Ultra-Jet as a Tool for Dispersing Nanosuspensions

Galinovskiy, A. L.; Htet, Kyaw Myo; Provatorov, A. S.

doi:10.1134/s1995421220020070

Cited by 4 publications

(6 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In general, spray drying proves to be a more cost-effective and practical choice compared to lyophilization. 24 , 30 …”

Section: Factors Affecting the Stability And Efficacy Of Nanosuspensionmentioning

confidence: 99%

“…Distinct physiological solutions must be employed to determine these two crucial parameters. 30 , 35 Saturation solubility and dissolution rate assessments are valuable for predicting the in vitro behavior of the composition. The reduction in particle size leads to an increase in dissolution rate, resulting in elevated dissolution pressure.…”

Section: Parameters Evaluated Reflecting Characteristics Of Nanosuspe...mentioning

confidence: 99%

“…The method for manufacturing nanocrystals for oral, intravenous, or cutaneous use remains consistent, with the only difference lying in the choice of stabilizers. 27 , 30 , 43 …”

Section: Topical Applications Of Nanosuspensionsmentioning

confidence: 99%

“…In general, spray drying proves to be a more cost-effective and practical choice compared to lyophilization. 24,30 Parameters Evaluated Reflecting Characteristics of Nanosuspension Color, Odor, and Taste discrepancies, particularly in the case of active ingredients. Changes in taste, odor, and color may also serve as indicators of chemical instability.…”

Section: Other Additivesmentioning

confidence: 99%

“…5-Interaction with Skin Appendages: Nanoparticles may interact with hair follicles, sweat glands, or other skin appendages, facilitating localized drug delivery. 30 , 31 As illustrated in Figure 1 . Nanosuspensions have found diverse applications in topical formulations, offering advantages such as improved bioavailability and enhanced drug penetration.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Nanosuspension-Based Drug Delivery Systems for Topical Applications

Aldeeb,

Wilar,

Suhandi

et al. 2024

IJN

View full text Add to dashboard Cite

Nanosuspensions have garnered recent attention as a promising strategy for mitigating the bioavailability challenges of hydrophobic drugs, particularly those characterized by poor solubility in both aqueous and organic environments. Addressing solubility issues associated with poorly water-soluble drugs has largely resolved the need to enhance drug absorption and bioavailability. As mucosal formulations and topical administration progress in the future, nanosuspension drug delivery, straightforward formulation techniques, and versatile applications will continue to be subjects of interest. Nanosuspensions have undergone extensive scrutiny in preparation for topical applications, encompassing ocular, pulmonary, and dermal usage. Among the numerous methods aimed at improving cutaneous application, nanocrystals represent a relatively recent yet profoundly intriguing approach. Despite the increasing availability of various nanosuspension products, primarily designed for oral administration, only a limited number of studies have explored skin permeability and drug accumulation in the context of nanosuspensions. Nevertheless, the scant published research unequivocally underscores the potential of this approach for enhancing cutaneous bioavailability, particularly for active ingredients with low to medium solubility. Nanocrystals exhibit increased skin adhesiveness in addition to heightened saturation solubility and dissolution rate, thereby augmenting cutaneous distribution. The article provides a comprehensive overview of nanosuspensions for topical application. The methodology employed is robust, with a well-defined experimental design; however, the limited sample size raises concerns about the generalizability of the findings. While the results demonstrate promising outcomes in terms of enhanced drug delivery, the discussion falls short of addressing certain limitations. Additionally, the references largely focus on recent studies, but a more diverse inclusion of historical perspectives could offer a more holistic view of the subject.

show abstract

“…In general, spray drying proves to be a more cost-effective and practical choice compared to lyophilization. 24 , 30 …”

Section: Factors Affecting the Stability And Efficacy Of Nanosuspensionmentioning

confidence: 99%

Section: Parameters Evaluated Reflecting Characteristics Of Nanosuspe...mentioning

confidence: 99%

“…The method for manufacturing nanocrystals for oral, intravenous, or cutaneous use remains consistent, with the only difference lying in the choice of stabilizers. 27 , 30 , 43 …”

Section: Topical Applications Of Nanosuspensionsmentioning

confidence: 99%

Section: Other Additivesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Nanosuspension-Based Drug Delivery Systems for Topical Applications

Aldeeb,

Wilar,

Suhandi

et al. 2024

IJN

View full text Add to dashboard Cite

show abstract

Study of the Destruction of Carbon Composite Panel using High-Speed Jet of Liquid

Abashin

Galinovskiy

Htet

et al. 2021

IOP Conf. Ser.: Mater. Sci. Eng.

View full text Add to dashboard Cite

The article discusses the task of assessing the damage of carbon fibre plastics arising from the destructive effect of radiation using the diagnostic capabilities of ultra-jet technology. A technique is proposed for determining the thickness of a carbon fibre package that can protect an imaginary interior from the negative effects of radiation waves. As informative diagnostic parameters in the method, the geometrical dimensions of the cavern created on the surface of the sample following exposure to a high-speed jet of liquid (water) are used. Based on the results of the experiments, it was found that a decrease in the depth value indicates a decrease in the penetrating effect of radiation and the destruction of the binder in the structure of the composite material.

show abstract