Tyrosol as a Neuroprotector: Strong Effects of a “Weak” Antioxidant

Плотников, М. Б.; Плотникова, Т. М.

doi:10.2174/1570159x18666200507082311

Cited by 30 publications

(18 citation statements)

References 142 publications

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“…In an in vitro incubation study with human fecal slurry, cinnamylalcohol, tyrosol, and hydroquinone were identified as the main phenolic metabolites [ 168 ]. Tyrosol is able to penetrate the BBB and has shown potent neuroprotective and neuroregenerative activities in vitro and in animal studies [ 244 ], and hydroquinone has shown protective effects against transient focal cerebral ischemia in rats [ 245 ], indicating the neuroprotective potential of these gut microbial R. rosea metabolites.…”

Section: Resultsmentioning

confidence: 99%

Medicinal Plants and Their Impact on the Gut Microbiome in Mental Health: A Systematic Review

et al. 2022

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Background: Various neurocognitive and mental health-related conditions have been associated with the gut microbiome, implicating a microbiome–gut–brain axis (MGBA). The aim of this systematic review was to identify, categorize, and review clinical evidence supporting medicinal plants for the treatment of mental disorders and studies on their interactions with the gut microbiota. Methods: This review included medicinal plants for which clinical studies on depression, sleeping disorders, anxiety, or cognitive dysfunction as well as scientific evidence of interaction with the gut microbiome were available. The studies were reported using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Results: Eighty-five studies met the inclusion criteria and covered thirty mental health-related medicinal plants with data on interaction with the gut microbiome. Conclusion: Only a few studies have been specifically designed to assess how herbal preparations affect MGBA-related targets or pathways. However, many studies provide hints of a possible interaction with the MGBA, such as an increased abundance of health-beneficial microorganisms, anti-inflammatory effects, or MGBA-related pathway effects by gut microbial metabolites. Data for Panax ginseng, Schisandra chinensis, and Salvia rosmarinus indicate that the interaction of their constituents with the gut microbiota could mediate mental health benefits. Studies specifically assessing the effects on MGBA-related pathways are still required for most medicinal plants.

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Section: Resultsmentioning

confidence: 99%

Medicinal Plants and Their Impact on the Gut Microbiome in Mental Health: A Systematic Review

et al. 2022

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“…Prior to HPLC analysis, polyphenols were extracted from olive oil by US-LLE using methanol and hexane [ 53 ]. HTyr [ 71 , 72 ] and Tyr [ 73 ] are phenolic compounds specific to olive oil, while cinnamic acid [ 74 ], apigenin [ 75 ], and pinoresinol [ 76 ] are widespread and found in a great number of plants. All of these compounds are well known for their bioactive properties, such as antioxidant and antitumor activities, in addition to many others [ 77 , 78 ].…”

Section: Resultsmentioning

confidence: 99%

Extra Virgin Olive Oil Secoiridoids Modulate the Metabolic Activity of Dacarbazine Pre-Treated and Treatment-Naive Melanoma Cells

et al. 2022

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Nowadays, many individuals, whether healthy or diagnosed with disease, tend to expose themselves to various easily accessible natural products in hopes of benefiting their health and well-being. Mediterranean populations have traditionally used olive oil not only in nutrition but also in cosmetics, including skincare. In this study, the phenolic profile—composed of twelve compounds altogether, including the secoiridoids oleocanthal (OCAL) and oleacein (OCEIN)—of extra virgin olive oil (EVOO) from autochthonous cultivars from Croatia was determined using 1H qNMR spectroscopy and HPLC-DAD analysis, and its biological activity was investigated in melanoma cell lines. The EVOO with the highest OCEIN content had the strongest anti-cancer activity in A375 melanoma cells and the least toxic effect on the non-cancerous keratocyte cell line (HaCaT). On the other hand, pure OCAL was shown to be more effective and safer than pure OCEIN. Post-treatment with any of the EVOO phenolic extracts (EVOO-PEs) enhanced the anti-cancer effect of the anti-cancerous drug dacarbazine (DTIC) applied in pre-treatment, while they did not compromise the viability of non-cancerous cells. The metastatic melanoma A375M cell line was almost unresponsive to the EVOO-PEs themselves, as well as to pure OCEIN and OCAL. Our results demonstrate that olive oils and/or their compounds may have a potentially beneficial effect on melanoma treatment. However, their usage can be detrimental or futile, especially in healthy cells, due to inadequately applied concentrations/combinations or the presence of resistant cells.

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“…(Cimmino et al, 2017), Diaporthella cryptica (Cimmino et al, 2018). Moreover, several studies have also reported tyrosol from the bioactive extracts of endophytic Colletotrichum (Colletotrichum gleosporoides, Colletotrichum crassipes) (Anisha and Radhakrishnan, 2017;Masi et al, 2018;Plotnikov and Plotnikova, 2020). However, the report of its isolation from C. coccodes is limited.…”

Section: Discussionmentioning

confidence: 99%

Isolation and Characterization of an Endophytic Fungus Colletotrichum coccodes Producing Tyrosol From Houttuynia cordata Thunb. Using ITS2 RNA Secondary Structure and Molecular Docking Study

Talukdar

Padhi

Kumar

et al. 2021

Front. Bioeng. Biotechnol.

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An endophytic fungus isolated from healthy leaf tissues of Houttuynia cordata Thunb., an ethnomedicinal plant of North East India, showed a considerable amount of antimicrobial activity. The ethyl acetate extract of the fungal culture filtrates displayed promising antimicrobial activity against a panel of clinically significant pathogens including Candida albicans, Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. Bioassay guided purification of the organic extract using column and thin layer chromatography yielded a pure homogenous compound which was identified using spectroscopic methods (essentially by 1H NMR and MS) as tyrosol, a well-known phenylethanoid present in several natural sources. Besides, molecular docking studies against tyrosyl tRNA synthetases (TyrRS) of S. aureus (PDB ID: 1JIL) and E. coli (PDB ID: 1VBM), and CYP45014α-lanosterol demethylase (CYP51) of C. albicans (PDB ID: 5FSA) revealed tyrosol has a strong binding affinity with the enzyme active site residues. The fungus was identified as Colletotrichum sp. and characterized by its genomic ITS rDNA and ITS2 sequences. Phylogenetic analyses showed clustering of our isolate with Colletotrichum coccodes. Species of Colletotrichum are also reported to be plant pathogens. Therefore, to confirm the endophytic lifestyle of the isolate, ITS2 RNA secondary structure study was undertaken. The result indicated our isolate exhibited differences in the folding pattern as well as in motif structures when compared to those of pathogenic C. coccodes. The findings indicated that endophytic fungi harboring H. cordata could be explored as a potent source of antimicrobial agents.

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Tyrosol as a Neuroprotector: Strong Effects of a “Weak” Antioxidant

Cited by 30 publications

References 142 publications

Medicinal Plants and Their Impact on the Gut Microbiome in Mental Health: A Systematic Review

Medicinal Plants and Their Impact on the Gut Microbiome in Mental Health: A Systematic Review

Extra Virgin Olive Oil Secoiridoids Modulate the Metabolic Activity of Dacarbazine Pre-Treated and Treatment-Naive Melanoma Cells

Isolation and Characterization of an Endophytic Fungus Colletotrichum coccodes Producing Tyrosol From Houttuynia cordata Thunb. Using ITS2 RNA Secondary Structure and Molecular Docking Study

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