients after Anterior Cervical Interbody Fusion-Randomized Control Trial

et al. 2020

Self Cite

View full text Add to dashboard Cite

Study Design: A double-blinded, randomized controlled trial. Background: Surgery is effective in reducing pain intensity in patients with cervical disc disease. However, functional measurements demonstrated that the results have been not satisfactory enough. Thus, rehabilitation programs combined with the supplementation of vitamin D could play an essential role. Methods. The study recruited 30 patients, aged 20 to 70 years, selected for anterior cervical interbody fusion (ACIF). The patients were randomly divided into the placebo (Pl) and vitamin D (3200 IU D3/day) supplemented groups. The functional tests limits of stability (LOS), risk of falls (RFT), postural stability (PST), Romberg test, and foot pressure distribution were performed before supplementation (BS—week 0), five weeks after supplementation (AS—week 5), four weeks after surgery (BSVR—week 9), and 10 weeks after supervising rehabilitation (ASVR—week 19). Results. The concentration of 25(OH)D3 in the serum, after five weeks of supplementation, was significantly increased, while the Pl group maintained the same. The RFT was significantly reduced after five weeks of vitamin D supplementation. Moreover, a further significant decrease was observed following rehabilitation. In the Pl group, no changes in the RFT were observed. The overall postural stability index (OSI), LOS, and the outcomes of the Romberg test significantly improved in both groups; however, the effects on the OSI were more pronounced in the D3 group at the end of the rehabilitation program. Conclusions. Our data suggest that vitamin D supplementation positively affected the rehabilitation program in patients implemented four weeks after ACIF by reducing the risk of falls and improving postural stability.

show abstract

“…In addition, exercise by itself can modify vitamin D metabolism. For example, 30 min of cycling signi cantly increases serum 25(OH)D 3 levels [19], beside endurance exercise has been shown to increase serum concentration of 24,25(OH) 2 D 3 , 3-epi-25(OH)D [28]. Further, the effect of exercise on the osteoblast and osteoclast metabolism, in addition to the direct effect of loading, is also modi ed by myokines, such as IL-6, IGF-1, FGF2, and others [29, [30].…”

Section: Strengths and Limitations Of The Studymentioning

confidence: 99%

Serum levels of bone formation and resorption markers in relation to vitamin D status in professional gymnastics and physically active men during upper and lower body high-intensity exercise

Mieszkowski

Kochanowicz

Piskorska

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

Purpose/Introduction: To compare serum levels of bone turnover markers in athletes and non-athletes, and to evaluate the relationship between serum levels of vitamin D metabolites and exercise-induced changes in biomarker levels. Methods: Sixteen elite male artistic gymnasts (EG; 21.4 ± 0.8 years-old) and 16 physically active men (the control group, PAM; 20.9 ± 1.2 years-old) performed lower and upper body 30-s Wingate anaerobic tests (LBWT and UBWT, respectively). For biomarker analysis, blood samples were collected before, and 5 and 30 min after exercise. Samples for vitamin D levels were collected before exercise. N-terminal propeptide of type I collagen (PINP) was analysed as a marker of bone formation. C-terminal telopeptide of type I collagen (CTX) was analysed as a marker of bone resorption.Results: UBWT fitness readings were better in the EG group than in the PAM group, with no difference in LBWT readings between the groups. UBWT mean power was 8.8% higher in subjects with 25(OH)D3 levels over 22.50 ng/ml and in those with 24,25(OH)2D3 levels over 1.27 ng/ml. Serum CTX levels increased after both tests in the PAM group, with no change in the EG group. PINP levels did not change in either group; however, in PAM subjects with 25(OH)D3 levels above the median, they were higher than those in EG subjects. Conclusion: Vitamin D metabolites affect the anaerobic performance and bone turnover markers at rest and after exercise. Further, adaptation to physical activity modulates the effect of anaerobic exercise on bone metabolism markers.

show abstract

Ultra-Marathon-Induced Increase in Serum Levels of Vitamin D Metabolites: A Double-Blind Randomized Controlled Trial

Cited by 23 publications

References 45 publications

Single High-Dose Vitamin D Supplementation as an Approach for Reducing Ultramarathon-Induced Inflammation: A Double-Blind Randomized Controlled Trial

Single High-Dose Vitamin D Supplementation as an Approach for Reducing Ultramarathon-Induced Inflammation: A Double-Blind Randomized Controlled Trial

Vitamin D Supplementation Improves the Effects of the Rehabilitation Program on Balance and Pressure Distribution in Patients after Anterior Cervical Interbody Fusion-Randomized Control Trial

Serum levels of bone formation and resorption markers in relation to vitamin D status in professional gymnastics and physically active men during upper and lower body high-intensity exercise

Contact Info

Product

Resources

About