Über Oxydationsprozesse im Blut

Morawitz, P.

doi:10.1007/bf01909656

Cited by 54 publications

(4 citation statements)

References 5 publications

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“…The blood of patients with chronic myelogenous leucemia continued to use oxygen in the microspirometer longer than that of normal individuals, and the hemoglobin, in the leucemic bloods, became desaturated even though exposed to air. 5. In blood in which the bulk of the cells were immature and the mature cells few, the oxygen consumption was lower than in blood in which the mature cells predominated.…”

Section: Sum2~ar¥ and Conclusionmentioning

confidence: 93%

Cell Respiration Studies

Daland

Isaacs

1927

Journal of Experimental Medicine

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The observation by Warburg (1) that the amount of oxygen used by a slice of Flexner-Jobling rat carcinoma was less than that absorbed by such normal tissues as liver or kidney, has opened the way for the further study of the metabolism of tumor and other rapidly growing cells. The immature white blood ceils of myelogenous leucemia resemble somewhat those of the malignant neoplasms in their growth rate and behavior, and response to exposures to Roentgen rays. They serve as excellent material for the study of oxygen consumption because of their availability and the ease with which they can be manipulated in vitro.Patients with leucemia frequently have an elevated basal metabolic rate, particularly when the blood contains many immature cells (Riddle and Sturgis (2)). The possibility of a causal relationship between the rate of oxygen absorption by the patient and the degree of maturation of the blood cells presents a problem toward the solution of which this study of cell respiration in the microspirometer offers some data.The studies reported here include observations on the blood of normal individuals, a patient with a leucocytosis from sepsis, and patients with chronic myelogenous leucemia in various stages of the disease.

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Section: Sum2~ar¥ and Conclusionmentioning

confidence: 93%

Cell Respiration Studies

Daland

Isaacs

1927

Journal of Experimental Medicine

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“…The possible sources of error in determining the oxygen consumption of blood have been discussed by Morawitz (7), by Warburg (3), and by Harrop (5) and consequently need little consideration here. The duration of the experiments carried out by these investigators frequently extended over a period of many hours and consequently necessitated an aseptic technique.…”

Section: Methodsmentioning

confidence: 99%

“…This chocolate brown color of the blood persists for 48 to 72 hours before finally passing off, its termination being roughly coincident with the point of greatest severity in the anemia. The recovery from the anemia takes place fairly rapidly at first and then more slowly, being characterized by somewhat considerable oscillations in the red cell counts, a condition previously observed in the phenylhydrazine anemia of rabbits by Morawitz (7). Both fowls were injected with phenylhydrazine hydrochloride 0.5 per cent solution in saline (20 nag.…”

Section: Metabolism In Phenflhydrazine Anemiamentioning

confidence: 99%

Factors Influencing the Respiration of Erythrocytes

Wright

1930

Journal of General Physiology

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1. The oxygen consumption of normal and "primitive red cells" of fowls' blood has been determined at intervals in the course of an anemia produced by the injection of phenylhydrazine. The "primitive red cells" have an oxygen consumption at least twenty to twenty-five times greater than the normal red cells. 2. Suspension of the cells derived from the blood in anemia in sodium chloride solutions of various concentrations has comparatively little effect upon the oxygen consumption of the cells. 3. The red cells from anemic blood are sensitive to variations in the reaction of the medium in which they are suspended. The maximum oxygen consumption, after addition of a saline solution containing variable amounts of acid to the blood, took place at pH 7.75. They appeared somewhat more sensitive to variations on the acid side of this reaction than on the alkaline. 4. Addition of glucose to the medium increased the oxygen consumption of the cells. Their metabolism in a physiological saline solution containing 0.6 per cent of glucose was 15 per cent higher than in one in which no glucose was present. 5. Certain amino acids in low concentrations had little effect on oxygen consumption, though at higher concentrations some of them definitely diminished it.

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“…It has been demonstrated (37) that in diseases of the hematopoietic system characterized by great bone marrow activity and the releasing into the blood stream of great numbers of young and even immature red blood corpuscles there is a marked increase in the amount of sugar glycolyzed. In this connection it is interesting to note that Harrop (34), Morawitz (38) and Derra (39) have reported the increased use of oxygen by immature erythrocytes. No attempt was made in this study to correlate the rate of glycolysis and the oxygen consumption but, in view of the conclusions drawn by Glover, Daland and Schmitz (40) regarding the oxygen utilization and glycolytic rate of normal and leukemic leucocytes, such a study is desirable.…”

mentioning

confidence: 90%

A Study of Glycolysis

Barer

1931

J. Clin. Invest.

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Über Oxydationsprozesse im Blut

Cited by 54 publications

References 5 publications

Cell Respiration Studies

Cell Respiration Studies

Factors Influencing the Respiration of Erythrocytes

A Study of Glycolysis

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