UK audit of quantitative thyroid uptake imaging

Taylor, Jonathan; Murray, Anthony W.; Hall, D.O.; Barnfield, Mark C.; O’Shaugnessy, Emma R.; Carson, K.J.; Cullis, James; Towey, David; Kenny, Bob

doi:10.1097/mnm.0000000000000681

Cited by 4 publications

(6 citation statements)

References 6 publications

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“…Our survey among nuclear medicine departments at Dutch hospitals, despite moderate response in a fairly small sample size, clearly showed significant differences in technical performance of RAIU test examinations in routine clinical practice, including differences in equipment, isotope, isotope formulation, amount of activity, use of neck phantoms, frequency and duration of reference measurements, distance to collimator head, background measurements and region-of-interest delineation. These results are in line with previous studies from the UK [ 20 ], France [ 21 ] and Germany [ 22 ]. The study from the UK was a national audit of thyroid uptake imaging that showed large variation in software, isotope, dosages, collimators, duration and ROI delineation and concluded that most UK centers do not adhere to all aspects of BNMS guidelines [ 20 ].…”

Section: Discussionsupporting

confidence: 93%

“…These results are in line with previous studies from the UK [ 20 ], France [ 21 ] and Germany [ 22 ]. The study from the UK was a national audit of thyroid uptake imaging that showed large variation in software, isotope, dosages, collimators, duration and ROI delineation and concluded that most UK centers do not adhere to all aspects of BNMS guidelines [ 20 ]. The study from France was a nationwide survey that also showed significant variation in isotope, dosages, time points of measurement post-injection and method of thyroid volumetry (ultrasound, scintigraphy or palpation) [ 21 ].…”

Section: Discussionsupporting

confidence: 93%

“…Recent surveys in UK [ 20 ], France [ 21 ] and Germany [ 22 ] have shown large variation in RAIU measurement techniques in routine clinical practice, including differences in equipment and software, isotope, dosages, collimators, time points, measurement duration and region-of-interest (ROI) delineation, all of which may affect measurement outcome. A potential strategy for further standardization of RAIU measurement is the elimination of the need for (and use of) reference source measurements [ 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

“…As previous surveys on RAIU measurement practices [ 20 – 22 ] did not focus specifically on the reference source measurements, we first conducted a survey among all nuclear medicine departments in Dutch hospitals to identify technical variations in performing RAIU and reference standard measurements. Secondly, we performed a phantom study to evaluate variation in measurement outcomes using different isotope formulations, different activity dosages and different region-of-interest definitions to quantify the potential for reduction in variability.…”

Section: Introductionmentioning

confidence: 99%

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Gamma camera-specific reference standards for radioactive iodine uptake measurements

Mourik,

Derks,

te Beek

et al. 2023

EJNMMI Phys

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Background Current guidelines of the radioiodine uptake (RAIU) test allow the use of different equipment, isotopes, activity and region-of-interest (ROI). We evaluated presence and extent of these differences in clinical practice and evaluated the effect of some of these variations on RAIU outcomes. Also, gamma camera-specific reference standards were calculated and retrospectively compared with measurements obtained during clinical RAIU tests. Materials and methods First, questionnaires were sent to Dutch nuclear medicine departments requesting information about equipment usage, isotope, isotope formulation, activity and measurement techniques. Secondly, a neck phantom containing a range of activities in capsule or water-dissolved formulation was scanned. Counts were measured using automatic ROI, square box ROI or all counts in the image. Thirdly, clinical RAIU data were collected during 2015–2018 using three different gamma cameras. Reference standards for each scanner were calculated using regression analysis between reference activity and measured counts. Uptake measurements using this gamma camera-specific reference standard were compared with original measurements. Results The survey demonstrated significant differences in isotope, isotope formulation, activity, use of neck phantoms, frequency and duration of reference measurements, distance to collimator, use of background measurements and ROI delineation. The phantom study demonstrated higher counts for the water-dissolved formulation than capsules using both automatic and square box ROI. Also, higher counts were found using a square box ROI than an automatic ROI. The retrospective study showed feasibility of RAIU calculations using camera-specific reference standards and good correlation with the original RAIU measurements. Conclusions This study demonstrated considerable technical variation in RAIU measurement in clinical practice. The phantom study demonstrated that these differences could result in differences in count measurements, potentially resulting in different dose calculations for radioactive iodine therapy. Retrospective data suggest that camera-specific reference standards may be used instead of individual reference measurements using separate activity sources, which may thus eliminate some sources of variation.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Gamma camera-specific reference standards for radioactive iodine uptake measurements

