Über präsenile Verblödungen

Alzheimer's Disease With Acne Rosacea in One of Identical Twins

“…Those first affected were the children of first-cousin marriages: the appearance of the character in the subsequent generation in each pedigree can be explained only by the mating of a homozygous affected with a heterozygous normal, a circumstance indicative of a relatively high rate of heterozygous normals in the population. The family histories of cases described by Schottky (1932), Grunthal and Wenger (1939), van Bogaert, Maere, and de Smedt (1940), who described two cases, and Essen-Moller (1946) all admit of transmission of an autosomal or partially sex-linked dominant gene, there being in each instance a " vertical " distribution ofaffected persons, of whom all had one affected parent so far as could be traced.…”

“…At a Royal Society of Medicine discussion on presenile dementia in 1932, for instance, Critchley could express legitimate surprise when two of the speakers cited familial cases of Alzheimer's disease and could point out with accuracy that no such familial cases had previously been reported in the literature. In that same year, however, Schottky (1932) described the occurrence of Alzheimer's disease in a father and daughter, and from then onwards sporadic cases of parent-child incidence and/or sibling incidence have continued to be reported. The most recent is that described by Essen-M6ller (1946) and concerns a father, son, and daughter all of whom developed Alzheimer's disease in their fourth decade.…”

Über Spätformen der Alzheimerschen Krankheit und ihre Beziehung zur senilen Demenz

“…Die Auffassungen über den Erbgang der bei den Erkrankungen sind zwar noch kontrovers. Das häufige Auftreten der Alzheimerschen Krankheit in mehreren aufeinanderfolgenden Generatio nen und die Seltenheit reiner Geschwisterfälle lässt aber in erster Linie an einen dominanten Erbgang denken; auch für die senile Demenz wird vor allem von Larsson [29] [32], Koch [25], Schottky [46], Loewenberg [31], und Delay und Brion [14] …”

Alzheimer's Disease: Approaches to Pathogenesis in the Genomic Age

“…The first AD family presenting with an apparent Mendelian pattern of inheritance was described in 1932 (Schottky, 1932). In more modern times a family was reported with 51 affected persons in 8 generations (Nee et al, 1983).…”