Über die Wirkung von 5-Hydroxytryptophan auf den Magendarmtrakt des Menschen

Recent Research in the Field of 5-Hydroxytryptamine and Related Indolealkylamines

“…5-HTP infused intravenously for 10 minutes at a rate of 10-80 p,g/kg/min produces a more intense and sustained reduction of gastric secretion [1082].…”

“…The effect of intravenous 5-HTP (threshold dose 100-200 flg/kg given over a period of 5 minutes) differs from that of 5-HT in that the aminoacid provides a more sustained stimulation of the small intestine [558J with inhibition of the stomach and colon and no tachyphylaxis [1082]. The stimulant effect of 5-HTP is inhibited not only by BOL (2 mg, orally) but also by atropine (1 mg, i.v.)…”

“…At variance with CALl and CORDOVA who have found that intravenous 5-HT (2 mg) produces in man a stimulant action on gastric secretion [209,206], which is inhibited by antihistaminic drugs [209], all other research workers [559,558,993,1076,1082,920] have observed that 5-HTP and 5-HT inhibit volume and acidity of both spontaneous and histamine-induced gastric secretion, while at the same time increasing production of mucous [993,920].…”