Über Glomerulosklerose

Fahr, Th.

doi:10.1007/bf02593941

Cited by 38 publications

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“…The nature of these renal changes remains obscure. However, the similarity of staining properties of the arteriolar and exudative lesions and the central areas of the nodular lesions to each other, and the elose resemblance in appearance and situation of the glomerular lesions to some forms of amyloidosis (Sirnon, 1940 ;Fahr, 1942;Bogliolo, 1946), suggest that a common feature is the deposition of abnormal protein material in certain sites in the kidney. In some cases such material may line endothelial surfaces, in others permeate and replace the vessel walls, while in still others it may accumulate between denser structures.…”

Section: Discussionmentioning

confidence: 99%

A Biopsy Study of the Kidney in Diabetes Mellitus

Hp¹,

Es²,

Ra³

1954

Australasian Annals of Medicine

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Section: Discussionmentioning

confidence: 99%

A Biopsy Study of the Kidney in Diabetes Mellitus

Hp¹,

Es²,

Ra³

1954

Australasian Annals of Medicine

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“…Kimmelstiel y Wilson consideraron a los citados depósitos como extracapilares, es decir, situados en el mesangio intercapilar (hoy día no admisible) y por ello denominaron al cuadro histológico "glomeruloesclerosis interca pilar". Este parecer fue, entre otros, compartido por Fahr 18 , Me Manus 35 y Scapellato 45 • Fueron más ta! 'de Allen 1 y Bell 4 • 5 los primeros en sostener la tesis opuesta : en vez de un acumulo "intercapilar" se trataría de un engrosamiento nodular de la propia pared vascular, siendo por tanto el depósito "intracapilar".…”

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Glomeruloesclerosis diabética: Problemas actuales

Bueno

2017

revista-de-medicina

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“…In addition to the nodular lesion (Kimmelstiel and Wilson, 1936) and the diffuse lesion (Fahr, 1942;Laipply, Eitzen, and Dutra, 1944) the renal glomeruli of diabetics may contain deposits of eosinophilic, hyaline, or granular material having some of the staining reactions of fibrin. These deposits are not specific for diabetes since similar lesions may be found in a variety of renal conditions.…”

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confidence: 99%

Exudative lesions in diabetes mellitus

Horsfield

Lannigan

1965

Journal of Clinical Pathology

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SYNOPSIS Exudative lesions and capsular drops have been examined in a renal biopsy series of 25 diabetics and a post-mortem series of 100 consecutive diabetics. Electron microscopy of a capsular drop and an exudative lesion is described. Exudative lesions were found in 480% of the biopsies and 47 % of the necropsy material. Capsular drops were found in 60 % of the biopsies and 29 % of the necropsy material. No correlation with age, proteinuria, hypertension, or uraemia was noted. The incidence of both types of lesion increased with the known duration of the diabetes.In addition to the nodular lesion (Kimmelstiel and Wilson, 1936) and the diffuse lesion (Fahr, 1942;Laipply, Eitzen, and Dutra, 1944) the renal glomeruli of diabetics may contain deposits of eosinophilic, hyaline, or granular material having some of the staining reactions of fibrin. These deposits are not specific for diabetes since similar lesions may be found in a variety of renal conditions. Most of the previous descriptions have been from post-mortem material and it has been generally considered that the deposits were terminal. Similar lesions have been found in renal biopsy specimens from diabetics of all ages and severity and the incidence is much higher than might be expected. This communication deals with a series of renal biopsies from 25 diabetics and a series of post-mortem specimens from 100 consecutive cases of diabetes mellitus.The term 'exudative lesion' was used by Hall (1952) MATERIALS AND METHODSBIOPSY SERIES Twenty-five patients were selected aged between 12 and 54 years and of varying duration of diabetes since diagnosis. The earliest biopsy was carried out three weeks after the onset of acute diabetes and the latest 28 years after diagnosis. The patients had varying severity of diabetes, many had proteinuria, and a few were mildly hypertensive; none were uraemic.The renal biopsy material, obtained by the method of Muehrcke, Kark, and Pirani (1955), was fixed in formolcorrosive and serial sections taken almost completely through the specimens. These were stained routinely with haematoxylin and eosin, periodic acid Schiff, and Van Gieson's fluid. Several of the biopsies were split and one part was fixed in 1 % buffered osmium tetroxide for 30 to 60 minutes and embedded in methacrylate for electron microscopy. In one of these specimens a capsular drop and an exudative lesion within a hyalinized glomerulus were located and examined on a Siemens series 6 electron microscope.

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Über Glomerulosklerose

Cited by 38 publications

References 1 publication

A Biopsy Study of the Kidney in Diabetes Mellitus

A Biopsy Study of the Kidney in Diabetes Mellitus

Glomeruloesclerosis diabética: Problemas actuales

Exudative lesions in diabetes mellitus

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