Ultra-low-dose chest computed tomography without anesthesia in the assessment of pediatric pulmonary diseases

Dorneles, Cristina Manera; Pacini, Gabriel Sartori; Zanon, Matheus; Altmayer, Stephan; Watte, Guilherme; Barros, Marcelo Cardoso; Marchiori, Edson; Baldisserotto, Matteo; Hochhegger, Bruno

doi:10.1016/j.jped.2018.07.010

Cited by 8 publications

(2 citation statements)

References 28 publications

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“…Only one case had blurring, moderately compromising the image. Furthermore, 51.2% of this cohort went on to be diagnosed with CF [135]. More prospective studies to further assess surveillance with ULDCT or LDCT without anaesthesia in the CF paediatric population would be of value, but the evidence to date is encouraging.…”

Section: Discussionmentioning

confidence: 97%

Paediatric Thoracic Imaging in Cystic Fibrosis in the Era of Cystic Fibrosis Transmembrane Conductance Regulator Modulation

O’Regan,

Stevens,

Logan

et al. 2024

Children

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Cystic fibrosis (CF) is one of the most common progressive life-shortening genetic conditions worldwide. Ground-breaking translational research has generated therapies that target the primary cystic fibrosis transmembrane conductance regulator (CFTR) defect, known as CFTR modulators. A crucial aspect of paediatric CF disease is the development and progression of irreversible respiratory disease in the absence of clinical symptoms. Accurate thoracic diagnostics have an important role to play in this regard. Chest radiographs are non-specific and insensitive in the context of subtle changes in early CF disease, with computed tomography (CT) providing increased sensitivity. Recent advancements in imaging hardware and software have allowed thoracic CTs to be acquired in paediatric patients at radiation doses approaching that of a chest radiograph. CFTR modulators slow the progression of CF, reduce the frequency of exacerbations and extend life expectancy. In conjunction with advances in CT imaging techniques, low-dose thorax CT will establish a central position in the routine care of children with CF. International guidelines regarding the choice of modality and timing of thoracic imaging in children with CF are lagging behind these rapid technological advances. The continued progress of personalised medicine in the form of CFTR modulators will promote the emergence of personalised radiological diagnostics.

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Section: Discussionmentioning

confidence: 97%

Paediatric Thoracic Imaging in Cystic Fibrosis in the Era of Cystic Fibrosis Transmembrane Conductance Regulator Modulation

O’Regan,

Stevens,

Logan

et al. 2024

Children

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show abstract

“…Radiation dose is extremely important in children, as they are more prone to developing radiation-induced carcinogenesis due to longer post-exposure life expectancy and more sensitive organs to the oncogenic effects of radiation. 9 Dorneles et al, 10 in their study showed that a low-dose chest acquisition can be performed with a submillisievert radiation dose, with preservation of image quality, to allow the identification of lung anatomy, common lung diseases and thoracic neoplasms. The present study evaluated only adult patients, requiring further studies in pediatrics.…”

Section: Discussionmentioning

confidence: 99%

Impact of silver beam on radiation dose reduction in chest computed tomography: first impressions

Cirino,

Matsumoto,

Nomura

et al. 2023

JCPCR

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Sedation for Radiological Procedures

Rogers

2021

Pediatric Sedation Outside of the Operating Room

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Ultra-low-dose chest computed tomography without anesthesia in the assessment of pediatric pulmonary diseases

Abstract: Chest ultra-low-dose computed tomography without sedation or anesthesia delivering a sub-millisievert dose can provide image quality to allow identification of common pulmonary anatomy and diseases.

Cited by 8 publications

References 28 publications

Paediatric Thoracic Imaging in Cystic Fibrosis in the Era of Cystic Fibrosis Transmembrane Conductance Regulator Modulation

Paediatric Thoracic Imaging in Cystic Fibrosis in the Era of Cystic Fibrosis Transmembrane Conductance Regulator Modulation

Impact of silver beam on radiation dose reduction in chest computed tomography: first impressions

Sedation for Radiological Procedures

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