UJI AKTIVITAS ANTIDIABETES EKSTRAK ETANOL KULIT KAYU MANIS (Cinnamomum burmanii Nees ex.Bl.) DIBANDINGKAN DENGAN GLIBENKLAMID PADA MENCIT JANTAN GALUR Swiss Webster DENGAN METODE TOLERANSI GLUKOSA

Hananti, Rina Sari; Hidayat, Saeful; Yanti, Lisma

doi:10.58327/jstfi.v1i1.10

Cited by 4 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Glycoside compounds, which have a benzene ring structure and a sugar group, are very reactive to hydroxyl radicals and thus act as hydroxyl radical scavengers (Studiawan and Santosa 2005). A decrease in blood glucose levels can also be caused by the presence of tannin compounds, which can increase the sensitivity of pancreatic β-cells to insulin release (Hananti, Hidayat, and Yanti 2018). These compounds can neutralize and prevent alloxaninduced free radical damage in normal pancreatic beta cells (Atangwho et al 2008).…”

Section: Discussionmentioning

confidence: 99%

ANTIDIABETIC EFFECT OF ETHANOLIC EXTRACT OF KEDONGDONG PAGAR LEAVES (Lannea coromandelica (Houtt.) Merr.) ON MALE MICE

Safriana,

Kusumastuti,

Andilala

2024

View full text Add to dashboard Cite

Diabetes mellitus is a metabolic condition defined as an increase in blood glucose levels (hyperglycemia) caused by impaired insulin production or insulin action. One of the treatments for diabetes mellitus is the use of medicinal plants because they contain bioactive phytochemicals. Kedongdong pagar leaves (Lannea coromandelica (Houtt.) Merr.) is an empirical medication used to reduce the blood glucose levels in Aceh, Indonesia. The leaves contain flavonoids, which have antioxidant effects that can reduce damage to the pancreatic beta cells. The goal of this study was to examine the antidiabetic impact of an ethanol extract of kedongdong pagar leaves in male mice induced with alloxan to increase blood glucose levels. The test procedure involved splitting 25 mice into five treatment groups, Na-CMC suspension 0.5% w/v, Kedongdong pagar extract with dose 10 mg/kg BW, 20 mg/kg BW, 40 mg/kg BW, and glibenclamide suspension with dose 0.65 mg/kg BW as positive control. The results showed that all ethanolic extracts of Lannea coromandelica had the same potency to lower blood glucose levels in mice, implying that the ethanol extract of Lannea coromandelica leaves had antidiabetic activity due to the presence of antidiabetic compounds such as flavonoids and glycosides. Keywords: Antidiabetic, Diabetic, Kedongdong Pagar Leaves, Lannea coromandelica.

show abstract

Section: Discussionmentioning

confidence: 99%

ANTIDIABETIC EFFECT OF ETHANOLIC EXTRACT OF KEDONGDONG PAGAR LEAVES (Lannea coromandelica (Houtt.) Merr.) ON MALE MICE

Safriana,

Kusumastuti,

Andilala

2024

View full text Add to dashboard Cite

show abstract

“…Diare merupakan suatu gangguan pada saluran pencernaan dimana konsistensi feses berbentuk cair atau setengah cair dan frekuensi defekasinya lebih sering dari keadaan normalnya yang biasanya disebabkan oleh gangguan ketidakseimbangan absorpsi dan sekresi air serta elektrolit di usus [1]. Penyebab utama kematian akibat diare adalah dehidrasi atau kekurangan cairan dan penyebab lainnya yaitu infeksi bakteri septik [2].…”

Section: Pendahuluanunclassified

Uji Efek Antidiare Ekstrak Rimpang Kunyit Hitam (Curcuma caesia Roxb.) terhadap Mencit (Mus musculus)

Safitri,

Sulistiarini,

Jafar

2023

Proc. Mul. Pharm. Conf.

