Erythematous, vesicular, and circinate lesions in a 78-year-old female – benign familial pemphigus

Plaza, Ana Iglesias; Sancho, Maribel Iglesias; Millet, Pablo Umbert; Muñoz, N. Pérez

doi:10.1590/abd1806-4841.20176711

Cited by 7 publications

(4 citation statements)

References 5 publications

(5 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Other individual case reports have been published, using high doses of vitamin D3 (8000 IU per day) [119] as well as the anticholinergics glycopyrrolate [120] and oxybutynin [121] for successful reduction of sweating.…”

Section: Novel Therapiesmentioning

confidence: 99%

Darier and Hailey‐Hailey disease: update 2021

Rogner

Lammer

Zink

et al. 2021

J Deutsche Derma Gesell

View full text Add to dashboard Cite

Summary The autosomal‐dominant genodermatoses Darier disease and Hailey‐Hailey disease present special challenges to dermatologists. Despite their similar pathogenesis featuring impaired adhesion of suprabasal keratinocytes as a result of defective ATPases in epidermal calcium channels, the two diseases differ considerably in clinical presentation and therapeutic options. Darier disease is characterized by reddish brown, keratotic papules in seborrheic and intertriginous areas, which may coalesce into extensive lesions. Individuals affected with Hailey‐Hailey disease primarily develop intertriginous papulovesicles and small blisters, which often evolve into erythematous plaques with erosions and painful fissures. Quality of life is significantly reduced because of complaints (itch, burning sensation, pain), body malodor and chronicity. Therapeutic options remain limited. Antiseptics and intermittent topical corticosteroids are a cornerstone of therapy, and systemic anti‐infective treatment is often required in cases of superinfection. Ablative surgical interventions such as dermabrasion and CO2 laser surgery can lead to long‐term remissions in intertriginous Hailey‐Hailey disease, while temporary relief may also be achieved by intralesional injections of botulinum toxin. Of the systemic medications available for Darier disease, acitretin, which is approved for this purpose, has the best supporting evidence. The efficacy of immunosuppressants and immune modulators is inconsistent. Low‐dose naltrexone produces more satisfactory results in Hailey‐Hailey than Darier disease. The present CME article summarizes current knowledge of the two dermatoses, taking recent developments into account.

show abstract

Section: Novel Therapiesmentioning

confidence: 99%

Darier and Hailey‐Hailey disease: update 2021

Rogner

Lammer

Zink

et al. 2021

J Deutsche Derma Gesell

View full text Add to dashboard Cite

show abstract

“… Note: Data taken from several studies. 2 , 7 , 9 , 10 , 28 , 29 , 31 , 47 , 49 – 51 , 58 , 62 – 64 , 67 , 69 , 70 , 72 – 77 , 84 , 96 – 103 Abbreviations: HPV, human papillomavirus; EIB, Erosio interdigitalis blastomycetica …”

Section: Figurementioning

confidence: 99%

Recurrent candidal intertrigo: challenges and solutions

Metin

Dilek

Bilgili

2018

CCID

View full text Add to dashboard Cite

Intertrigo is a common inflammatory dermatosis of opposing skin surfaces that can be caused by a variety of infectious agents, most notably candida, under the effect of mechanical and environmental factors. Symptoms such as pain and itching significantly decrease quality of life, leading to high morbidity. A multitude of predisposing factors, particularly obesity, diabetes mellitus, and immunosuppressive conditions facilitate both the occurrence and recurrence of the disease. The diagnosis of candidal intertrigo is usually based on clinical appearance. However, a range of laboratory studies from simple tests to advanced methods can be carried out to confirm the diagnosis. Such tests are especially useful in treatment-resistant or recurrent cases for establishing a differential diagnosis. The first and key step of management is identification and correction of predisposing factors. Patients should be encouraged to lose weight, followed up properly after endocrinologic treatment and intestinal colonization or periorificial infections should be medically managed, especially in recurrent and resistant cases. Medical treatment of candidal intertrigo usually requires topical administration of nystatin and azole group antifungals. In this context, it is also possible to use magistral remedies safely and effectively. In case of predisposing immunosuppressive conditions or generalized infections, novel systemic agents with higher potency may be required.

show abstract

“…Rarely, mucosal involvement was observed including conjunctival, oral, esophageal, and vaginal mucosa ( Burge, 1992 ; Oğuz et al, 1997 ; Fresco et al, 2020 ). There are some clinical variants in this disease, such as generalized, segmental, vesiculobullous, condylomatous, circinate or annular, lichenoid, and psoriasiform HHD ( Hwang et al, 2003 ; Vilmer and Dehen, 2004 ; Ghosh et al, 2017 ; Plaza et al, 2017 ; Ni et al, 2018 ; Leducq et al, 2020 ; Ting et al, 2021 ). HHD was concomitant with bullous pemphigoid, eczema herpeticum, and human papillomavirus infection in a few cases ( Chan et al, 2007 ; Shah et al, 2020 ; Li et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Case Report: A Case of Hailey–Hailey Disease Mimicking Condyloma Acuminatum and a Novel Splice-Site Mutation of ATP2C1 Gene

Dai

Wang

et al. 2021

Front. Genet.

View full text Add to dashboard Cite

Hailey–Hailey disease (HHD) is a rare autosomal-dominant blistering disorder characterized by recurrent vesicular and erosive lesions at intertriginous sites. We described a 24-year-old male who presented with multiple bright red verrucous papules in his mons pubis, bilateral groins, scrotum, perineum, and crissum, clinically resembling condyloma acuminatum. The histopathology showed extensive acantholysis with the characteristic appearance of a dilapidated brick-wall. The mutation analysis revealed a novel splice-site mutation in the ATP2C1 gene. The patient was definitely diagnosed with HHD. The antibacterial treatments resulted in a dramatic improvement. Our findings help to broaden the understanding of clinical manifestations of HHD and improve the clinical diagnosis and treatment of this disease.

show abstract

Erythematous, vesicular, and circinate lesions in a 78-year-old female – benign familial pemphigus

Cited by 7 publications

References 5 publications

Darier and Hailey‐Hailey disease: update 2021

Darier and Hailey‐Hailey disease: update 2021

Recurrent candidal intertrigo: challenges and solutions

Case Report: A Case of Hailey–Hailey Disease Mimicking Condyloma Acuminatum and a Novel Splice-Site Mutation of ATP2C1 Gene

Contact Info

Product

Resources

About