various parts of the nervous system, notably the brain, after irradiation has been carried out to a considerable extent in the uterus and other parts of the body. As regards the prog¬ nosis of this particular case, it will be noted that the recur¬ rence in the flap is now stationary following massive doses of radium used at one month intervals. However, it is to be anticipated that there will be an invasion. Mosher has pointed out that there will probably be a little invasion of the anterior ethmoid cells, and probably of the antrum.It occurred to us that acute or chronic ulcers of the stomach might be produced on the basis of the "Arthus phenomenon," or "local anaphylaxis," studied recently in detail by Opie.1 METHODS Rabbits were injected with a protein until a skin ulcer was obtained. The specific protein was then injected aseptically into the gastric mucosa.Appearance at site of injection, five days after, in Dog 4, which was sensitized to egg albumin, and given an injection of a provocative dose into the stomach pouch after twenty-eight days. The ulcer was 1.8 byDogs with a pyloric pouch2 were sensitized to a protein. The provocative dose was injected into the mucosa of the pouch, and into the adjacent skin.The precipitin titer of the blood was followed in both series of experiments.
RESULTSThe gastric mucosa of the rabbits killed at varying intervals presented the following sequence of pathologic changes at the site of injection: (1) local passive hyperemia and edema in from one to two days after injection of the specific protein into the gastric mucosa;(2) induration and necrosis in from two to five days after; (3) ulceration in from three to six days, and (4) 1. Opie, E. L.: Inflammatory healing with papillomatous overgrowth after twelve days. In one rabbit, an ulcer was still present thirtythree days after. Positive results were obtained with egg albumin, beef protein, oat protein, edestin and horse serum.In dogs, since the reaction in the mucosa can be observed ad libitum, the pathologic changes can be more accurately described. Within two minutes after injection of the provocative dose, the pouch contracts violently and everts ; the mucosa becomes cyanotic and markedly edematous. The next day, at the site of injection, there is a large, bluish black, dried area defi¬ nitely limited by a thin line of active hyperemia. On the third day, the central portion of the area turns grayish yellow. By the sixth day, the necrotic mucosa has sloughed out, leaving a punched out ulcer with a granulating base. The edges of the ulcer gradually turn in, and healing is complete in from twenty-one to thirty days. Positive results were obtained with egg albumin, beef protein, oat protein, edestin and squash seed globulin.A second injection of the protein within three days gave no reaction ; within from three to seven days it yielded a second ulcer, and after from seven to ten days only a general reaction. The skin reaction was positive, but quite mild, being limited to a slight transient edema. CONCLUSION Acute ulcers o...