View full text Add to dashboard Cite

Diarrhea is a disease characterized by increased frequency of defecation and decreased stool consistency caused by impaired absorption of air and electrolytes in the intestine. Black turmeric is a plant that has properties as a traditional medicine for types of diseases, one of which is diarrhea. The aim of this study was to determine the antidiarrheal effect of black turmeric rhizome extract and the best dose of reducing defecation frequency and increasing stool consistency in diarrheal mice. This research was carried out using 40 mice that were induced by diarrhea using Ricini oleum. Mice were divided into 8 groups, the normal group without treatment, the positive control was given Loperamide HCl, the negative control was given 1% NaCMC, the test control group was given 5 variations of doses of black turmeric rhizome extract 50 mg/KgBW, 150 mg/KgBW, 250 mg/KgBW, 300 mg/KgBW, and 500 mg/KgBW. The results showed that black turmeric rhizome extract could reduce the frequency of defecation and increase stool consistency with a significant value (p<0.05). Black turmeric rhizome extract at a dose of 250 mg/KgBW is the best dose because it can reduce the frequency of defecation and increase stool consistency better than Loperamide HCl. Keywords: Antidiarrheal, Black turmeric, Oleum ricini Abstrak Diare merupakan penyakit yang ditandai dengan peningkatan frekuensi defekasi dan penurunan konsistensi feses disebabkan oleh gangguan absorpsi air dan elektrolit di dalam usus. Kunyit hitam disebut sebagai tanaman yang memiliki khasiat sebagai obat tradisional untuk berbagai jenis penyakit salah satunya diare. Tujuan penelitian ini adalah untuk mengetahui efek antidiare ekstrak rimpang kunyit hitam dan dosis terbaik dalam memberikan efek penurunan frekuensi defekasi dan peningkatan konsistensi feses pada mencit diare. Penelitian ini dilakukan dengan menggunakan 40 ekor mencit yang diinduksi diare menggunakan oleum ricini 0,75 ml. Mencit dibagi menjadi 8 kelompok yaitu kelompok normal tanpa perlakuan, kontrol positif diberi Loperamide HCl, kontrol negatif diberi NaCMC 1%, kelompok kontrol uji diberi 5 variasi dosis ekstrak rimpang kunyit hitam 50 mg/KgBB, 150 mg/KgBB, 250 mg/KgBB, 300 mg/KgBB, dan 500 mg/KgBB. Hasil penelitian menunjukkan bahwa ekstrak ekstrak rimpang kunyit hitam dapat menurunkan frekuensi defekasi dan meningkatkan konsistensi feses dengan nilai signifikasi (p<0,05). Ekstrak rimpang kunyit hitam dosis 250 mg/KgBB merupakan dosis terbaik karena dapat menurunkan frekuensi defekasi dan meningkatkan konsistensi feses dengan hasil lebih baik dari Loperamide HCl. Kata Kunci: Antidiare, Kunyit hitam, Oleum ricini

show abstract

“…Pada penelitian sebelumnya, ekstrak etanol kulit kayu manis telah diuji dengan metode tes toleransi glukosa. Diketahui bahwa ekstrak dengan dosis 100 mg/kgBB dapat menurunkan kadar glukosa darah sebesar 21,32% (6). Diduga kuat senyawa aktif yang memiliki aktifitas sebagai antidiabetes pada kulit kayu manis adalah Methyl Hydroxy Chalcone Polymer (MHCP) dan Sinamaldehid.…”

Section: Aunclassified

“…Tabel 3. Hasil skrinning fitokimia simplisia dan ekstrak kulit kayu manis Senyawa metabolit sekunder golongan alkaloid, fenolat, tannin, flavonoid, kuinon, saponin, monoterpen dan seskuiterpen diketahui terkandung didalam kulit kayu manis (6)…”

Section: Skrinning Fitokimiaunclassified

Uji Antidiabetes Ekstrak Kulit Kayu Manis (Cinnamomum burmannii (Nees & T.Nees) Blume) dengan Metode Resistensi Insulin pada Mencit Swiss Webster Jantan yang Diinduksi Emulsi Tinggi Lemak

