Über eine eigenartige Erkrankung der Maculagegend

Rieger, H.

doi:10.1007/bf01854742

Cited by 10 publications

(2 citation statements)

References 3 publications

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“…What is more, the accumulation of lipid granules in glia, besides notorious Aβ deposition and tau aggregates, was highlighted with the examination of Auguste Deter's brain (the first described AD patient), suggesting a possible involvement of perturbations of lipid metabolism in AD pathology 159,160 . Altered lipid metabolism has subsequently been identified as playing a significant role in the pathogenesis of AD 161–170 …”

Section: Pathological Lipid Alterations and Lipid‐related Therapeutic...mentioning

confidence: 99%

Astrocytic functions and lipid metabolism: Correlations and therapeutic targets in Alzheimer's disease and glioblastoma

Zhang,

Gao,

Yang

et al. 2024

Clinical and Translational Dis

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BackgroundThe brain is a central key organ of the body containing the second highest lipid content only after adipose tissue. Lipids as the main structural components of biological membranes play important roles in a vast number of biological processes within the brain such as energy homeostasis, material transport, signal transduction, neurogenesis and synaptogenesis, providing a balanced cellular environment required for proper functioning of brain cells. Lipids and their metabolism are of great physiological importance in view of the crucial roles of lipids in brain development and function. Astrocytes are the most abundant glial cells in the brain and involved in various processes including metabolic homeostasis, blood brain barrier maintenance, neuronal support and crosstalk.ResultsDisturbances in lipid metabolism and astrocytic functions may lead to pathological alterations associated with numerous neurological diseases like Alzheimer's disease (AD) recognised as the most frequent cause of dementia leading to major progressive memory and cognitive deficits as well as glioblastoma (GBM) known as the most aggressive malignant brain tumour with a poor prognosis.ConclusionsHerein, we not only review the level and role of altered lipid metabolism in correlation with astrocytic function and astrocyte‐neuron crosstalk in AD and GBM, but also discuss important lipid‐related metabolites and proteins participating in possible mechanisms of pathologically dysregulated lipid metabolism, offering potential therapeutic targets in targeted molecular therapies for AD and GBM.

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Section: Pathological Lipid Alterations and Lipid‐related Therapeutic...mentioning

confidence: 99%

Astrocytic functions and lipid metabolism: Correlations and therapeutic targets in Alzheimer's disease and glioblastoma

Zhang,

Gao,

Yang

et al. 2024

Clinical and Translational Dis

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“…Reihe von Erkrankungen in Frage (Tabelle 2). Die zentrale hamorrhagische Chorioretinopathie (Rieger, 1939;Pau, 1968;Saari, 1977;F/age und Mitarbeiter, 1977) ist in dieser Tabelle nicht mit aufgenommen worden, da hierbei regelmaBig die multifokalen Herde in der Penpherie fehlen. Erst die Kombination der zentralen, subretinalen Neovaskularisation mit den peripheren Veränderungen läl3t an das POHS denken, da diese entscheidend für die ophthalmoskopische Diagnose sind und audi isoliert ohne Makulaläsion vorkommen (Ganley und Mitarbeiter, 1973b).…”

Section: Differentialdiagnostisch Kommen Eineunclassified

Untersuchungen zum sogenannten „okulären Histoplasmose-Syndrom”*

Behrens–Baumann

Ecker²,

Vogel³

1988

Klin Monatsbl Augenheilkd

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The authors describe seven patients presenting with ophthalmoscopic findings typical of "presumed ocular histoplasmosis syndrome." However, no humoral antibodies could be demonstrated. Moreover, the results of skin tests were all negative even after "boostering." Hence, the diagnosis of ocular histoplasmosis had to be ruled out. Tests for listeriosis, lues, leptospirosis, ornithosis, Toxocara canis, toxoplasmosis, Larva migrans, and Candida albicans were also negative. There are evidently other, so far unknown, agents which lead to an ophthalmoscopic picture that mimics ocular histoplasmosis with its typical "punched-out lesions" and central hemorrhagic chorioretinopathy. One of these agents may be Epstein-Barr virus, because two of six patients had increased antibody levels of Epstein-Barr nuclear antigen and early antigen, indicating an active or persistent state of viral infection.

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Folgezustände nach einseitiger exsudativer hämorrhagischer Maculopathie

Hübner¹,

Thiel²

1975

Erkrankungen Der Macula

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Über eine eigenartige Erkrankung der Maculagegend

Cited by 10 publications

References 3 publications

Astrocytic functions and lipid metabolism: Correlations and therapeutic targets in Alzheimer's disease and glioblastoma

Astrocytic functions and lipid metabolism: Correlations and therapeutic targets in Alzheimer's disease and glioblastoma

Untersuchungen zum sogenannten „okulären Histoplasmose-Syndrom”*

Folgezustände nach einseitiger exsudativer hämorrhagischer Maculopathie

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