Tzanck smear utilized in the diagnosis of Hailey-Hailey disease mimicking genital herpes

Riahi, Ryan R; Yamazaki, Masahito; Kelly, Brent

doi:10.1111/j.1365-4632.2011.05423.x

Cited by 7 publications

(2 citation statements)

References 7 publications

(22 reference statements)

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“…Of note, true herpesvirus infections may superimpose on acantholytic dermatoses such as TAD, Darier disease or pemphigus . Furthermore, pseudoherpetic features have been identified in other acantholytic dermatoses including pemphigus vulgaris, Darier disease and Hailey‐Hailey disease . The morphologic clues described in this series, in conjunction with appropriate immunohistochemistry, are helpful in identifying an unusual variant of TAD, in itself a very common clinical and histologic diagnosis.…”

Section: Discussionmentioning

confidence: 75%

Pseudoherpetic transient acantholytic dermatosis (Grover disease): case series and review of the literature

Motaparthi

2017

J Cutan Pathol

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A total of 3 cases of pseudoherpetic transient acantholytic dermatosis (Grover disease) are presented, followed by a brief review of prior reports. All 3 patients were above the age of 60 and presented with a pruritic eruption composed of papules with or without vesicles distributed on the trunk. For all 3 patients, the clinical differential diagnosis included drug eruption but did not include Grover disease; in 1 patient, the clinical impression included herpesvirus infection. Similar histologic and immunohistochemical findings were demonstrated in all 3 cases. Intraepidermal vesicles with acantholysis, multinucleation and hypereosinophilic keratinocytes mimicking necrosis raised the possibility of herpesvirus infection. However, the focality of the process at scanning magnification, absence of true cytopathic effect despite multinucleation, and identification of dyskeratosis rather than true necrosis all permitted for morphologic distinction as pseudoherpetic change. Immunohistochemistry, negative for herpes simplex virus and varicella zoster virus antigens, also distinguished pseudoherpetic change in these patients from a true herpesvirus infection. This series highlights an uncommon histologic variant of a common disorder and describes morphologic and immunohistochemical findings to facilitate its distinction from true herpesvirus infection.

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Section: Discussionmentioning

confidence: 75%

Pseudoherpetic transient acantholytic dermatosis (Grover disease): case series and review of the literature

Motaparthi

2017

J Cutan Pathol

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“…Although herpes simplex infection can mimic the vesicular lesions of Hailey-Hailey disease, Tzanck smear is useful to differentiate the diseases. 3 …”

mentioning

confidence: 99%

Erythematous, vesicular, and circinate lesions in a 78-year-old female – benign familial pemphigus

Plaza

Sancho

Millet

et al. 2017

An. Bras. Dermatol.

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Inherited Acantholytic Disorders

Zamiri

Munro

2016

Rook's Textbook of Dermatology, Ninth Edition

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Darier disease (DD) and Hailey–Hailey disease (HHD) are autosomal dominant disorders characterized by epidermal acantholysis. They have a similar molecular pathogenesis, with mutations in the intracellular calcium pumps of the endoplasmic reticulum (SERCA2) and Golgi (SPCA1), respectively. DD presents with persistent, hyperkeratotic papules in a seborrhoeic distribution, associated with nail changes and palmar pitting. HHD presents with painful, mainly flexural, erosions. In both, secondary infection is common and hypertrophic flexural disease can be disabling. Histologically, both are characterized by loss of epidermal intercellular adhesion (acantholysis). In DD, acantholysis is predominantly suprabasal and there is overlying dyskeratosis. In HHD, acantholysis is more diffuse. First line topical treatment is with emollients, antimicrobials and corticosteroids. Oral antibiotics are often necessary for exacerbations; other systemic options include retinoids and ciclosporin. Physical measures such as laser resurfacing, photodynamic therapy, botulinum toxin and surgical interventions can be considered in refractory cases.

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Tzanck smear utilized in the diagnosis of Hailey-Hailey disease mimicking genital herpes

Cited by 7 publications

References 7 publications

Pseudoherpetic transient acantholytic dermatosis (Grover disease): case series and review of the literature

Pseudoherpetic transient acantholytic dermatosis (Grover disease): case series and review of the literature

Erythematous, vesicular, and circinate lesions in a 78-year-old female – benign familial pemphigus

Inherited Acantholytic Disorders

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