Ultra-high performance liquid chromatography–atmospheric pressure chemical ionization–tandem mass spectrometry for the analysis of benzimidazole compounds in milk samples

Evolution and applications of the QuEChERS method

“…As a consequence, pharmaceutical-compound analysis is also an active analytical area, in which fast, feasible analytical methods are required, especially in food control and safety. In this sense, the application of the QuEChERS method was demonstrated to be successful (see Table 2 for some examples), for the separate determination of certain families of drugs {e.g., sulfonamides [54], quinolones [55], anthelmintics [19,56,[57][58][59], or benzimidazoles [60]} and to carry out multi-residue analysis [61][62][63][64][65].…”

“…As usual, the separation technique most widely applied for pharmaceutical compounds analysis in combination with QuEChERS is LC, both HPLC [54,61,66] and UHPLC [56][57][58][59][60]63,64]. Even capillary LC [55] or GC (less common) [65] have been selected.…”

Simultaneous determination of nitroimidazoles, benzimidazoles, and chloramphenicol components in bovine milk by ultra-high performance liquid chromatography–tandem mass spectrometry

“…Similarly, chloramphenicol (CAP) has been banned for use in food-producing animals due to the side effect of inducing aplastic anemia (Pfenning et al, 2000). Although analytical methods have been already reported for BENs (De Ruyck, Daeseleire, De Ridder, & Van Renterghem, 2002;Hou et al, 2014;Martínez-Villalba, Moyano, & Galceran, 2013), NIIMs (Tölgyesi et al, 2012), and CAP components (Chen, Wu, & Yang, 2011;Samanidou, Galanopoulos, Kabir, & Furton, 2015) separately, few methods have been described for simultaneous determination of these drugs in animal matrices.…”

Study on the interaction between three benzimidazole anthelmintics and eosin Y by high performance liquid chromatography associating with resonance light scattering and its application

“…Therefore, a new method is researched and developed for the determination of MBZ, ABZ, and FBZ, which is of great importance in physiology and clinical applications. Some methods have been reported for the analysis of MBZ, ABZ, and FBZ, for instance, liquid chromatography (LC) [6][7][8], high performance liquid chromatography (HPLC) [4,9], liquid chromatography-mass spectrometry (LC-MS) [10], capillary electrophoresis-mass spectrometry (CE-MS) [11], UHPLC-MS [12,13], and so on. Although some methods detect low concentration, some inherent issues cannot be avoided effectively, such as complicated pretreatment and operation, expensive apparatus, and complex probe preparation.…”