Über Spätformen der Alzheimerschen Krankheit und ihre Beziehung zur senilen Demenz

Läuter, H.

doi:10.1159/000278603

Cited by 11 publications

(14 citation statements)

References 8 publications

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“…Ninety-three per cent of moderately and 100% of severely demented patients had parietal symptoms in the EAD group, in contrast to 58% of moderately and 50% of severely demented patients in the LAD group (Table 2). This frequency distribution is in agreement with Lauter (1970), who found parietal symptoms in 85% of EAD and 50% of LAD patients, and with Constantinidis (1978), who found parietal symptoms in 90% of EAD and 67% of LAD patients.…”

Section: Differences In Clinical Symp Tomatology Between Early and Lasupporting

confidence: 92%

Presence of parieto‐temporal symptomatology distinguishes early and late onset Alzheimer's disease

Blennow

Wallin

Gottfries

1991

Int J Geriat Psychiatry

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SUMMARYThirty-one patients with early onset Alzheimer's disease (EAD) and 44 with late onset Alzheimer's disease (LAD) were examined with regard to symptoms reflecting disturbances in various brain regions, ie frontal, parietal and subcortical symptoms. Clinical vascular factors were recorded. The albumin ratio (CSF albuminherum albumin) was used as a measure of the blood-brain barrier (BBB) function. Parietal symptoms were more common in EAD than in LAD, both among mildly demented patients (60% in EAD, 10% in LAD; p < 0.01) and among moderately demented patients (93% in EAD, 58% in LAD; p < 0.01). Among moderately and severely demented patients, predominance of parietal symptoms was more common in EAD (93%) than in LAD (26%) (p < 0.Olj.Patients with predominant parietal symptoms had significantly lower age at onset, absence of concomitant diseases, and normal BBB function, and we suggest that they constitute the classical AD group. A symptom profile without parietal predominance was found to be associated with higher age at onset, presence of clinical vascular factors and impaired BBB function, suggesting that age-related and/or vascular factors may influence the symptomatology in this group.KEY WORDS-Alzheimer's disease, early onset, late onset, parieto-temporal symptomatology, blood-brain barrier.

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Section: Differences In Clinical Symp Tomatology Between Early and Lasupporting

confidence: 92%

Presence of parieto‐temporal symptomatology distinguishes early and late onset Alzheimer's disease

Blennow

Wallin

Gottfries

1991

Int J Geriat Psychiatry

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“…The rCBF pattern was in accordance with the classic temporo-parietal AD pattern in combination with bilateral frontal flow decreases, a common pattern in older individuals with more advanced AD [30,37,38]. The bilateral, partially temporo-parietal location of the infarcts could have further contributed to the AD symptomatology.…”

Section: Discussionsupporting

confidence: 62%

Contributions of Other Brain Pathologies in Dementia with Lewy Bodies

Londos¹,

Passant²,

Risberg³

et al. 2002

Dement Geriatr Cogn Disord

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The clinical picture with its pathological correlate was analysed in 16 patients fulfilling consensus criteria for dementia with Lewy bodies (DLB). The cases were part of a larger cohort (n = 200) of patients within a prospective longitudinal study of dementing disorders. Six cases exhibited not only Lewy bodies (LBs) but also other brain pathologies such as Alzheimer changes, multiple infarcts or complete and incomplete white matter infarcts. Degeneration of the nucleus basalis of Meynert and substantia nigra was also seen. The 10 cases without LBs all had Alzheimer changes. In 7 cases, these changes were combined with mainly incomplete frontal white matter infarcts. However, the degeneration of brain stem nuclei was less pronounced in these cases. Symptoms such as fluctuations in cognition, falls and episodic confusion appeared in association with arterial hypotension, which developed during the course of dementia in almost all the 16 cases. The majority of the cases were treated with neuroleptics and other potentially hypotensive medication. This study shows that multiple and different pathological features may contribute to a clinical symptom constellation as in DLB. The case study approach reveals the complexity of the clinico-pathological relationships in dementia that might otherwise be lost in the analysis of larger group data.

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“…In selective incomplete white matter infarction there are certain distinguishing characteristics: (i) there is an arteriolosclerosis confined to the incomplete infarction, the smallest vessels being severely or almost Completely occluded with mural thickening by non-amyloid fibrohyaline material: (ii) it is not accompanied by ischaemic grey matter changes: (iii) it occurs mainly in non-hypertensive and hypotensive subjects. Dementia of Alzheimer's type with concomitant selective incomplete white matter infarction is thus not to be confused with the group of mixed Alzheimer cerebrovascular dementia or Alzheimer multi-infarct dementia as previously defined (Lauter 1970, Tomlinson, Blessed & Roth 1970.…”

Section: Introductionmentioning

confidence: 91%

White matter changes in dementia of Alzheimer's type: the difference in vulnerability between cell compartments

1990

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White matter changes in dementia of Alzheimer's type: the difference in vulnerability between cell compartmentsStructural white matter changes were found to be common in dementia of Alzheimer's type. A neuropathological investigation was undertaken in order to characterize and quantify these white matter changes. The tissue changes were compared with those in white matter in normal control cases and in complete white matter infarcts. Our results support the hypothesis that Keywords: Alzheimer's disease, white matter, incomplete infarction, axonal damage, reactive gliosis the white matter lesion seen in dementia of Alzheimer's type is due to incomplete infarction involving both axons and myelin and is a result of mild ischaemia. In mild ischaemia. the myelin compartment appears to be the most vulnerable. We have termed the lesion selective incomplete white matter infarction.

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Über Spätformen der Alzheimerschen Krankheit und ihre Beziehung zur senilen Demenz

Cited by 11 publications

References 8 publications

Presence of parieto‐temporal symptomatology distinguishes early and late onset Alzheimer's disease

Presence of parieto‐temporal symptomatology distinguishes early and late onset Alzheimer's disease

Contributions of Other Brain Pathologies in Dementia with Lewy Bodies

White matter changes in dementia of Alzheimer's type: the difference in vulnerability between cell compartments

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