Ultra-low noise PEDOT:PSS electrodes on bacterial cellulose: A sensor to access bioelectrical signals in non-electrogenic cells

Inácio, Pedro M. C.; Medeiros, Maria C. R.; Carvalho, Tiago; Félix, Rute C.; Mestre, A.; Hubbard, Peter C.; Ferreira, Quirina; Morgado, Jorge; Charas, Ana; Freire, Carmen S. R.; Biscarini, Fabio; Power, Deborah M.; Gomes, Henrique L.

doi:10.1016/j.orgel.2020.105882

Cited by 18 publications

(24 citation statements)

References 63 publications

(76 reference statements)

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“…Cellulose is considered the most abundant biopolymer on the planet, being a constituent of most green plants and algae, and naturally secreted in its pure form by some strains of non-pathogenic bacteria (e.g., Komagataeibacter ) [ 66 , 110 ]. This polysaccharide is an eminent feedstock for materials development and can be employed in its native state [ 63 , 64 ] as cellulose derivatives, or in the form of nanofibrils (CNFs) reference [ 85 , 86 , 88 , 89 , 98 , 100 , 101 , 111 ], nanorods (CNCs) [ 69 ], or three-dimensional hydrogel pellicles (BNC) [ 77 , 78 , 79 , 81 , 92 , 93 , 94 , 95 , 104 , 105 , 106 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 ] to manufacture a wide range of materials, as shown in Table 1 . Therefore, the vast majority of the works of our research group entails cellulose nanoforms, i.e., cellulose with at least one dimension in the nanoscale, for the development of nanocomposites [ 98 , ...…”

Section: Natural Polymers-based Materials At the Biopol4fun Research Groupmentioning

confidence: 99%

“…For example, the formulation of biopolymeric chitosan coatings loaded with corrosion inhibitors [ 73 , 102 , 103 ] was adopted for the protection of metallic substrates in corrosive environments. In a different approach, flexible electroconductive substrates with potential application in electronic devices, energy storage, or sensors were devised through the inclusion of copper nanowires [ 111 ] or organic conductive polymer solutions (e.g., poly(3,4-ethylenedioxythiophene): polystyrene sulfonate (PEDOT:PSS) [ 125 ]) in nanocellulosic substrates. The functionalization of biopolymers can also be exploited to impart luminescence or (bio)imaging functions to the ensuing materials; for instance, the blend of chitosan and pullulan films with lanthanopolyoxometalates [ 71 ], the chemical grafting of corrole macrocycles in a chitosan matrix [ 72 ], and the adsorption of a chitosan-derivative containing fluorescein isothiocyanate [ 69 ] on the surface of CNCs.…”

Section: Applications Of Natural Polymers-based Materialsmentioning

confidence: 99%

“…Similarly, lysozyme nanofibrils can provide mechanical reinforcement of polymeric matrices and impart antimicrobial properties that are desirable in active packaging and biomedical applications [ 108 ]. As a result, the proper design of functional biobased polymeric materials increases their application in high-tech fields, including active and intelligent food packaging [ 75 , 89 , 123 ], smart coatings [ 73 , 101 ], drug delivery [ 76 , 78 , 105 ], imaging [ 69 ], water remediation [ 85 , 92 ], sensors [ 111 , 125 ], and fuel cells [ 81 , 95 , 115 ].…”

Section: Perspectives and Conclusionmentioning

confidence: 99%

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Natural Polymers-Based Materials: A Contribution to a Greener Future

et al. 2021

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Natural polymers have emerged as promising candidates for the sustainable development of materials in areas ranging from food packaging and biomedicine to energy storage and electronics. In tandem, there is a growing interest in the design of advanced materials devised from naturally abundant and renewable feedstocks, in alignment with the principles of Green Chemistry and the 2030 Agenda for Sustainable Development. This review aims to highlight some examples of the research efforts conducted at the Research Team BioPol4fun, Innovation in BioPolymer-based Functional Materials and Bioactive Compounds, from the Portuguese Associate Laboratory CICECO–Aveiro Institute of Materials at the University of Aveiro, regarding the exploitation of natural polymers (and derivatives thereof) for the development of distinct sustainable biobased materials. In particular, focus will be given to the use of polysaccharides (cellulose, chitosan, pullulan, hyaluronic acid, fucoidan, alginate, and agar) and proteins (lysozyme and gelatin) for the assembly of composites, coatings, films, membranes, patches, nanosystems, and microneedles using environmentally friendly strategies, and to address their main domains of application.

