DHM/SERS reveals cellular morphology and molecular changes during iPSCs-derived activation of astrocytes
Xiaoya Bu,
Liwei Yang,
Xianxin Han
et al.
Abstract:The activation of astrocytes derived from induced pluripotent stem cells (iPSCs) is of great significance in neuroscience research, and it is crucial to obtain both cellular morphology and biomolecular information non-destructively in situ, which is still complicated by the traditional optical microscopy and biochemical methods such as immunofluorescence and western blot. In this study, we combined digital holographic microscopy (DHM) and surface-enhanced Raman scattering (SERS) to investigate the activation c… Show more
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