Astrocytic functions and lipid metabolism: Correlations and therapeutic targets in Alzheimer's disease and glioblastoma

Abstract

BackgroundThe brain is a central key organ of the body containing the second highest lipid content only after adipose tissue. Lipids as the main structural components of biological membranes play important roles in a vast number of biological processes within the brain such as energy homeostasis, material transport, signal transduction, neurogenesis and synaptogenesis, providing a balanced cellular environment required for proper functioning of brain cells. Lipids and their metabolism are of great physiological importance in view of the crucial roles of lipids in brain development and function. Astrocytes are the most abundant glial cells in the brain and involved in various processes including metabolic homeostasis, blood brain barrier maintenance, neuronal support and crosstalk.ResultsDisturbances in lipid metabolism and astrocytic functions may lead to pathological alterations associated with numerous neurological diseases like Alzheimer's disease (AD) recognised as the most frequent cause of dementia leading to major progressive memory and cognitive deficits as well as glioblastoma (GBM) known as the most aggressive malignant brain tumour with a poor prognosis.ConclusionsHerein, we not only review the level and role of altered lipid metabolism in correlation with astrocytic function and astrocyte‐neuron crosstalk in AD and GBM, but also discuss important lipid‐related metabolites and proteins participating in possible mechanisms of pathologically dysregulated lipid metabolism, offering potential therapeutic targets in targeted molecular therapies for AD and GBM.

DHM/SERS reveals cellular morphology and molecular changes during iPSCs-derived activation of astrocytes

“…The RhoA-ROCK signaling pathway is a key pathway that regulates the stellate morphology of flattened astrocytes and has an important impact on multiple biological processes, including cell skeleton formation, migration, and adhesion [ 39 – 41 ]. The large reduction in the projected area of the cell may be related to changes in intracellular lipids, since lipids, as the main structural components of biological membranes, play an important role in a large number of biological processes, such as energy homeostasis, material transport, signal transduction, neurogenesis, and synaptogenesis [ 42 ]. Phospholipids, as the most abundant category of cell membrane lipids, are crucial for the maintenance, repair, and function of neural cells [ 43 ].…”