Über die gestaltende Wechselwirkung zwischen dem Epithel und dem Mesenchym, zugleich ein Beitrag zur Histogenese der sogenannten „Gallengangswucherungen”

Doljanski, L.; Roulet, Frédéric

doi:10.1007/bf01891531

Cited by 47 publications

(5 citation statements)

References 13 publications

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“…4). In the classical experimental evidence of Doljanski and Roulet (1934), adult hepatocytes are able to differentiate into biliary epithelial cells in coculture with connective tissue, which lends support to this idea. Portal veins and hepatic veins, which are other large veins in the liver, share a common origin from omphalomesenteric veins.…”

Section: Mechanisms Of Bile Duct Differentiationsupporting

confidence: 64%

Development and differentiation of bile ducts in the mammalian liver

Shiojiri

1997

Microsc. Res. Tech.

131

101

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Section: Mechanisms Of Bile Duct Differentiationsupporting

confidence: 64%

Development and differentiation of bile ducts in the mammalian liver

Shiojiri

1997

Microsc. Res. Tech.

131

101

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“…The factors determining the developmental fate of the bipotential hepatoblasts remain incompletely known. There is evidence that components of the portal mesenchyme are crucial for inducing the phenotypic shift into bile duct‐type cells in the layers of the ductal plate (Doljanski and Roulet,1934).…”

Section: Development Of Intrahepatic Bile Ductsmentioning

confidence: 99%

Embryology of Extra‐ and Intrahepatic Bile Ducts, the Ductal plate

Roskams

Desmet

2008

The Anatomical Record

188

133

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In the human embryo, the first anlage of the bile ducts and the liver is the hepatic diverticulum or liver bud. For up to 8 weeks of gestation, the extrahepatic biliary tree develops through lengthening of the caudal part of the hepatic diverticulum. This structure is patent from the beginning and remains patent and in continuity with the developing liver at all stages. The hepatic duct (ductus hepaticus) develops from the cranial part (pars hepatica) of the hepatic diverticulum. The distal portions of the right and left hepatic ducts develop from the extrahepatic ducts and are clearly defined tubular structures by 12 weeks of gestation. The proximal portions of the main hilar ducts derive from the first intrahepatic ductal plates. The extrahepatic bile ducts and the developing intrahepatic biliary tree maintain luminal continuity from the very start of organogenesis throughout further development, contradicting a previous study in the mouse suggesting that the extrahepatic bile duct system develops independently from the intrahepatic biliary tree and that the systems are initially discontinuous but join up later. The normal development of intrahepatic bile ducts requires finely timed and precisely tuned epithelialmesenchymal interactions, which proceed from the hilum of the liver toward its periphery along the branches of the developing portal vein. Lack of remodeling of the ductal plate results in the persistence of an excess of embryonic bile duct structures remaining in their primitive ductal plate configuration. This abnormality has been termed the ductal plate malformation.

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“…1,2 Periportal connective tissue induces the subjacent hepatoblasts to differentiate into biliary epithelial cells, 3 and during their differentiation, laminin, peanut agglutinin (PNA)-binding sites and bile duct-type cytokeratins are expressed. 4 -9 Recent studies have shown that Jagged1 and Notch2 expressed in periportal cells are involved in that differentiation.…”

mentioning

confidence: 99%