Ubiquitination in Periodontal Disease: A Review

Abstract

Periodontal disease (periodontitis) is a chronic inflammatory condition initiated by microbial infection that leads to gingival tissue destruction and alveolar bone resorption. The periodontal tissue’s response to dental plaque is characterized by the accumulation of polymorphonuclear leukocytes, macrophages, and lymphocytes, all of which release inflammatory mediators and cytokines to orchestrate the immunopathogenesis of periodontal disease. Ubiquitination is achieved by a mechanism that involves a number of factors, including an ubiquitin-activating enzyme, ubiquitin-conjugating enzyme, and ubiquitin–protein ligase. Ubiquitination is a post-translational modification restricted to eukaryotes that are involved in essential host processes. The ubiquitin system has been implicated in the immune response, development, and programmed cell death. Increasing numbers of recent reports have provided evidence that many approaches are delivering promising reports for discovering the relationship between ubiquitination and periodontal disease. The scope of this review was to investigate recent progress in the discovery of ubiquitinated protein in diseased periodontium and to discuss the ubiquitination process in periodontal diseases.

Genetic Association with Subgingival Bacterial Colonization in Chronic Periodontitis

“…The possible mechanism of association between rs10043775 and changes in the subgingival microbiological pattern is completely uncertain, since there is no direct evidence of FBXO38 association with host response. However, due its putative role in the ubiquitination process, which in turn has been implicated in the immune response, it could exert some impact over periodontal microbiota via this pathway [ 89 ]. However, it is possible that a yet unknown mechanism is responsible for the differential susceptibility to periodontitis demonstrated by our sample, or alternatively that rs10043775 is in linkage disequilibrium with another variant that is truly responsible for the changes in the subgingival microbiological pattern.…”

Biological links in periodontitis and rheumatoid arthritis: Discovery via text‐mining PubMed abstracts

“…They are important regulators of T‐cell and innate immune function through activation of NF‐κB. Ubiquination has been recently implicated in periodontitis . P. gingivalis produces a ubiquitin‐ligase Smurf‐1 dependent degradation of MyD88, an upstream regulator NF‐κB in neutrophils, and results in elevated type‐1 interferon .…”

Periodontal disease and women reproductive health

“…1,2 Periodontal diseases (PDs) include a group of inflammatory diseases characterized by periodontium hard and soft tissues destruction leading to host immune response activation. 3 It has been reported that PDs as one of the two biggest threats to the oral health have a high prevalence in United States and they have been found in nearly half (45.9%) of the population aged 30 years and older. 4,5 Further, it has been revealed that PDs affect up to 15% of the population of childbearing age and some degrees of PDs can be seen in relatively high proportions of pregnant women.…”