Über die Wirkung von Hypophysenvorderlappenextrakten auf den Blutkalkspiegel

Hoffmann, Fr.; Anselmino, K. J.

doi:10.1007/bf01799041

Cited by 14 publications

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“…89 Recently Ham90 reported changes supposedly characteristic of the parathyrotropic hormone in the parathyroids of dogs treated with pituitary extract.…”

Section: The Parathyrotropic Hormonementioning

confidence: 99%

“…In the rat Anselmino and co-workers 94 claimed to have obtained particularly obvious parathyroid enlargement accompanied by hypercalcemia following treatment with their extract of the parathyrotropic factor, and Hoffmann and Anselmino 89 As in all fields of medicine, the advent of sulfanilamide and its derivatives has been a welcome addition to the armamentarium of the urologist. Almost a decade ago chemotherapy in urology made its first real step forward with the use of the ketogenic diet in the treatment of infection of the urinary tract.…”

Section: The Parathyrotropic Hormonementioning

confidence: 99%

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Corticotropic (Adrenotropic), Thyrotropic and Parathyrotropic Factors

Collip¹

1940

JAMA

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seven cases at autopsy and one clinical case. All but two of the patients were under 1 year of age and the oldest was 3% years. Robinson3 in 1927 reported an autopsy specimen from a man aged 19. Dodson and Lorraine4 observed during life a youth aged 19 in whom hypertrophy of the verumontanum was a cause of urinary obstruction and retention, and a good result followed fulguration of the verumontanum. Baldridge5 reported another case in which cure followed fulguration of the verumontanum in an 11 year old patient. Somerforde in 1936 again observed this lesion at autopsy in a child aged 11 years. The latest report is that of Grant7 in 1938 in which he mentions a boy aged 13 years in whom hypertrophy of the verumontanum was noted during life and relief of obstruction followed fulguration of the verumontanum. COMMENT There is no satisfactory explanation for congenital hypertrophy of the verumontanum. The greatly enlarged verumontanum probably acts as a ball valve just in front of the external sphincter in the same way that median lobe prostatic hypertrophy acts in the region of the internal sphincter. Mechanical obstruction to the flow of urine is produced.The pathologic changes in the urinary tract and the symptoms are similar to those resulting from enlargement of the prostate gland or any other type of infravesical obstruction. There is dilatation of the posterior urethra behind the verumontanum. During the earlier stages of obstruction there are hypertrophy of the bladder with trabeculation, hypertrophy of the trigon, perhaps diverticulum formation and inflammation, dependent on the degree of associated infection. Later, when decompensation of the bladder occurs, there follows dilatation of the bladder, which together with inflammatory changes in the bladder wall result in incompetence of the ureterovesical valve mechanism. Ureteral and pelvic dilatation occur, and in the most advanced cases the renal parenchyma becomes a thin shell. This compression atrophy, accompanied in many cases by infection, eventually reduces renal function to a point at which it will no longer support life.The early symptoms are those of urinary obstruction. Later there are renal insufficiency and uremia. Frequency of urination is the most common symptom. With associated infection, frequency often becomes very marked with almost constant dribbling. Enuresis may be the most prominent symptom. One may observe in older children considerable straining, hesitancy and difficulty in voiding. When bladder distention occurs it may be observed as a mass in the lower part of the abdomen. Recurrent episodes of fever, often diagnosed as pyelitis, are common. As renal damage advances, the symptoms of renal insufficiency appear. There may be failure to gain, or even loss of weight. Loss of appetite and gastrointestinal upsets are common, as well as headaches and lassitude. With a lowered renal reserve these patients are more susceptible to intercurrent infections and often die of them. They may lapse into uremic coma. The true cause of the trouble ma...

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“…89 Recently Ham90 reported changes supposedly characteristic of the parathyrotropic hormone in the parathyroids of dogs treated with pituitary extract.…”

Section: The Parathyrotropic Hormonementioning

confidence: 99%

Section: The Parathyrotropic Hormonementioning

confidence: 99%

Corticotropic (Adrenotropic), Thyrotropic and Parathyrotropic Factors

Collip¹

1940

JAMA

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Diabetogenic, Thyrotropic, Adrenotropic and Parathyrotropic Factors of the Pituitary

Collip¹

1935

JAMA

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A study of the parathyroid glands of the normal and hypophysectomized monkey (Macaca mulatta)

Baker

1942

Anat. Rec.

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ONE TEXT FIGURE AND TWO P L A T~S (FIFTEEN FIGURES)Studies on the effect of hypophysectomy on the parathyroids have not been reported in monkeys or other primates, and even the normal structure of the parathyroids in these higher animals has not been described except for brief papers by Cowdry and Scott ( '36) on the monkey and Arndt ( '23) on the chimpanzee. Observations on these glands in monkeys are of interest not only because of the close phylogenetic relationship of monkeys to man, but also because the parathyroids (of at least M. mulatta) contain oxyphils, a cell type which has been found to be plentiful in the human except in early life. These glands in M. mulatta thus are structurally more similar to those of man than are the parathyroids of inost other laboratory animals 2.Not only because of this characteristic but also because there is no agreement on the effects of hypophysectomy on the parathyroids, it seemed that it might be of value to undertake a study of the rather plentiful material available from the normal and experimental animals in this laboratory.'Aided by a grant, administered by Dr. P. E. Smith, from the Rockefeller Foundation.' Levine ( '28) stated that oxyphils are present in the parathyroids of the cow and steer, and Houssay and Sammartino ( '34) found an occasional oxyphil in the parathyroids of three operated but in no normal dogs. Arndt ('23) found a few oxyphils in the parathyroids of one of three chimpanzees. 47

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Über die Wirkung von Hypophysenvorderlappenextrakten auf den Blutkalkspiegel

Cited by 14 publications

References 0 publications

Corticotropic (Adrenotropic), Thyrotropic and Parathyrotropic Factors

Corticotropic (Adrenotropic), Thyrotropic and Parathyrotropic Factors

Diabetogenic, Thyrotropic, Adrenotropic and Parathyrotropic Factors of the Pituitary

A study of the parathyroid glands of the normal and hypophysectomized monkey (Macaca mulatta)

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