Ulcerative and Inflammatory Lesions of the Oral Mucosa

Philipone, Elizabeth; Peters, Scott M.

doi:10.1016/j.coms.2022.10.001

Cited by 7 publications

(2 citation statements)

References 20 publications

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“…During inflammatory processes of various origins, less differentiated cells, down to basal ones (stage I), are found in imprints with oral mucosa. With hyperkeratosis, on the contrary, there are more stage VI cells [24].…”

Section: Results Of the Study And Discussionmentioning

confidence: 94%

Approaches to the Issue of Screening for Diseases of the Oral Mucosa: A Present View

Bilozetskyi,

Radchuk,

Dzetsiukh

2023

Ukr. Dent. Alm.

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Pathological processes in the oral mucosa in the structure of visits to the therapeutic dentistry clinic occupy a significant niche among all initial visits. In this regard, in the treatment of diseases of the oral mucosa, it is important to include in the complex of diagnostic and preventive measures, which would make it possible to diagnose the pathological process at the preclinical stage, and would be characterized by minimally invasiveness, long-term accuracy, ease of use and would help accelerate the recovery of the mucous membrane. and microcirculation, while having minimal side effects on the body as a whole and providing the possibility of dynamic observation. The purpose of the research is to analyze literature sources in order to comprehensively monitor modern approaches to the issue of screening for diseases of the oral mucosa. Materials and methods. Review and analysis of scientific and medical literature based on Scopus, Web of Science, MedLine, PubMed, NCBI databases, the study of which does not exceed 5-7 years, including literature reviews and results of clinical studies. Research results. In a number of nosological units, changes in the oral mucosa are of a specific nature, when the appearance can make a diagnosis and determine treatment tactics. However, in most cases, the diagnosis of diseases manifested in the oral mucosa is complicated, since the clinical picture is nonspecific and is often aggravated by additional unfavorable local factors. The cellular composition from the lesion, reflecting the dynamics of changes in the mucous membrane during its epithelization, is one of the objective tests for assessing the general condition of the body. Therefore, the study of the processes of differentiation of oral mucosa with an in-depth analysis of the cytological features of various anatomical areas in normal conditions and morphological and cytospecific changes in the presence of an inflammatory process in periodontal tissues is a relevant and promising area of research.

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Section: Results Of the Study And Discussionmentioning

confidence: 94%

Approaches to the Issue of Screening for Diseases of the Oral Mucosa: A Present View

Bilozetskyi,

Radchuk,

Dzetsiukh

2023

Ukr. Dent. Alm.

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“…Oral ulcers can also affect the tongue with several possible etiologies. Depending on their characteristics and course, they can be either acute or chronic [ 4 ]. All of these lesions negatively impact the patients’ sociality, physical and psychological health.…”

Section: Introductionmentioning

confidence: 99%

Healing of induced tongue defects using erythropoietin hydrogel (an experimental study on rats)

Ata,

El-Qashty,

Farid

et al. 2024

BMC Oral Health

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Background Tongue is complex muscular organ that may be affected by recurrent or chronic ulcerations and malignances that require effective treatment to enhance healing and tissue regeneration. So, this study aimed to evaluate the efficiency of erythropoietin (EPO) hydrogel as an anti-inflammatory and an inducer of neovascularization during healing of induced rats’ tongue defects. Methods Thirty six rats were divided into three groups; Group I (negative control): tongues were left without ulceration and received no treatment, Group II (positive control): tongue defects were prepared on the tongues’ dorsal surfaces, measuring (5 mm × 2 mm) using a tissue punch rotary drill for standardization, and left untreated, Group III (EPO group): tongue defects were prepared as in group II, then injected circumferentially around wound margins with a single high dose of EPO hydrogel of 5000 U/kg on the day of defect preparation. Animals were euthanized on seventh and fourteenth days after treatment, tongue specimens were collected, and paraffin blocks were prepared and processed for histological assessment by hematoxylin and eosin stain and immunohistochemical evaluation of anti-iNOS and anti-VEGF followed by histomorphometrical analysis and the relevant statistical tests. Results At both time points, the EPO treated group showed significantly enhanced tissue regeneration marked by the histologically better regenerated tissue with well developed, thick walled and well-organized blood vessels and significant reduction in defect depth compared to positive control group. EPO group also showed significant decrease in iNOS and significant increase in VEGF antibodies indicating its anti-inflammatory and neovascularization effects respectively. Conclusion EPO treatment can significantly accelerate regeneration and filling of tongue defects by reducing tissue inflammation and enhancing neovascularization. Therefore, EPO could be a potential therapeutic strategy for accelerating healing of tongue ulcers. However, further investigations are required to optimize the dose and unravel any potential side effects before its clinical application.

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