Observations upon the migration of neural crest cells, and upon the development of the spinal ganglia and vertebral arches in Amblystoma

Detwiler, S. R.

doi:10.1002/aja.1000610104

Cited by 108 publications

(23 citation statements)

References 28 publications

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“…In fish and amphibia, however, there have been a number of studies proposing that larval fin mesenchyme cells derive from trunk ectomesenchymal neural crest (reviewed by Hall and Hörstadius, 1988;Le Douarin, 1982;Le Douarin and Kalcheim, 1999). This was first suggested in the 1930s based on xenotransplantation and cell staining experiments (Detwiler, 1937;Holtfreter, 1935;Raven, 1936;Raven, 1932). This cell type was assumed to contribute to the connective tissue of the fins and thus to represent an ectomesenchyme derivative.…”

Section: Introductionsupporting

confidence: 42%

An exclusively mesodermal origin of fin mesenchyme demonstrates that zebrafish trunk neural crest does not generate ectomesenchyme

et al. 2013

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SUMMARYThe neural crest is a multipotent stem cell population that arises from the dorsal aspect of the neural tube and generates both nonectomesenchymal (melanocytes, peripheral neurons and glia) and ectomesenchymal (skeletogenic, odontogenic, cartilaginous and connective tissue) derivatives. In amniotes, only cranial neural crest generates both classes, with trunk neural crest restricted to nonectomesenchyme. By contrast, it has been suggested that anamniotes might generate derivatives of both classes at all axial levels, with trunk neural crest generating fin osteoblasts, scale mineral-forming cells and connective tissue cells; however, this has not been fully tested. The cause and evolutionary significance of this cranial/trunk dichotomy, and its absence in anamniotes, are debated. Recent experiments have disputed the contribution of fish trunk neural crest to fin osteoblasts and scale mineral-forming cells. This prompted us to test the contribution of anamniote trunk neural crest to fin connective tissue cells. Using genetics-based lineage tracing in zebrafish, we find that these fin mesenchyme cells derive entirely from the mesoderm and that neural crest makes no contribution. Furthermore, contrary to previous suggestions, larval fin mesenchyme cells do not generate the skeletogenic cells of the adult fin, but persist to form fibroblasts associated with adult fin rays. Our data demonstrate that zebrafish trunk neural crest does not generate ectomesenchymal derivatives and challenge long-held ideas about trunk neural crest fate. These findings have important implications for the ontogeny and evolution of the neural crest.

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Section: Introductionsupporting

confidence: 42%

An exclusively mesodermal origin of fin mesenchyme demonstrates that zebrafish trunk neural crest does not generate ectomesenchyme

et al. 2013

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“…These cells were localized in a dorsolateral position with respect to the paired descending aorta and represent the primordia of the thoracic ganglia. At the same time, no labeled cells were detected in the abdominal region, following the well known rostral-caudal gradient of differentiation (26).…”

Section: Resultsmentioning

confidence: 50%

Appearance of catecholamine-synthesizing enzymes during development of rat sympathetic nervous system: Possible role of tissue environment

Teitelman

Baker

Joh

et al. 1979

Proc. Natl. Acad. Sci. U.S.A.

138

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“…The migrating pathway of neural crest cells (JOHNSTON, 1966;NODEN, 1975;BRONNER-FRASER and CoHEN, 1980a), the relationships between the migrating neural crest cells and their surrounding tissues (LE DOUARIN and TEILLET, 1974;PRATT et al, 1975;WESTON et al, 1977;TAKAHASHI and YAMADORI, 1979;TOSNEY, 1978TOSNEY, , 1982 and the differentiation of neural crest cells (RAVEN, 1936;LE DOUARIN and TEILLET, 1973) have been studied. There has been some research on the developmental process from the primordium of the neural crest in the neural fold to the migrating neural crest cells (DETWILER, 1937;SCHROEDER, 1970;LAMERS et al, 1981;ROSENQUIST, 1981). The relationships between the morphogenesis of the neural crest and the migration of neural crest cells have not been fully clarified.…”

Section: Discussionsupporting

confidence: 41%

Morphogenetic studies on the neural crest of hynobius larvae using vital staining and India ink labeling methods.

Hirano

Shirai

1984

Arch. Histol. Jap., Arch. Histol. Jpn

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Observations upon the migration of neural crest cells, and upon the development of the spinal ganglia and vertebral arches in Amblystoma

Cited by 108 publications

References 28 publications

An exclusively mesodermal origin of fin mesenchyme demonstrates that zebrafish trunk neural crest does not generate ectomesenchyme

An exclusively mesodermal origin of fin mesenchyme demonstrates that zebrafish trunk neural crest does not generate ectomesenchyme

Appearance of catecholamine-synthesizing enzymes during development of rat sympathetic nervous system: Possible role of tissue environment

Morphogenetic studies on the neural crest of hynobius larvae using vital staining and India ink labeling methods.

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