Über Juvenile Maligne Nephrosklerose Und Ihr Verhältnis Zu Störungen in Der Nierenentwicklung

Ask‐Upmark, Erik

doi:10.1111/j.1600-0463.1929.tb06098.x

Cited by 116 publications

(10 citation statements)

References 11 publications

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“…Renal segmental hypoplasia or Ask-Upmark kidney has first been described in 8 patients in 19291 Histologically, the affected kidney appears small and contains segments with a decreased number of pyramids, atrophic tubules and no glomeruli. A thin cortex overlies dilated calyces 2 3.…”

Section: Discussionmentioning

confidence: 99%

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A 3-year old girl with seizures, hypokalemia and metabolic alkalosis

Harnisch¹,

Leertouwer²,

Cransberg³

et al. 2010

Case Reports

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A 3-year-old girl presented to the emergency department with seizures, low-grade fever and vomiting. She had tachycardia and a slow capillary refill. Blood pressure could not be measured. Because of suspected sepsis and/or meningo-encephalitis, broad spectrum antibiotics and antiviral medication were given together, along with volume expansion and anticonvulsive therapy. A few hours later, after a second seizure, the blood pressure was extremely high (156/116 mm Hg). The girl was treated with anticonvulsants and intravenous antihypertensive agents. MRI of the brain showed signs of posterior reversible encephalopathy syndrome. Cultures of blood and cerebrospinal fluid remained sterile. Further investigation into the cause of the malignant hypertension revealed hypokalemia, metabolic alkalosis and extremely high plasma renin activity, caused by a rare renal abnormality: bilateral renal segmental hypoplasia or Ask-Upmark kidneys.

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Section: Discussionmentioning

confidence: 99%

“…The lesion is generally discovered during childhood or adolescence and is mostly found in females 2. Presenting symptoms are hypertension, haematuria and loin pain 1 2 4. The majority of cases of Ask-Upmark kidneys are unilateral, although bilateral cases have been described 2 5.…”

Section: Discussionmentioning

confidence: 99%

A 3-year old girl with seizures, hypokalemia and metabolic alkalosis

Harnisch¹,

Leertouwer²,

Cransberg³

et al. 2010

Case Reports

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“…Ask‐Upmark kidney (AUK) is a complex anomaly first described in 1929. It is characterized by renal segmental hypoplasia . Several reports support the role of vesicoureteral reflux (VUR), either in utero or in early childhood, in the development of the renal defects.…”

mentioning

confidence: 99%

“…It is characterized by renal segmental hypoplasia. 1 Several reports support the role of vesicoureteral reflux (VUR), either in utero or in early childhood, in the development of the renal defects. Clinically, AUK presents as a pediatric or adolescent entity usually associated with hypertension, recurrent urinary tract infections (UTI), proteinuria, or reduced renal function.…”

mentioning

confidence: 99%

“…The complex anomaly is frequently unilateral, and our case also presented swelling of the lower limbs and renal complications on the right side. However, bilateral symmetrical and asymmetrical hypoplasia has also been observed, 1,4 and cases of intrarenal aneurysm have been reported in association with segmental hypoplasia. 5 From these reports, we speculated the existence of structural abnormalities or vascular malformations in the left kidney, as the patient continued to have hematuria and renal dysfunction even after right kidney extraction.…”

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