Über Thio‐tetronsäure und Derivate

Abstract

IV. C a e s i u m -h e x a b r o r n o -o s m e a t , CP:! OsBrG.Auch diese AnlagerungsverbindunR ist so schwer loslich, dal3 bei ihrer Bildung fast quantitative Pallung eintritt. Dns Reaktionsprodukt, das sich sowohl bei gewohnlicher Temperatur als auch bei Siedehitze sogleich ausscheidet, bildet ein dunkel rotbraunes, in Wasser n i e in verdunnter Bromwasserstoffsaure so gut wie unlosliche?, mikrokrystallinisches Pulver. 0.15'27 g Sbst.: 0.0311 g 0 s . -0.1058 g Sbst.: 0.0415 g CS,SO~. -0.1007 g Sbst.: 0.0201 g OS, 0.0384 g CS~SOI. Cp~OsBr,j. Ber. 0 s 20.39, Cs 28.37.Gef. 20.37, 19.96, x 28.79, 27.93. Die Untersuchung, bei der, wie auch hier mit Dank erwiihnt sei, Mittel BUS der Jubilaumsstiltung der deutschen lndustrie zur Verfigung standen, wird nach verschiedenen Richtungen hin fortgesetzt. S t u t t g a r t , am 15. Juni 1913. 208. Erioh Benary: tfber Thio-tetronetiure und Derivate.

Syntheses of Combretastatins D-1, D-2, and D-4 via Ring Contraction by Flash Vacuum Pyrolysis

“…The volatiles were removed under reduced pressure, and the crude product was purified by column chromatography (cyclohexane/EtOAc 5:1) to yield 7 (7.91 g, 32.8 mmol, 97%) as colorless crystals of mp 41−44 °C [lit. 36 (35), 181 (37), 102 (100), 75 (26), 51 (31).…”

“…A mixture of alcohol 9 (2.80 g, 9.84 mmol), CH 2 Cl 2 (90 mL), S -acetylthioacetic acid (1.45 g, 10.8 mmol), EDC (2.08 g, 10.8 mmol), and DMAP (602 mg, 4.94 mmol) was stirred for 3 h at room temperature and then washed with 0.1 M citric acid (50 mL) and brine (100 mL), dried over Na 2 SO 4 , and concentrated under reduced pressure. The crude product was purified by column chromatography (cyclohexane/ethyl acetate 3:1) to yield 10 (2.65 g, 6.63 mmol, 67%) as a colorless oil.…”

Developments in the Synthesis of 3-Acyltetramic Acid Natural Products

“…The synthetic methodology for 3-acyltetramic acids has been evolved by applying well-established synthetic methods for accessing structurally related 3-acyltetronic acids and 3-acylthiotetronic acids [43][44][45][46][47][48]. Markopoulou et al have demonstrated successful application of a method reported by Benary for 3-acylthiotetronic acids [43] as the one for 3-acyltetramic acids.…”

Synthesis and medicinal chemistry of selected antitubercular natural products and natural product derivatives

“…12 In 1913, prior to the isolation and structure elucidation of 7, Benary described the synthesis of the thiolactone ring system, the key intermediate of 7. 13 This synthesis protocol was utilized by Wang and Salvino, 14 Vipan kumar Ph.D, has been working as an Assistant Professor in the Department of Chemistry, Guru Nanak Dev University, Amritsar since 2009. He obtained his Ph.D with Prof. MP Mahajan, in the Department of Applied Chemistry, GNDU.…”