Ueber Reduction des Chlorsilbers

Hirschberg, A.

doi:10.1002/ardp.18661770108

Cited by 1 publication

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“…For drug formulations, animal studies are sometimes performed, whereas this is not allowed for cosmetic ingredients and final products in the EU. Furthermore, animal skin is different from human skin regarding morphology and barrier properties . As an alternative, to screen topical formulations on enhancing skin barrier repair, recently we developed the SkinBaR model .…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, animal skin is different from human skin regarding morphology and barrier properties. 20 As an alternative, to screen topical formulations on enhancing skin barrier repair, recently we developed the SkinBaR model. 21 This model is based on ex vivo human skin from which SC was removed.…”

Section: Discussionmentioning

confidence: 99%

“…To develop topical formulations to treat impaired skin barrier, often animal skin or clinical studies are used as no proper ex vivo skin models are available. However, this is far from optimal because animal skin is different from human skin, and in a formulation development phase, only a limited number of formulations can be tested in clinical settings. Therefore, recently an ex vivo human skin barrier repair (SkinBaR) model has been developed that can be used to study the effect of formulations on skin barrier repair .…”

Section: Introductionmentioning

confidence: 99%

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Topically applied fatty acids are elongated before incorporation in the stratum corneum lipid matrix in compromised skin

Berkers

Dijk

Absalah

et al. 2016

Experimental Dermatology

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In several skin diseases, both the lipid composition and organization in the stratum corneum (SC) are altered which contributes to the impaired skin barrier function in patients. One of the approaches for skin barrier repair is treatment with topical formulations to normalize SC lipid composition and organization. Vernix caseosa (VC), a white cheesy cream on the skin during gestational delivery, has shown to enhance skin barrier repair. In this study, we examined how a fatty acid (FA) containing formulation mimicking the lipid composition of VC interacts with the lipid matrix in the SC. The formulation was applied on ex vivo human skin after SC removal. Subsequently, the ex vivo human skin generated SC during culture. The effect of FA containing formulations on the lipid organization and composition in the regenerated SC was analysed by Fourier transform infrared (FTIR) spectroscopy and liquid chromatography mass spectroscopy (LC/MS), respectively. FTIR results demonstrate that the FAs are intercalated in the lipid matrix of the regenerated SC and partition in the same lattice with the endogenous SC lipids, thereby enhancing the fraction of lipids forming an orthorhombic (very dense) packing in the SC. LC/MS data show that the topically applied FAs are elongated before intercalation in the lipid matrix and are thus involved in the lipid biosynthesis in the skin.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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