“…Ulceration with extrusion of calcified material sometimes occurs, giant lesions up to 15 cm have been reported , and familial and multiple pilomatricomas have been associated with a variety of syndromes (myotonic dystrophy, familial adenomatous polyposis, Turner syndrome, trisomy 9, Kabuki syndrome, Rubinstein–Taybi syndrome, sarcoidosis, gliomatosis cerebri, xeroderma pigmentosum, and basal cell nevus syndrome) .…”