Clinical aspects of cerebral and extracerebral 5-hydroxytryptamine

Stacey, R. S.

doi:10.1007/978-3-642-85467-5_14

Cited by 7 publications

(3 citation statements)

References 234 publications

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“…All 5-HT in blood is contained in the platelets (Stacey, 1966), therefore we investigated the effects of platelet extracts on the aortic strip. Figure 8 shows that platelets cause contractions of the aortic strip which are not due to 5-HT.…”

Section: Discussionmentioning

confidence: 99%

Aetiology of cerebral arterial spasm following subarachnoid haemorrhage: evidence against a major involvement of 5‐hydroxy‐ tryptamine in the production of acute spasm.

Boullin¹,

Boulay²,

Rogers³

1978

Brit J Clinical Pharma

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Section: Discussionmentioning

confidence: 99%

Aetiology of cerebral arterial spasm following subarachnoid haemorrhage: evidence against a major involvement of 5‐hydroxy‐ tryptamine in the production of acute spasm.

Boullin¹,

Boulay²,

Rogers³

1978

Brit J Clinical Pharma

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“…Aus diesem Grund und wegen der zahlreiehen weiteren M6glichkeiten der Beein~lussung des Tryptophan-Stoffwechsels dareh exogene [19--22] und endogene [19,8,23] Faktoren, stellen wir die Spezifit~t und damit die diagnostische Wertigkeit einer veri~nderten 5-HIAA-Ausseheidung als bioehemisehes Kriterium einer Bleiexposition in Frage. Abdominelle Koliken, nearologische Ver~nderungen und StSrungen der Vasomotorik [24] wfirden zu einem ~berproduktionsmechanismus yon Serotouin passen. Als Angriffspunkt betrachten wir dabei die h~mhaltige TP, deren Induktion und Aktivitiit durch StSrungen im Porphyrinstoffwechsel herabgesetzt wird.…”

Section: Sehlubfolgerungenunclassified

�ber die Beeinflussung des Tryptophan-Stoffwechsels durch Blei

Schiele¹,

Schaller²,

Valentin³

1974

Klin Wochenschr

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“…The concentration of 5-HT in umbilical arterial blood at term has been estimated to be 43 ng/ml (Stacey, 1966), suggesting that 5-HT could be a potential vasoconstrictor of the HUA, even if only 1 % of the amine were free. 5-HT-induced constriction of the HUA is mediated via two subtypes of 5-HT receptor which we have classified as 5-HT2 and '5-HT1-like' (McGrath, MacLennan & Stuart-Smith, 1985;.…”

mentioning

confidence: 99%

Comparison of the Effects of Oxygen, 5‐hydroxytryptamine, Bradykinin and Adrenaline in Isolated Human Umbilical Artery Smooth Muscle

McGrath

MacLennan²,

Whittle

1988

Exp Physiol

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SUMMARYThe actions of 5-HT, bradykinin and adrenaline on the isolated human umbilical artery (HUA) were examined in paired isometric and isotonic preparations and in paired isometric and perfused preparations at both low ( 20 mmHg) and high (-120 mmHg) oxygen tensions. The response to each agonist was potentiated by the higher oxygen tension in all test systems. The relative potency of the three agonists studied was similar using each of the experimental techniques. The contractions to stepped increments in oxygen tension were compared in isometric and isotonic preparations. The thresholds were found to be 20 and 28 mmHg respectively. The maximum contraction occurred at 234 and 199 mmHg respectively. In the perfused (constant flow rate) preparations, oxygen did not evoke any increase in perfusion pressure unless the vessel was held under longitudinal tension, in which case the pressor responses were similarly concentration dependent as for isometric and isotonic preparations. Responses to 5-HT, bradykinin and adrenaline in the perfused preparation were similar with or without application of longitudinal tension. It is concluded that oxygen may contract only the longitudinal muscle whereas 5-HT, bradykinin and adrenaline act on both longitudinal and circular muscle. The possible roles which these agonists may play in the regulation of umbilical blood flow are discussed.

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Clinical aspects of cerebral and extracerebral 5-hydroxytryptamine

Cited by 7 publications

References 234 publications

Aetiology of cerebral arterial spasm following subarachnoid haemorrhage: evidence against a major involvement of 5‐hydroxy‐ tryptamine in the production of acute spasm.

Aetiology of cerebral arterial spasm following subarachnoid haemorrhage: evidence against a major involvement of 5‐hydroxy‐ tryptamine in the production of acute spasm.

�ber die Beeinflussung des Tryptophan-Stoffwechsels durch Blei

Comparison of the Effects of Oxygen, 5‐hydroxytryptamine, Bradykinin and Adrenaline in Isolated Human Umbilical Artery Smooth Muscle

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