Über die Oxydation von Ascorbinsäure durch salpetrige Säure Teil VI: Übersicht und Diskussion der Ergebnisse. 18. Mitteilung über Reduktone und 1,2,3‐Tricarbonylverbindungen

Abstract

The oxidation of ascorbic acid and phenylhydroxytetronic acid by nitrous acid at various values of pH follows four distinct rate laws, discussed in parts II, III and IV of the present series of papers.

Protective Effect of Ascorbic Acid on Hepatotoxicity Caused by Sodium Nitrite Plus Aminopyrine

“…Recently, Mirvisch et al (8) demonstrated that ascorbate blocks the formation of nitrosamines in vitro by competing for available nitrite. The reaction between ascorbate and nitrous acid has been described by Dahn et al (9). A similar competition, which would prevent the formation of dimethylnitrosamine from sodium nitrite and aminopyrine, may occur in rat stomach.…”

Methylation of DNA by incubation with methylamine and nitrite

“…The reaction was started by injection of potassium nitrite dissolved in the same buffer. The solution was kept at 37°C, slowly stirred with a magnetic stirrer, and the reaction was stopped after 30 min by addition of sodium ascorbate in 2-fold molar excess of the nitrite concentration (9). Immediately before stopping the reaction, a 1 ml sample of the gas phase above the reaction mixture was taken out with a syringe and injected into a 2 ml serum vial prefilled with 1 g methanol and closed with a septum.…”

Naturally Occurring Anticarcinogenic Substances in Foodstuffs

“…Ascorbic acid was the first naturally occurring substance found to effectively block the formation of N-nitroso compounds (20,(72)(73)(74)(75). Ascorbic acid and, more so, the ascorbate anion (72) reduce N203 to nitric oxide, NO, thus decreasing the concentration of N203 available for nitrosation of amines and amides.…”