Über die Acylierung von N,N′‐Polymethylenharnstoffen

Dantchev, D.; Christova, K.; Mutaftschieva, V.; Daleva, D.

doi:10.1002/ardp.19743070905

Cited by 4 publications

(1 citation statement)

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“…1 Derivatives of cyclic urea are of special interest as building blocks in synthetic organic chemistry, 2-5 unique organic ligands, 6-9 solvents and co solvents. 10, 11 These compounds exhibit considerable anti bacterial, 12,13 sedative hypnotic, 14, 15 antitumor, 16, 17 and antiviral 18 activity. It should be noted that derivatives of cyclic ureas are active inhibitors of enzymes:  secretase (BASE1) 19, 20 and HIV 1 protease.…”

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Synthesis and structure of potentially biologically active N-(silylmethyl)tetrahydropyrimidin-2-ones

Lazareva

Lazarev

2014

Russ Chem Bull

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A transsilylation of 1,3 bis(trimethylsilyl)tetrahydropyrimidin 2 one with (chloromethyl) chlorosilanes ClCH 2 SiMe n Cl 3-n (n = 0, 2) gave the corresponding 1,3 bis[(chlorosilyl) methyl]tetrahydropyrimidin 2 ones. New Si containing tetrahydropyrimidin 2 ones were syn thesized by the exchange reactions at the Si-Cl and Si-N bonds of these compounds. The structures of all the synthesized compounds were confirmed by multinuclear NMR spectro scopy. Virtual screening using the PASS program showed that these compounds can exhibit certain types of biological activity with 40-94% probability.

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confidence: 99%

Synthesis and structure of potentially biologically active N-(silylmethyl)tetrahydropyrimidin-2-ones

Lazareva

Lazarev

2014

Russ Chem Bull

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Structure and Properties of Cyclic Polymethylene Ureas, III. Synthesis and Biological Activity of Some Mannich Bases of Tetrahydro‐2‐(1H)‐Pyrimidinone

Sidzhakova

Danchev

Galabov

et al. 1982

Archiv der Pharmazie

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Some N-mono-2a-e and N,N'-bis(aminomethy1) derivatives 3a-b of tetrahydro-2-( 1H)-pynmidinone l a and tetrahydro-2( 1H)-pyrimidinethione l e are obtained by the Munnich reaction of l a or l e with formaldehyde and secondary amines. The compounds show a marked antiviral activity. Struktur und Eigenschaften cydicher Polymethylen-Harnstoffe, 3. Mitt.: Synthese und biologische Aktivitat von einigen Tetrahydro-2(1H)-Pyrimidinon-Mannich-Basen Es wurden N-mono-2a-e und N,N'-bis-aminomethyl-Derivate 3a-b von Tetrahydro-2-( 1H)-pyrimidinon la und Tetrahydro-2(1H)-pyrimidinthion l e durch Munnich Reaktion von l a oder l e mit 0365-6233/82/0M)&00509 $ 02.50/0 0 Verlag Chemie GmbH. Weinheim 1982

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