überden Einflu\ der Glutaminsäure auf den Stoffwechsel, speziell des Zentralnervensystems

Gruendig, E; Salvenmoser, F.; Bretschneider, R.

doi:10.1007/bf02053403

Cited by 4 publications

(1 citation statement)

References 30 publications

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“…This may be explained in the light of previous work (1,2), in which a decrease observed in glutamic acid was compensated by an augmentation of glycine, serine and related amino acids. There is a correlation between glucose utilisation and glutamic acid level in the CNS; thus, the disturbance of glucose metabolism was reported to produce a decrease in the glutamic acid level in the CNS (12). The reported simultaneous increase in serine and glycine (1,2) occurs only in extrapyramidal syndromes (11).·· Neuroleptics of the phenothiazine type are still studied in connection with their effects onX-DOPA metabolism (13)(14)(15)(16)(17)(18)(19)(20)(21).…”

Section: Discussionmentioning

confidence: 99%

Incorporation of [U- 14 C]Glucose into Metabolites of Brain, Liver and Blood of Rats Pretreated with Reserpine or Phenothiazines

Raheem¹,

Gründig²,

Salvenmoser³

et al. 1979

Clinical Chemistry and Laboratory Medicine

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Summary:Parkinsonism was induced in rats by using phenothiazines (Butyrylperazin and Thioproperazin), (P-group), or reserpine, (R-group). [U-14 C)D-glucose was administered when the symptoms of Parkinsonism had become fully developed. Concentrations and radioactivities of different metabolites were studied in brain, liver and blood serum. 3. Both treatments caused a fall in the amino acid concentration of the blood serum. A rise in the specific radioactivity of blood amino acids was observed in the P^group, while a decrease in specific radioactivity was observed in the R-group. A hyperglycemia was induced in the R-group with reduced specific radioactivity of glucose in both P-and R-groups. A reduction in lipid concentration of blood serum was achieved with an increased specific radioactivity in P-group and decreased radioactivity in R-group.4. The changes in amino acids common to both treatments are also observed in human Parkinsonism. Der Einbau von [i/-14

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Section: Discussionmentioning

confidence: 99%

Incorporation of [U- 14 C]Glucose into Metabolites of Brain, Liver and Blood of Rats Pretreated with Reserpine or Phenothiazines

Raheem¹,

Gründig²,

Salvenmoser³

et al. 1979

Clinical Chemistry and Laboratory Medicine

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Der Einflu� der Verabreichung von Aminos�uren, speziell von L-Dopa und ?-Methyldopa, auf die Zusammensetzung des Liquor cerebrospinalis bei extrapyramidalen Syndromen

Gründig

Gerstenbrand

Bruck

et al. 1969

Deutsche Zeitschrift f. Nervenheilkunde

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Zur Biosynthese von Aminos�uren aus Glukose im Zentralnervensystem beim Parkinsonsyndrom

Gründig

Mayer

Gerstenbrand

1983

Arch Psychiatr Nervenkr

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The incorporation of labelled carbon from glucose U-14C into CSF amino acids was investigated in three patients with Parkinson's disease and in three control persons with comparable age and physical stature. Comparing the specific radioactivities of serum and CSF one can postulate that the labelled amino acids found in the CSF are synthesized mainly by brain tissue. The resorption of glucose into the CNS and therefore the synthesis of amino acids from glucose was more rapid in controls; labelled alanine and glutamine appeared later in the CSF of the patients. As expected, in the controls the specific radioactivity of glutamic acid was found to be higher than that of glutamine, in patients the labelling of glutamine was higher as was that of serine, glycine, aspartic acid and asparagine. From our knowledge concerning the compartmentation of the metabolism of glutamate, we assume that in Parkinsonism the metabolic activity of neurons is reduced but that of astroglia is enhanced.

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überden Einflu\ der Glutaminsäure auf den Stoffwechsel, speziell des Zentralnervensystems

Cited by 4 publications

References 30 publications

Incorporation of [U- 14 C]Glucose into Metabolites of Brain, Liver and Blood of Rats Pretreated with Reserpine or Phenothiazines

Incorporation of [U- 14 C]Glucose into Metabolites of Brain, Liver and Blood of Rats Pretreated with Reserpine or Phenothiazines

Der Einflu� der Verabreichung von Aminos�uren, speziell von L-Dopa und ?-Methyldopa, auf die Zusammensetzung des Liquor cerebrospinalis bei extrapyramidalen Syndromen

Zur Biosynthese von Aminos�uren aus Glukose im Zentralnervensystem beim Parkinsonsyndrom

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