UCNPs-based nanoreactors with ultraviolet radiation-induced effect for enhanced ferroptosis therapy of tumor

Zhang, Ke; Wang, Jing‐Zhi; Lin, Peng; Zhang, Yawen; Zhang, Jinzha; Zhao, Wenbo; Ma, Shenglin; Mao, Chun; Zhang, Shirong

doi:10.1016/j.jcis.2023.07.183

Cited by 8 publications

(4 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[119][120][121] Cellular H 2 O 2 generation generally relies on the amount of glucose and oxygen, which is also an important source of tumor energy. 122 Otherwise, H 2 O 2 exogenous sup-plement materials such as metal peroxides could rapidly release H 2 O 2 in the tumor acid microenvironment. The main problem that needs to be considered is the leakage risk of nanoparticles and the cell biocompatibility of metal ions.…”

Section: Mechanism Of H 2 O 2 -Supplying Materials For Tumor Therapymentioning

confidence: 99%

Advances in H₂O₂-supplying materials for tumor therapy: synthesis, classification, mechanisms, and applications

Zhang,

Li,

Tang

et al. 2024

Biomater. Sci.

View full text Add to dashboard Cite

show abstract

Section: Mechanism Of H 2 O 2 -Supplying Materials For Tumor Therapymentioning

confidence: 99%

Advances in H₂O₂-supplying materials for tumor therapy: synthesis, classification, mechanisms, and applications

Zhang,

Li,

Tang

et al. 2024

Biomater. Sci.

View full text Add to dashboard Cite

show abstract

“…UCNPs-mediated NIR irradiation replenished the intracellular Fe 2+ via the photoreduction of endogenous Fe 3+ . 20 The increased concentration of intracellular Fe 2+ strongly promoted the generation of LPOs, leading to enhanced ferroptosis and improved toxicity to G422 cells.…”

Section: ■ Introductionmentioning

confidence: 99%

“…In this nanocomposite, the loaded DHA was found to be responsible for inducing ferroptosis by inhibiting GPX4 and exerting an antitumor effect with the assistance of Fe 2+ , which significantly decreased the concentration of intracellular Fe 2+ in G422 cells. UCNPs-mediated NIR irradiation replenished the intracellular Fe 2+ via the photoreduction of endogenous Fe 3+ . The increased concentration of intracellular Fe 2+ strongly promoted the generation of LPOs, leading to enhanced ferroptosis and improved toxicity to G422 cells.…”

Section: Introductionmentioning

confidence: 99%

Upconversion Dihydroartemisinin-Loaded Nanocomposites for NIR-Enhanced Ferroptosis of Glioblastoma Cells

Shao,

Zhang,

Xue

et al. 2024

ACS Appl. Nano Mater.

View full text Add to dashboard Cite

Ferroptosis, a unique iron-dependent mode of cell death, has been identified as a potential treatment for glioblastoma (GBM). Dihydroartemisinin (DHA) is a ferroptosis inducer with cytotoxicity that is strongly dependent on intracellular Fe 2+ levels. However, the effectiveness of DHA is limited by low levels of Fe 2+ in tumor cells. To address this issue, a facile strategy was developed by combining near-infrared (NIR)-induced ferrous ion regeneration with DHA in a nanocomposite (ApoE-UPGs-DHA). This nanocomposite synergistically enhanced ferroptosis and offered highly efficient GBM treatment. ApoE-UPGs-DHA were prepared by loading upconversion nanoparticles (UCNPs) and DHA into micelles and subsequently attaching the peptide apolipoprotein E to enable penetration of the blood-brain barrier (BBB) and targeted treatment of GBM. NIR irradiation was applied to induce the regeneration of Fe 2+ from Fe 3+ mediated by ApoE-UPGs-DHA, thereby promoting ferroptosis in G422 glioma cells. Characterization studies confirmed the successful preparation of ApoE-UPGs-DHA, which had a diameter of 82.3 ± 5.8 nm. The nanocomposite demonstrated good GBM targeting ability in vivo and enhanced uptake by the G422 cells in vitro. ApoE-UPGs-DHA were toxic to G422 glioma cells, and this toxicity was further enhanced by NIR irradiation. Mechanistic studies revealed that ApoE-UPGs-DHA treatment led to a decrease in the intracellular Fe 2+ concentration due to the Fenton-like reaction induced by DHA and Fe 2+ . NIR irradiation was transformed into UV light by ApoE-UPGs-DHA, and then, the Fe 3+ generated by the Fenton reaction was photoreduced to Fe 2+ by UV light. The replenished Fe 2+ significantly promoted the generation of lipid peroxides (LPOs), leading to enhanced ferroptosis and toxicity to ApoE-UPGs-DHA-treated G422 glioma cells. Herein, an NIR-responsive Fe 2+ -regenerating nanocomposite was successfully prepared to enhance ferroptosis in G422 glioma cells, suggesting a promising alternative GBM treatment strategy.

