Über die Wirkung des Baldrians und eine Methode der Wertbestimmung

Kochmann, M.; Kunz, H.

doi:10.1007/bf01960462

Cited by 11 publications

(1 citation statement)

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“…Caffeine, on the other hand, acts on the adenosine receptors as an antagonist and induces CNS arousal. This arousal, in the earlier literature called caffeine excitation and assessed as motor activity, could be effectively blocked by valerian extracts in both animals [11], [12] and humans [13]. The excitation evoked by 0.1 g caffeine in humans was most pronounced 1 to 3 hours after oral administration and could almost be completely prevented by simultaneous administration of 3 tablets of valerian, which corresponds to 100 valerian mice units [12].…”

Section: Introductionmentioning

confidence: 94%

The Fixed Combination of Valerian and Hops (Ze91019) acts via a Central Adenosine Mechanism

Schellenberg¹,

Sauer²,

Abourashed

et al. 2004

Planta med

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The aim of the study was to demonstrate competition between caffeine and a fixed valerian/hop extract combination (Ze91019) by the central adenosine mechanism. EEG was used to describe the action of caffeine on the central nervous system after oral administration (200 mg) in healthy volunteers. In addition to caffeine, the volunteers (16 in each group) received either placebo or verum (2 and 6 tablets containing the valerian/hop extract). The EEG responses were recorded every 30 min thereafter. The verum medication was capable of reducing (2 tablets) or inhibiting (6 tablets) the arousal induced by caffeine. This pharmacodynamic action was observed 60 minutes after oral administration, indicating not only competition between the antagonist caffeine and the partial agonist, i. e., the valerian/hop extract but also bio-availability of the compound(s) responsible for the agonistic action. In conclusion, the valerian/hop extract acts via a central adenosine mechanism which is possibly the reason for its sleep-inducing and -maintaining activity.

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Section: Introductionmentioning

confidence: 94%