Synthesis and structure of potentially biologically active N-(silylmethyl)tetrahydropyrimidin-2-ones

Abstract

A transsilylation of 1,3 bis(trimethylsilyl)tetrahydropyrimidin 2 one with (chloromethyl) chlorosilanes ClCH 2 SiMe n Cl 3-n (n = 0, 2) gave the corresponding 1,3 bis[(chlorosilyl) methyl]tetrahydropyrimidin 2 ones. New Si containing tetrahydropyrimidin 2 ones were syn thesized by the exchange reactions at the Si-Cl and Si-N bonds of these compounds. The structures of all the synthesized compounds were confirmed by multinuclear NMR spectro scopy. Virtual screening using the PASS program showed that these compounds can exhibit certain types of biological activity with 40-94% probability.