UJI MUTU FISIK GRANUL EKSTRAK ETANOL DAUN KEMANGI (Ocimum americanum L.) DENGAN VARIASI KONSENTRASI EXPLOTAB®

Abstract

Bad breath is usually caused by bacteria and food debris left in the mouth. Development of preparations using herbal ingredients, to overcome the problem of bad breath one of them is with utilization basil leaves (Ocimum americanum L.) which have anti bacterial activity. The method of wet granulation is a single method for use in granulation of large doses of active substances because if using direct induced method will require again the addition of a large number of fillers to make it easier forging, but cause the tablet to be not feasible as it will resulting in an increase in tablet size. The type of research conducted is an experimental study. Object the study was basil leaf extract formulated. This formulation was prepared by wet granulation method with variation Explotab® ss crusher ie 2%, 4%, 6% and 8%. Performed wet granulation on each formulation. Granul evaluated the flow time, mass density test, silent angle and fixed assay test. Based on research result the physical quality of ethanol extract granule of basil leaves (Ocimum americanum L.) with explotab® concentration variation it can be concluded that all the formula fulfill the good quality of granule characteristic, because it meets the requirements of parameters of time flow, rest angle, compressibility and density mass

Formulasi dan Evaluasi Granul Instan Ekstrak Etanol Daun Kenikir (Cosmos caudatus) sebagai Antioksidan

“…Ditimbang granul sebanyak 100 gram dan dimasukan ke dalam corong pada alat granul flow tester, dibuka penutup bawah corong dan dihitung waktu jatuhnya granul menggunakan stopwatch (17).…”

Formulasi Serbuk Instan Ekstrak Pegagan (Centella asiatica) dan Jahe Merah (Zingiber Officinale Roscoe Var. Rubrum)

“…Densitas yang besar akan memiliki berat molekul yang lebih besar sehingga semakin mudah mengalir karena gaya gravitasi semakin besar. Semakin tinggi densitas massa granul menyebabkan waktu alirnya semakin cepat [27]. Berdasarkan hasil uji pengetapan didapatkan bahwa formula 3 mempunyai pengetapan yang paling baik diantara formula 1 dan formula 2 karena mengandung laktosa sebesar 80%.…”

Optimization of Non-Effervescet Floating Tablets Ranitidine HCL Formula Using Durian Seed Matrix (Durio Zibethinus Murr) Fully Gelatinized Modified Using Simplex Lattice Design Method

“…A small density means a small molecular weight, reducing the influence of gravity on the mass because cohesive forces are higher than gravitational forces, preventing granules from flowing freely (Elisabeth, 2018;Ririn & Balfas, 2020). Granules have good flow properties if 100 g of granules have a flow time of ≤ 10 seconds or a flow rate of 10 g/second ( (Soemarie et al, 2017). The flow time testing results range from 9.15 to 9.69 seconds (Table 7).…”