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Section: Natural Polymers-based Materials At the Biopol4fun Research Groupmentioning

confidence: 99%

Section: Applications Of Natural Polymers-based Materialsmentioning

confidence: 99%

Section: Perspectives and Conclusionmentioning

confidence: 99%

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Natural Polymers-Based Materials: A Contribution to a Greener Future

et al. 2021

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“…Therefore, the use of the mixed ionic-electronic of these doped conjugated polymers systems, rather than metals, allows the creation of an interface with an ion “transduction” between external electronic devices/systems and the biological tissues, where electrical signaling occurs via ionic conduction. As an example, the work of Inácio et al ( 2020 ) evidences improved electrical interfacing of neural probes with PEDOT:PSS, which allows the recording of cellular electrical signals with higher signal-to-noise ratio than metals.…”

Section: Introductionmentioning

confidence: 99%

Effect of Electrical Stimulation Conditions on Neural Stem Cells Differentiation on Cross-Linked PEDOT:PSS Films

Sordini

Garrudo

Rodrigues

et al. 2021

Front. Bioeng. Biotechnol.

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The ability to culture and differentiate neural stem cells (NSCs) to generate functional neural populations is attracting increasing attention due to its potential to enable cell-therapies to treat neurodegenerative diseases. Recent studies have shown that electrical stimulation improves neuronal differentiation of stem cells populations, highlighting the importance of the development of electroconductive biocompatible materials for NSC culture and differentiation for tissue engineering and regenerative medicine. Here, we report the use of the conjugated polymer poly(3,4-ethylenedioxythiophene) doped with polystyrene sulfonate (PEDOT:PSS CLEVIOS P AI 4083) for the manufacture of conductive substrates. Two different protocols, using different cross-linkers (3-glycidyloxypropyl)trimethoxysilane (GOPS) and divinyl sulfone (DVS) were tested to enhance their stability in aqueous environments. Both cross-linking treatments influence PEDOT:PSS properties, namely conductivity and contact angle. However, only GOPS-cross-linked films demonstrated to maintain conductivity and thickness during their incubation in water for 15 days. GOPS-cross-linked films were used to culture ReNcell-VM under different electrical stimulation conditions (AC, DC, and pulsed DC electrical fields). The polymeric substrate exhibits adequate physicochemical properties to promote cell adhesion and growth, as assessed by Alamar Blue® assay, both with and without the application of electric fields. NSCs differentiation was studied by immunofluorescence and quantitative real-time polymerase chain reaction. This study demonstrates that the pulsed DC stimulation (1 V/cm for 12 days), is the most efficient at enhancing the differentiation of NSCs into neurons.

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“…It appears that the measurement itself, involving an ac probing voltage of 0.01 V, affects the interface. This is an unexpected result in view of the large number of reported studies of the PEDOT:PSS/solution interface 18 , 19 .…”

Section: Resultsmentioning

confidence: 84%

Modulation of the electrical double layer in metals and conducting polymers

Morgado

2022

Sci Rep

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The electrical double layer (EDL) formed at the interface between various materials and an electrolyte has been studied for a long time. In particular, the EDL formed at metal/electrolyte interfaces is central in electrochemistry, with a plethora of applications ranging from corrosion to batteries to sensors. The discovery of highly conductive conjugated polymers has opened a new area of electronics, involving solution-based or solution-interfaced devices, and in particular in bioelectronics, namely for use in deep-brain stimulation electrodes and devices to measure and condition cells activity, as these materials offer new opportunities to interface cells and living tissues. Here, it is shown that the potential associated to the double layer formed at the interface between either metals or conducting polymers and electrolytes is modified by the application of an electric field along the conductive substrate. The EDL acts as a transducer of the electric field applied to the conductive substrate. This observation has profound implications in the modelling and operation of devices relying on interfaces between conductive materials (metals and conjugated polymers) and electrolytes, which encompasses various application fields ranging from medicine to electronics.

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Ultra-low noise PEDOT:PSS electrodes on bacterial cellulose: A sensor to access bioelectrical signals in non-electrogenic cells

Cited by 18 publications

References 63 publications

Natural Polymers-Based Materials: A Contribution to a Greener Future

Natural Polymers-Based Materials: A Contribution to a Greener Future

Effect of Electrical Stimulation Conditions on Neural Stem Cells Differentiation on Cross-Linked PEDOT:PSS Films

Modulation of the electrical double layer in metals and conducting polymers

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