Multisystemic diseases and ethnicity: a focus on lupus erythematosus, systemic sclerosis, sarcoidosis and Behçet disease

Petit, Antoine; Dadzie, Ophelia E.

doi:10.1111/bjd.12533

Cited by 12 publications

(10 citation statements)

References 52 publications

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“…These features that had been observed in previous reports, 7,[29][30][31] were perhaps less easily recognized in this group. 32 A negative association with renal involvement was observed in the European patients, when compared with the other ethnic groups, a result consistent with previous reports. 6,29,[33][34][35] In a systematic review of SLE in Asia, higher rates of renal involvement were described in Asian patients (21-65% at diagnosis and 40-82% at follow-up), when compared with white patients.…”

Section: Discussionsupporting

confidence: 91%

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A study of the influence of ethnicity on serology and clinical features in lupus

Morais

Isenberg

2016

Lupus

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Section: Discussionsupporting

confidence: 91%

“…Skin lesions in SLE are frequent (about 75% of patients) and often polymorphic (25,26). In the present study skin lesions (namely rash and photosensitivity) were less frequent in the Afro-Caribbean group features that have been observed in previous reports (7,(27)(28)(29) perhaps being less easily recognized in this group (30).…”

Section: Discussionsupporting

confidence: 76%

A study of the influence of ethnicity on serology and clinical features in lupus

Morais

Isenberg

2016

Lupus

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“…It has an uneven worldwide distribution with high prevalence rate in European countries such as Scandinavia, where the annual incidence is the highest in the world (64/100 000 people) . Asian people, such as the Chinese or Japanese, are less prone to this disease . There is a female predominance in sarcoidosis and in both sexes the peak incidence occurs in people aged 25–45 years …”

Section: Introductionmentioning

confidence: 99%

Comorbid autoimmune diseases in patients with sarcoidosis: A nationwide case–control study in Taiwan

Chung

et al. 2016

The Journal of Dermatology

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The association between sarcoidosis and autoimmune comorbidities has been reported, however, it has seldom been confirmed by a large nationwide study. Our study aimed to clarify the association between sarcoidosis and autoimmune comorbidities in the Taiwanese. A total of 1237 patients with sarcoidosis and 4948 age- and sex-matched control subjects were selected from the National Health Insurance Research Database of Taiwan from 1997 to 2010. Multiple logistic regressions were performed to calculate the odds of comorbidities between the two groups. The prevalence of sarcoidosis was 2.17/100 000 individuals in Taiwan. Sarcoidosis patients tended to run a higher risk of autoimmune comorbidities than the control group (17.6% vs 9.4%, P < 0.05). Autoimmune thyroid disease (adjusted odd ratio [aOR], 1.32; 95% confidence interval [CI], 1.05-1.64), Sjögren's syndrome (aOR, 11.6; 95% CI, 4.36-31.0) and ankylosing spondylitis (aOR, 3.80; 95% CI, 2.42-5.97) were significantly associated with sarcoidosis. The sex-stratified analyses were carried out to demonstrate a significant association of sarcoidosis with ankylosing spondylitis in both sexes, but with autoimmune thyroid disease in male patients and with Sjögren's syndrome female patients, respectively. Besides, the diagnosis of the autoimmune comorbidities strongly associated with sarcoidosis tended to be established after that of sarcoidosis. This study demonstrated that patients with sarcoidosis tended to have autoimmune thyroid disease, Sjögren's syndrome and ankylosing spondylitis, and the diagnosis of sarcoidosis usually preceded that of associated comorbidities. Clinicians should be alert to autoimmune comorbidities in patients with sarcoidosis.

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“…The most frequently affected organs are the lung and mediastinal lymph nodes, followed by the eyes and skin. [ 1 ]…”

Section: Introductionmentioning

confidence: 99%

“…[ 9 , 10 ] The typical apple-jelly hue, suggestive of a granulomatous process, is rarely observed in dark skin. [ 1 ]…”

Section: Introductionmentioning

confidence: 99%

Cutaneous sarcoidosis

Liu

Tsai²,

Lee³

2017

Medicine

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Sarcoidosis is a systemic granulomatous disorder of unknown etiology often involving skin. Studies on cutaneous sarcoidosis and comorbidities are limited. This study is aimed to describe the clinical features of cutaneous sarcoidosis diagnosed in our hospital and to determine the relationships between cutaneous sarcoidosis and comorbidities.This retrospective study evaluates patients with cutaneous sarcoidosis in a tertiary center in Taiwan from 1996 to 2015. The records of 38 patients with cutaneous sarcoidosis were reviewed for clinical characteristics and evaluated by analysis of variance. A 1:4 case-control analysis was conducted with 152 age- and sex-matched controls who underwent biopsy for other benign skin tumors.The male to female ratio was 1:4.4. The average age at diagnosis was 51.7 years. Female patients were on average 13.9 years older than male patients. The correlation of age with gender was statistically significant (P = .037). The most common cutaneous lesions were plaques (47.4%) and confined to the face (71.1%). Of the 38 patients, 26.3% had diabetes mellitus. Age over 40 (P = .014) and female (P = .014) were associated with facial involvement. In the case-control study, a higher percentage of patients with cutaneous sarcoidosis than of control subjects had diabetes mellitus (P = .001), hearing loss (P = .031) and eye diseases (P = .047).The present study demonstrates a striking female predominance and high proportions of facial involvement. Diabetes mellitus, hearing loss, and eye diseases may be associated with Taiwanese patients with cutaneous sarcoidosis.

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Multisystemic diseases and ethnicity: a focus on lupus erythematosus, systemic sclerosis, sarcoidosis and Behçet disease

Cited by 12 publications

References 52 publications

A study of the influence of ethnicity on serology and clinical features in lupus

A study of the influence of ethnicity on serology and clinical features in lupus

Comorbid autoimmune diseases in patients with sarcoidosis: A nationwide case–control study in Taiwan

Cutaneous sarcoidosis

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