Über die Bildung von γ‐ Piperidonderivaten aus Azetessigester, aromatischen Aldehyden und Aminen, eine Modifikation der Hantzsch schen Pyridinsynthese

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“…(Scheme 7b). Treatment of ethyl acetoacetate with benzaldehyde and aniline in absolute ethanol in presence of malonic acid gave ethyl1,2,6-triphenyl-4-oxo-piperidine-3-carboxylate 18,35 . Hydrolysis of the ester with 10% HCl in acetone gave 1,2,6-triphenylpiperidine-4-one.…”

A robust synthesis and characterization of superparamagnetic CoFe2O4 nanoparticles as an efficient and reusable catalyst for green synthesis of some heterocyclic rings

“…A few of them are also potent inhibitors for many biological systems . Boehm and Stoker in 1943 reported the first multicomponent reaction (MCR) between an amine, aldehyde and 1,3‐dicarbonyl to synthesize functionalized piperidines . Apart from some Lewis and Bronsted acid catalysts, a few organocatalysts which include wet picric acid, p ‐toluenesulfonic acid, bromodimethylsulfonium bromide, tetrabutylammonium tribromide, l ‐proline nitrate and thiourea oxide have been reported for this MCR.…”

“…[22] Boehm and Stoker in 1943 reported the first multicomponent reaction (MCR) between an amine, aldehyde and 1,3-dicarbonyl to synthesize functionalized piperidines. [23] Apart from some Lewis and Bronsted acid catalysts, [24] a few organocatalysts which include wet picric acid, [25] p-toluenesulfonic acid, [26] bromodimethylsulfonium bromide, [27] tetrabutylammonium tribromide, [28] L-proline nitrate [29] and thiourea oxide [30] have been reported for this MCR. Mishra and co-workers have reported L-proline and trifluoroacetic acid as a dual catalytic system for this MCR.…”