Über den Ursprung des Sympathicus beim Hühnchen

Müller, E.; Ingvar, Sven

doi:10.1007/bf02248083

Cited by 13 publications

(1 citation statement)

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“…The neural crest is a transient population of cells that migrates from the dorsal neural tube during development and generates the majority of the neurons and glia of the peripheral nervous system. The thoracolumbar region of the trunk neural crest gives rise to cells of the sensory dorsal root ganglion (Müller and Ingvar, 1923;Pannese, 1974) and the autonomic sympathetic neurons (Le Douarin, 1980). The dorsal root ganglion itself shows further cellular diversity, with many different types of sensory neurons that can be subdivided into different subclasses regarding function, size and receptor expression (Snider, 1994).…”

Section: Introductionmentioning

confidence: 99%

The boundary cap: a source of neural crest stem cells that generate multiple sensory neuron subtypes

et al. 2005

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The boundary cap (BC) is a transient neural crest-derived group of cells located at the dorsal root entry zone (DREZ) that have been shown to differentiate into sensory neurons and glia in vivo. We find that when placed in culture, BC cells self-renew, show multipotency in clonal cultures and express neural crest stem cell (NCSCs) markers. Unlike sciatic nerve NCSCs,the BC-NCSC (bNCSCs) generates sensory neurons upon differentiation. The bNCSCs constitute a common source of cells for functionally diverse types of neurons, as a single bNCSC can give rise to several types of nociceptive and thermoreceptive sensory neurons. Our data suggests that BC cells comprise a source of multipotent sensory specified stem cells that persist throughout embryogenesis.

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