show abstract

“…The axial bonds of the platinum(IV) prodrug loaded on UCNPs can be cleaved upon excitation by the high-energy light (UV light), thereby inducing the release of cytotoxic platinum(II) and corresponding ligands, ultimately exerting antitumor activities . Integrating exogenous NIR light irradiation with endogenous stimulus is capable of elevating the reduction efficacy of platinum(IV) prodrugs and reducing the possible side effects in a controllable manner. − …”

Section: Introductionmentioning

confidence: 99%

NIR Light and GSH Dual-Responsive Upconversion Nanoparticles Loaded with Multifunctional Platinum(IV) Prodrug and RGD Peptide for Precise Cancer Therapy

Liu,

Zhu,

et al. 2024

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

Platinum(II) drugs as a first-line anticancer reagent are limited by side effects and drug resistance. Stimuli-responsive nanosystems hold promise for precise spatiotemporal manipulation of drug delivery, with the aim to promote bioavailability and minimize side effects. Herein, a multitargeting octahedral platinum-(IV) prodrug with octadecyl aliphatic chain and histone deacetylase inhibitor (phenylbutyric acid, PHB) at axial positions to improve the therapeutic effect of cisplatin was loaded on the upconversion nanoparticles (UCNPs) through hydrophobic interaction. Followed attachment of DSPE-PEG 2000 and arginine-glycine-aspartic (RGD) peptide endowed the nanovehicles with high biocompatibility and tumor specificity. The fabricated nanoparticles (UCNP/ Pt(IV)-RGD) can be triggered by upconversion luminescence (UCL) irradiation and glutathione (GSH) reduction to controllably release Pt(II) species and PHB, inducing profound cytotoxicity. Both in vitro and in vivo experiments demonstrated that UCNP/Pt(IV)-RGD exhibited remarkable antitumor efficiency, high tumor-targeting specificity, and real-time UCL imaging capacity, presenting an intelligent platinum(IV) prodrug-loaded nanovehicle for UCL-guided dual-stimuli-responsive combination therapy.

show abstract

UCNPs-based nanoreactors with ultraviolet radiation-induced effect for enhanced ferroptosis therapy of tumor

Cited by 8 publications

References 40 publications

Advances in H₂O₂-supplying materials for tumor therapy: synthesis, classification, mechanisms, and applications

Advances in H₂O₂-supplying materials for tumor therapy: synthesis, classification, mechanisms, and applications

Upconversion Dihydroartemisinin-Loaded Nanocomposites for NIR-Enhanced Ferroptosis of Glioblastoma Cells

NIR Light and GSH Dual-Responsive Upconversion Nanoparticles Loaded with Multifunctional Platinum(IV) Prodrug and RGD Peptide for Precise Cancer Therapy

Contact Info

Product

Resources

About

UCNPs-based nanoreactors with ultraviolet radiation-induced effect for enhanced ferroptosis therapy of tumor

Cited by 8 publications

References 40 publications

Advances in H2O2-supplying materials for tumor therapy: synthesis, classification, mechanisms, and applications

Advances in H2O2-supplying materials for tumor therapy: synthesis, classification, mechanisms, and applications

Upconversion Dihydroartemisinin-Loaded Nanocomposites for NIR-Enhanced Ferroptosis of Glioblastoma Cells

NIR Light and GSH Dual-Responsive Upconversion Nanoparticles Loaded with Multifunctional Platinum(IV) Prodrug and RGD Peptide for Precise Cancer Therapy

Contact Info

Product

Resources

About

Advances in H₂O₂-supplying materials for tumor therapy: synthesis, classification, mechanisms, and applications

Advances in H₂O₂-supplying materials for tumor therapy: synthesis, classification, mechanisms, and applications