UDP-Glucose 6-Dehydrogenase (UGDH)

Abstract

Recent advances in the field of immuno-oncology have brought transformative changes in the management of cancer patients. The immune profile of tumours has been found to have key value in predicting disease prognosis and treatment response in various cancers. Multiplex immunohistochemistry and immunofluorescence have emerged as potent tools for the simultaneous detection of multiple protein biomarkers in a single tissue section, thereby expanding opportunities for molecular and immune profiling while preserving tissue samples. By establishing the phenotype of individual tumour cells when distributed within a mixed cell population, the identification of clinically relevant biomarkers with high-throughput multiplex immunophenotyping of tumour samples has great potential to guide appropriate treatment choices. Moreover, the emergence of novel multi-marker imaging approaches can now provide unprecedented insights into the tumour microenvironment, including the potential interplay between various cell types. However, there are significant challenges to widespread integration of these technologies in daily research and clinical practice. This review addresses the challenges and potential solutions within a structured framework of action from a regulatory and clinical trial perspective. New developments within the field of immunophenotyping using multiplexed tissue imaging platforms and associated digital pathology are also described, with a specific focus on translational implications across different subtypes of cancer.

Comparative Proteomic Analysis of Differentially Expressed Proteins in Amaranthus hybridus L. Roots Under Cadmium Stress

“…The plant cell wall contains large amounts of pectic polymers and hemicelluloses, which are predominantly derived from the precursor UDP-glucuronic acid (UDP-GlcA). The major enzyme for the formation of UDP-GlcA is UDPglucose 6-dehydrogenase, which catalyzes the fourelectron transfer enzyme responsible for the oxidation of the 6-hydroxyl group of UDP-α-D-glucose to produce UDP-α-D-GlcA (Wegrowski and Pitsillides 2014)., Inhibition of UDP-glucose dehydrogenase activity upon Cd exposure has been reported in Cucumis sativus (Kabała et al 2008). UDP-glucuronic acid decarboxylase catalyzes the conversion of UDP-GlcA to UDP-xylose via a decarboxylation reaction.…”