Über Oxyphenyl‐alkylamine und Dioxyphenyl‐alkylamine

Mannich, C.; Jacobsohn, W.

doi:10.1002/cber.19100430126

Cited by 95 publications

(26 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is likely that these counterintuitive effects of dopamine largely reflect the stimulation of non-cardiac tissue metabolism. Dopamine was first synthesized one century ago (22) and has been widely used for 40 years (1-7) to augment cardiac performance in different forms of low cardiac output state. Dopamine has differential agonist effects on the 3 main types of adrenergic receptors that are dose dependent.…”

Section: Discussionmentioning

confidence: 99%

Adverse Effects of Dopamine on Systemic Hemodynamic Status and Oxygen Transport in Neonates After the Norwood Procedure

Zhang

Holtby

et al. 2006

Journal of the American College of Cardiology

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Adverse Effects of Dopamine on Systemic Hemodynamic Status and Oxygen Transport in Neonates After the Norwood Procedure

Zhang

Holtby

et al. 2006

Journal of the American College of Cardiology

View full text Add to dashboard Cite

show abstract

“…It was originally synthesized in 1910 because of the strong physiological effects, observed for other phenolic bases like epinephrine [12,13], but due to its comparatively low effect on arterial blood-pressure it was mostly overlooked. The first time DA was found to occur in an organism was as a pigment-building metabolite in the plant Sarothamnus scoparius [14].…”

Section: On the Origin Of Dopamine Researchmentioning

confidence: 99%

Complexity of dopamine metabolism

2013

View full text Add to dashboard Cite

Parkinson’s disease (PD) coincides with a dramatic loss of dopaminergic neurons within the substantia nigra. A key player in the loss of dopaminergic neurons is oxidative stress. Dopamine (DA) metabolism itself is strongly linked to oxidative stress as its degradation generates reactive oxygen species (ROS) and DA oxidation can lead to endogenous neurotoxins whereas some DA derivatives show antioxidative effects. Therefore, DA metabolism is of special importance for neuronal redox-homeostasis and viability.In this review we highlight different aspects of dopamine metabolism in the context of PD and neurodegeneration. Since most reviews focus only on single aspects of the DA system, we will give a broader overview by looking at DA biosynthesis, sequestration, degradation and oxidation chemistry at the metabolic level, as well as at the transcriptional, translational and posttranslational regulation of all enzymes involved. This is followed by a short overview of cellular models currently used in PD research. Finally, we will address the topic from a medical point of view which directly aims to encounter PD.

show abstract

“…DA is found in both peripheral and central tissues; however, concentrations of DA are generally much greater in the CNS than in the periphery. In the periphery, DA is found in: (1) postganglionic adrenergic neurons where in most instances, excepting certain sympathetic n e r v e~, '~ the relative concentration is quite low; (2) the heart,I5 perhaps concentrated in the region of the sino-atrial nodeI6; (3) adrenal glandI7; and (4) other tissues, e.g., mammalian kidney, pituitary gland, lung, bronchi, liver, jejunum, colon, parotid gland, carotid body, and pancreas where it is often associated with noninnervated structures. 's Labeled DA is distributed in peripheral organs of guinea pigs following i.v.…”

Section: Natural Occurrence and Distribution Of Dopaminementioning

confidence: 99%