“…Determination of individual patient needs remains a challenge, which is only impartially reflected by age. Assessing individual capabilities and needs and matching them to what is needed for a successful procedure is a skill [ 26 ]. Related to this, we predefined a subgroup (1 month–5 years) as priority, assuming that this subgroup commonly requires pharmacological sedation, despite the existence of non-pharmacological tools.…”
Section: Discussionmentioning
confidence: 99%
“…This does not mean that these non-pharmacological tools are not valuable in this age category, as they can either reduce or even replace drug exposure, with the promise of improving self-esteem and self-control in children. Procedure-specific tools, include MRI mockup scanners, video or virtual reality systems, ear protection to distract and reduce stress in patients and the use of a vacuum mattress, among others [ 2 , 3 , 4 , 26 ].…”
There is an increasing need for effective anxiety and pain reduction during medical imaging procedures in children, addressed by non-pharmacological or pharmacological approaches. Dexmedetomidine is a fairly recently marketed, selective α2-adrenergic agonist that can be administered intranasally. To develop an evidence-guided clinical protocol, we investigated the (side) effects, preconditions and safety aspects following intranasal dexmedetomidine administration in children (1 month–5 years) for procedural sedation during medical imaging. To this end, a systematic search (PubMed, Embase and CINAHL (12/2021)) was performed to identify studies on intranasal dexmedetomidine for procedural sedation for medical imaging (computer tomography and magnetic resonance imaging). Following screening and quality assessment, eight studies were retained. Nasal nebulization was considered the best administration method, dosing varied between 2 and 4 µg/kg (age-dependent) 30–45 min prior to imaging and contraindications or restrictions with respect to oral intake were somewhat consistent across studies. Valid sedation scores and monitoring of vital signs were routinely used to assess sedation and the need for rescue dosing (different approaches), whereas discharge was generally based on Aldrete score (score ≥ 9). Heart rate, blood pressure and saturation were routinely monitored, with commonly observed bradycardia or hypotension (decrease by 20%). Based on these findings, a roadmap for evidence-guided clinical protocol was generated.
“…Determination of individual patient needs remains a challenge, which is only impartially reflected by age. Assessing individual capabilities and needs and matching them to what is needed for a successful procedure is a skill [ 26 ]. Related to this, we predefined a subgroup (1 month–5 years) as priority, assuming that this subgroup commonly requires pharmacological sedation, despite the existence of non-pharmacological tools.…”
Section: Discussionmentioning
confidence: 99%
“…This does not mean that these non-pharmacological tools are not valuable in this age category, as they can either reduce or even replace drug exposure, with the promise of improving self-esteem and self-control in children. Procedure-specific tools, include MRI mockup scanners, video or virtual reality systems, ear protection to distract and reduce stress in patients and the use of a vacuum mattress, among others [ 2 , 3 , 4 , 26 ].…”
There is an increasing need for effective anxiety and pain reduction during medical imaging procedures in children, addressed by non-pharmacological or pharmacological approaches. Dexmedetomidine is a fairly recently marketed, selective α2-adrenergic agonist that can be administered intranasally. To develop an evidence-guided clinical protocol, we investigated the (side) effects, preconditions and safety aspects following intranasal dexmedetomidine administration in children (1 month–5 years) for procedural sedation during medical imaging. To this end, a systematic search (PubMed, Embase and CINAHL (12/2021)) was performed to identify studies on intranasal dexmedetomidine for procedural sedation for medical imaging (computer tomography and magnetic resonance imaging). Following screening and quality assessment, eight studies were retained. Nasal nebulization was considered the best administration method, dosing varied between 2 and 4 µg/kg (age-dependent) 30–45 min prior to imaging and contraindications or restrictions with respect to oral intake were somewhat consistent across studies. Valid sedation scores and monitoring of vital signs were routinely used to assess sedation and the need for rescue dosing (different approaches), whereas discharge was generally based on Aldrete score (score ≥ 9). Heart rate, blood pressure and saturation were routinely monitored, with commonly observed bradycardia or hypotension (decrease by 20%). Based on these findings, a roadmap for evidence-guided clinical protocol was generated.
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