Tyrosine kinase inhibitor, genistein, reduces renal inflammation and injury in streptozotocin-induced diabetic mice

Genistein ameliorates cardiac inflammation and oxidative stress in streptozotocin-induced diabetic cardiomyopathy in rats

“…Guo et al, study also demonstrated that oral administration of GNST reduced the incidence as well as increased the time to onset of diabetes mellitus in genetically susceptible female mice when fed a soy-and alfalfa-free 5K96 diet [36]. The hypoglycemic effects of GNST as observed in the present study concur with previously published reports [32][33][34][35][36][37].…”

“…The molecular basis for protection afforded by genistein was also studied. It has been reported that the soya phytoestrogen GNST reduces hyperglycemia and islet cell loss in alloxan-induced diabetic male Sprague-Dawley rats [32] and in STZ-induced diabetic male C57BL/6J mice [33,34]. In addition, supplementation of GNST increased the plasma insulin level and decreased the HbA1c level in STZ-induced diabetic male Sprague-Dawley rats [35].…”

Adenosine A2A receptor modulates vascular response in soluble epoxide hydrolase-null mice through CYP-epoxygenases and PPARγ

“…[5][6][7][8] suggests that this relaxation depends on A 2A AR via CYP-epoxygenases leading to EETs formation. Therefore, we were able to block CGS 21680-induced vascular relaxation with 14,15-EEZE (EET receptor antagonist) in sEH Ϫ/Ϫ mouse aortas (Fig.…”

“…Inhibition of sEH causes EETs to accumulate and be retained for longer periods after they are formed (9). Some reports provide further evidence that sEH inhibition may be an effective approach for the treatment of hypertension and diseases associated with vascular inflammation (7,8,18,47,61). Also, the targeted disruption of the sEH gene in male mice lowers systolic blood pressure (51).…”

The effects of genistein supplementation on fructose induced insulin resistance, oxidative stress and inflammation

“…Genistein is reported to act as an antioxidant by chelating metals [20], and to ameliorate oxidative stress in STZ infected mice [21]. According to Zora Djuric [22], a decrease of about 20 % in plasma 8-isoprostane level was observed when textured soy bean containing 56 mg soy isoflavones was consumed by healthy volunteers.…”