Ulceration in the rat's forestomach: Its reduction by non-nutritive bulky substances

Mikhail, A.A.; Hirschberg, Joseph

doi:10.1016/0031-9384(72)90110-2

Cited by 21 publications

(7 citation statements)

References 4 publications

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“…This contrasts with the effect of prolonged starvation (at least 96 hours) in adult rats, which causes lesions primarily in the nonsecretory gastric rumen (5,6).…”

Section: Resultsmentioning

confidence: 95%

Age at Maternal Separation and Gastric Erosion Susceptibility in the Rat*

Ackerman¹,

Hofer²,

Weiner³

1975

Psychosomatic Medicine

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The development of susceptibility to immobilization-induced gastric erosions was studied in laboratory rats previously separated from their mothers at 15, 21 or 25 days of age. Early separation (day 15) produced animals whose maximum susceptibility occurred at a much younger age, generated a susceptibility curve over life that was the inverse of the curve for animals separated later and led to severe gastrointestinal hemorrhage as a common and distinguishing complication in younger rats. The pathogenesis of erosion formation in early separated rats may be unique in that, for that group only, the food deprivation component of the immobilization paradigm, when presented alone, also produced erosion of the glandular stomach, with hemorrhage.

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“…This contrasts with the effect of prolonged starvation (at least 96 hours) in adult rats, which causes lesions primarily in the nonsecretory gastric rumen (5,6).…”

Section: Resultsmentioning

confidence: 95%

Age at Maternal Separation and Gastric Erosion Susceptibility in the Rat*

Ackerman¹,

Hofer²,

Weiner³

1975

Psychosomatic Medicine

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“…However, it was also reported that " most of the nylon bristles had been bitten off" (Vincent et al, 1984, p. 266), and that wood targets had chewed " on the order of .5 to 2 g over 6 h " (Guile & Mc-Cutcheon, 1980, p. 481). Since the intake of solid non-nutritive bulk has been shown to protect against ulceration in the stomach (Mikhail & Hirschberg, 1972), the stressreducing effect observed in these studies is due to the opportunity to eat the target objects rather than the opportunity to express the aggression against the target objects. Guile and McCutcheon (1980, p. 482) themselves reported the lack of stress-reducing effect of biting against non-eatable stainless steel targets.…”

Section: Discussionmentioning

confidence: 97%

Some social factors relevant to the stress-reducing effect of fighting in rats

Hamamura

Kobayashi

1986

Jpn. Psychol. Res

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The aim of this experiment was to study some intrinsic factors relevant to the stress-reducing effect of fighting. Two-factorial design was employed: one factor was to concern the nature of reactive feedback that came from each target animal, and another to concern the nature of social contact (visual and/or bodily). The main results were as follows:(i) the animals shocked together and fought with each other tended to show less severe gastric lesions than both of those animals that received the same amount of shock either solitarily or under the condition that they were permitted to attack their target animals exposed to no shock, and (ii) the stressreducing effect of fighting was observed only when animals were allowed to make bodily contact with their target animals. These results indicates that the mere release of aggression is not sufficient to reduce the degree of gastric lesions, but some social elements plays an important role in the stress-reducing effect of fighting.

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“…There are few published data describing the lesions of anorexia or starvation in pigs. In mice and rats, food deprivation results in gastric erosion and ulceration; 1,13,15 however, lesions have developed in the fundus of mice 15 but in the nonsecretory regions of rats. 1,13 In pigs, gastric ulcers associated with feed disruption almost always have developed in the nonsecretory pars esophagea, 4 but the lesions observed in PFTS-CASE pigs were almost exclusively in the fundus.…”

Section: Discussionmentioning

confidence: 99%

“…1,13 In pigs, gastric ulcers associated with feed disruption almost always have developed in the nonsecretory pars esophagea, 4 but the lesions observed in PFTS-CASE pigs were almost exclusively in the fundus. Furthermore, the erosions described in mice and rats have been grossly visible, 1,13,15 but those in PFTS pigs were microscopic and ulceration was not present. Although the attenuation of foveolar cells in PFTS pigs might represent disuse atrophy associated with anorexia, the increased lymphoplasmacytic infiltrate cannot be easily explained by anorexia alone.…”

Section: Discussionmentioning

confidence: 99%

“…In mice and rats, food deprivation results in gastric erosion and ulceration; 1,13,15 however, lesions have developed in the fundus of mice 15 but in the nonsecretory regions of rats. 1,13 In pigs, gastric ulcers associated with feed disruption almost always have developed in the nonsecretory pars esophagea, 4 but the lesions observed in PFTS-CASE pigs were almost exclusively in the fundus. Furthermore, the erosions described in mice and rats have been grossly visible, 1,13,15 but those in PFTS pigs were microscopic and ulceration was not present.…”

Section: Discussionmentioning

confidence: 99%

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Pathological Features and Proposed Diagnostic Criteria of Porcine Periweaning Failure-to-Thrive Syndrome

Huang

Harding

2014

Vet Pathol

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Porcine periweaning failure-to-thrive syndrome (PFTS) is a clinical syndrome characterized by anorexia and progressive debilitation of newly weaned pigs. The objectives of the current case-control study were to describe the histopathologic features of PFTS in North America and test for selected pathogens in case and control pigs on 8 farms allegedly fulfilling the clinical definition of PFTS. Based on observations during farm visits, 5 farms fully met the case definition (PFTS farms), whereas 3 farms only partially fulfilled the definition (NON-PFTS farms). Necropsy and histopathologic examination were performed on case (n ¼ 8 or 9) and control (n ¼ 4) pigs from each farm. Superficial gastritis, which was mainly localized in the fundus and characterized by attenuation of superficial foveolar cells, was significantly more frequent in case pigs from PFTS farms compared with all the other pigs (odds ratio [OR], 16.7). The same was found for thymic atrophy (OR, 30.1) and small intestinal (SI) villous atrophy in the duodenum (OR, 28.7), jejunum (OR, 67.4), and ileum (OR, 56.3). All pigs with PFTS had at least 2 of these 3 lesions: gastritis, thymic atrophy, and SI villous atrophy. PFTS was not associated with any relevant porcine pathogen tested. We propose the diagnosis of PFTS be based on the fulfillment of the clinical case definition, the presence of the above lesions, and exclusion of other common swine diseases and pathogens. However, PFTS can be ruled out if debilitated pigs do not have at least 2 of the above 3 lesions.

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Ulceration in the rat's forestomach: Its reduction by non-nutritive bulky substances

Cited by 21 publications

References 4 publications

Age at Maternal Separation and Gastric Erosion Susceptibility in the Rat*

Age at Maternal Separation and Gastric Erosion Susceptibility in the Rat*

Some social factors relevant to the stress-reducing effect of fighting in rats

Pathological Features and Proposed Diagnostic Criteria of Porcine Periweaning Failure-to-Thrive Syndrome

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