Mourik,

Derks,

te Beek

et al. 2023

EJNMMI Phys

View full text Add to dashboard Cite

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“…Geographical location-based reference range for thyroid uptake of 99mTc pertechnetate are rarely found in literature and the normal reference values for thyroid uptake of 99mTc pertechnetate changes significantly from time to time 6,7 . 99mTc for thyroid uptake is now commonly used in several countries but fluctuations in the normal reference values of 99mTc thyroid uptake has been documented at different centers 8 . The normal value for 99mTc uptake recommended globally is 0.3-4.5% 9 .…”

Section: Discussionmentioning

confidence: 99%

Determination of Normal Thyroid Technetium-99m Uptake Value in a Single Centre Pakistani Population

Malik

Hussain

Ashraf

et al. 2021

PAFMJ

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Objective: To determine the normal value of thyroid Technetium-99m uptake value in a single centre Pakistani population. Study Design: Cross-sectional study. Place and Duration of Study: Nuclear Medical Centre, Armed Forces Institute of Pathology, Rawalpindi, from Feb 2019 to Apr 2020. Methodology: A total of 90 patients who presented to Nuclear Medical Centre for parathyroid dual radiopharmaceutical scintigraphy were included in study and selected by non-probability consecutive sampling technique. Thyroid uptake studies were calculated via gamma camera acquisition. Pre injection counts were taken from the Technetium-99m pertechnetate filled syringe, thyroid counts were taken from the anterior thyroid image 20 minutes post injection and to look for any residual radiopharmaceutical counts of the empty syringe were also taken. Results: Out of total of 90 patients, 32 (35.6%) were male while 58 (64.4%) were female with male to female ratio of 1:2. The mean age was 38.4 ± 12.7. Mean Thyroid Stimulating Hormone values were 1.6 ± 0.8 and mean T4 values were 11.9 ± 3.5. The 5th-95th percentile range was 0.4-2.2% and median was 1.2%. The interquartile range was calculated to be 0.9-1.5%. Conclusion: Normal value of thyroid Technetium-99m uptake value in a single centre Pakistani population values varies significantly as compared to global figures i.e. 0.3-4.5% and is different than the one used in our own department i.e. 0.5-2.0%.

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Comparison of plasma clearance of [51Cr]CrEDTA based on three, two and single samples to measure the glomerular filtration rate in patients with solid tumors: a prospective cross-sectional analysis

Gomes,

Coura Filho,

Gil Junior

et al. 2024

Clinics

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UK audit of quantitative thyroid uptake imaging

Abstract: A UK-wide audit showed that thyroid uptake imaging is still a common test in the UK. It was found that most centres do not adhere to all aspects of the BNMS practice guidelines but that quantitative results are reasonably consistent for Tc-based scans.

Cited by 4 publications

References 6 publications

Gamma camera-specific reference standards for radioactive iodine uptake measurements

Gamma camera-specific reference standards for radioactive iodine uptake measurements

Determination of Normal Thyroid Technetium-99m Uptake Value in a Single Centre Pakistani Population

Comparison of plasma clearance of [51Cr]CrEDTA based on three, two and single samples to measure the glomerular filtration rate in patients with solid tumors: a prospective cross-sectional analysis

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