Mawali,

Choesrina,

Mulqie

2023

BCSP

View full text Add to dashboard Cite

Abstrak. Kulit kayu manis (Cinamomun Burmanii (Nees & T.Nees) Blume) secara empiris digunakan masyarakat indonesia untuk mengatasi diabetes mellitus. Diduga kuat senyawa dari kulit kayu manis yang berperan yaitu MHCP dan sinamaldehid. Tujuan dilakukan penelitian ini yaitu untuk mengetahui efektivitas serta dosis ekstrak kulit kayu manis dalam mencegah kenaikan kadar glukosa darah dan meningkatkan sensitivitas jaringan terhadap insulin pada mencit swiss webster jantan dengan metode resistensi insulin.Hewan uji dibagi menjadi 6 kelompok yang terdiri dari kelompok kontrol negatif, kontrol positif, pembanding metformin 65 mg/kgBB, ekstrak etanol kulit kayu manis (EKKM) dosis 50, 100, dan 200 mg/kgBB. Pengujian dilakukan secara preventif dimana induksi dan pengobatan diberikan secara bersamaan. Tiap kelompok diberi induksi Lipofundin® MCT/LCT 20% dan fruktosa kecuali kontrol negatif. Parameter yang diamati yaitu kadar glukosa darah hari ke 0, 7, 14, dan 20 serta nilai KTTI sebagai parameter sensitivitas insulin yang diperoleh dari tes toleransi insulin. Berdasarkan pengujian, diketahui bahwa pada EEKKM dosis 50, 100, dan 200 mg/kgBB memiliki nilai KTTI secara berturut turut yaitu 15,475; 10,858; dan 10,43. Dari pengujian tersebut dapat disimpulkan pada pemberian ketiga dosis EEKKM dapat mencegah kenaikan kadar glukosa darah serta dapat meningkatkan sensitivitas insulin dimana potensi aktivitas antidiabetes terbaik terdapat pada EEKKM dosis 50 mg/kgBB. Abstract. Cinnamon bark (Cinamomun Burmanii (Nees & T.Nees) Blume) has been empirically used by the people of Indonesia to overcome diabetes mellitus. It is strongly suspected that compounds of cinnamon bark which play a role are MHCP and cinnamaldehyde. The purpose of this study was to determine the effectiveness and dose of cinnamon bark extract in preventing an increase in blood glucose levels and increasing tissue sensitivity to insulin in male swiss webster mice with insulin resistance method. Test animals were divided into 6 groups consisting of negative control, positive control, metformin 65 mg/kgBB, and cinnamon bark extract (EEKKM) doses 50, 100, dan 200 mg/kgBB. Testing is carried out preventively where induction and treatment are given simultaneously. Each group was given a 20% Lipofundin® MCT/LCT and fructose except negative control.The parameters observed were blood glucose levels on days 0, 7, 14, and 20 and and KTTI values as insulin sensitivity parameters obtained from insulin tolerance tests. Based on testing, it is known that in EEKKM doses of 50, 100, and 200 mg/kg BB have KTTI values respectively of 15.475; 10,858; and 10.43. From these tests, it can be concluded that the administration of the three doses of EEKKM can prevent increases in blood glucose levels and can improve insulin sensitivity where the best potential antidiabetic activity is found in EEKKM doses of 50 mg/kg BB.

show abstract

UJI AKTIVITAS ANTIDIABETES EKSTRAK ETANOL KULIT KAYU MANIS (Cinnamomum burmanii Nees ex.Bl.) DIBANDINGKAN DENGAN GLIBENKLAMID PADA MENCIT JANTAN GALUR Swiss Webster DENGAN METODE TOLERANSI GLUKOSA

Cited by 4 publications

References 0 publications

ANTIDIABETIC EFFECT OF ETHANOLIC EXTRACT OF KEDONGDONG PAGAR LEAVES (Lannea coromandelica (Houtt.) Merr.) ON MALE MICE

ANTIDIABETIC EFFECT OF ETHANOLIC EXTRACT OF KEDONGDONG PAGAR LEAVES (Lannea coromandelica (Houtt.) Merr.) ON MALE MICE

Uji Efek Antidiare Ekstrak Rimpang Kunyit Hitam (Curcuma caesia Roxb.) terhadap Mencit (Mus musculus)

Uji Antidiabetes Ekstrak Kulit Kayu Manis (Cinnamomum burmannii (Nees & T.Nees) Blume) dengan Metode Resistensi Insulin pada Mencit Swiss Webster Jantan yang Diinduksi Emulsi Tinggi Lemak

Contact Info

Product

Resources

About