Ulcerative sarcoidosis. Case report and review of the literature

Albertini, John G.; Tyler, William; Miller, O. Fred

doi:10.1001/archderm.133.2.215

Cited by 44 publications

(54 citation statements)

References 36 publications

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“…Ulcerative sarcoidosis is more common in black-than white-skinned individuals. 48 In our opinion, all these cutaneous lesions can be found in all skin phototypes and ethnic background; however, cutaneous sarcoidosis is clearly more frequent and more severe in patients of African descent. Scar sarcoidosis is also a well-described phenomenon.…”

mentioning

confidence: 73%

Multisystemic diseases and ethnicity: a focus on lupus erythematosus, systemic sclerosis, sarcoidosis and Behçet disease

Petit

Dadzie

2013

Br J Dermatol

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mentioning

confidence: 73%

Multisystemic diseases and ethnicity: a focus on lupus erythematosus, systemic sclerosis, sarcoidosis and Behçet disease

Petit

Dadzie

2013

Br J Dermatol

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“…In the pretibial aspects of the legs, atrophic sclerodermatous plaques with depressed centers assume a necrobiosis lipoidica-like appearance and ulcerate, presumably because of trauma. 65 In one retrospective series, 4.8% of 147 skin sarcoidosis cases had atrophic-ulcerative necrobiosis lipoidica-like plaques. 66 All patients were African American.…”

Section: Papular Sarcoidosismentioning

confidence: 99%

Sarcoidosis

Sanchez

Haimovic

Prystowsky

2015

Dermatologic Clinics

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Sarcoidosis is a disease characterized by noncaseating granulomatous infiltration of 1 or more organs. In North America, after the lungs and thoracic lymph nodes, the skin is the next most commonly involved organ. Data from multiple studies indicate a coaction between genetic and environmental factors in immunologically susceptible hosts. The disease's many clinical manifestations and course vary greatly and are influenced by race, ethnicity, and gender. In the skin, the lesions of sarcoidosis are classified as specific when noncaseating granulomas are present, and nonspecific when there is an inflammatory reaction pattern devoid of granulomas.

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“…In a review of 35 well-documented cases in the English-language literature, Albertini et al [5]found a female predominance with a male-to-female rate of 1:2. In 85% of the patients, the cutaneous lesions were the presenting complaint; in one third of the patients, ulcerations developed in lesions of another morphologic form.…”

Section: Discussionmentioning

confidence: 99%

“…In many cases an extracutaneous manifestation can be found which is one of the reasons for the use of systemic corticosteroids alone or in combination with an antimalarial drug for treatment [5]. Local measures alone often fail.…”

Section: Introductionmentioning

confidence: 99%

Ulcerative Sarcoidosis Successfully Treated with Apligraf

2001

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The case of a 73-year-old female patient is reported with a 25-year-long history of widespread cutaneous sarcoidosis without any known extracutaneous manifestations. The skin manifestations started with erythematous and plaque-like lesions that had ulcerated on the legs for the last half-year. A relevant venous insufficiency or other etiology of the ulcers could not be found. Histology from lesions of the trunk and from the surroundings of the ulcers revealed the typical noncaseating granulomas. A systemic involvement could not be observed; leukopenia and a slightly elevated angiotensin-converting enzyme level in the serum were found. Topical steroids did not prove successful on the ulcers. Apligraf, a bilayered skin equivalent, was transplanted twice on the ulcers leading to complete closure within 3 months. A therapy with systemic steroids could thus be avoided.

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Ulcerative sarcoidosis. Case report and review of the literature

Cited by 44 publications

References 36 publications

Multisystemic diseases and ethnicity: a focus on lupus erythematosus, systemic sclerosis, sarcoidosis and Behçet disease

Multisystemic diseases and ethnicity: a focus on lupus erythematosus, systemic sclerosis, sarcoidosis and Behçet disease

Sarcoidosis

Ulcerative Sarcoidosis Successfully Treated with Apligraf

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