The effects of genistein supplementation on fructose induced insulin resistance, oxidative stress and inflammation

İncir, Said; Bolayırlı, Murat; Inan, Onur; Aydın, Mehmet; Bilgin, İsmail Ahmet; Sayan, İsmet; Eşrefoğlu, Mukaddes; Seven, Arzu

doi:10.1016/j.lfs.2016.06.014

Cited by 45 publications

(24 citation statements)

References 28 publications

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“…Oxidative stress also involves in the development of IBD and colitis-associated colorectal cancer and antioxidant agents as pharmacological targets for anti-IBD drugs [ 16 , 17 ]. Although we failed to investigate colonic antioxidant status in this study, genistein has been widely demonstrated to exhibit antioxidant function in inflammatory diseases [ 15 , 18 ].…”

Section: Discussionmentioning

confidence: 99%

Genistein improves inflammatory response and colonic function through NF-κB signal in DSS-induced colonic injury

Zhang

Zhao

et al. 2017

Oncotarget

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This study aimed to investigate the protective potential of genistein in dextran sulfate sodium (DSS)-induced colonic injury in vitro and in vivo models. The results showed that DSS exposure caused growth suppression, colonic injury, inflammation, and barrier dysfunction in mice. Dietary genistein alleviated DSS-caused colonic injury via reducing colonic weight, rectal bleeding, and diarrhea ratio. Meanwhile, genistein reduced colonic inflammatory response via downregulating cytokines expression and improved colonic permeability and barrier in DSS-challenged mice. In Caco-2 cells, genistein improved cell viability and cellular permeability and inhibited DSS-induced activation of TLR4/NF-κB signal. In conclusion, genistein alleviated DSS-caused colonic injury, inflammation, and gut dysfunction, which might be associated with the TLR4/NF-κB signal.

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Section: Discussionmentioning

confidence: 99%

Genistein improves inflammatory response and colonic function through NF-κB signal in DSS-induced colonic injury

Zhang

Zhao

et al. 2017

Oncotarget

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“…Current studies have shown that consumption of fructose changes the lipid profile . Incir et al noticed an increase in serum triglyceride, TC, and LDL levels and a decrease in HDL levels in the fructose‐treated group. Zhao et al observed that administration of fructose with liquid, elevated triglyceride, TC, and LDL levels but nonsignificantly decreased the HDL levels.…”

Section: Discussionmentioning

confidence: 99%

Dipeptidyl peptidase‐4 inhibition prevents cell death via extrinsic and intrinsic apoptotic pathways in rat pancreas with insulin resistance

Nephan

Coşkun

Bolkent

2018

Cell Biochemistry & Function

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The study aims to evaluate the effect of saxagliptin, a specific inhibitor of dipeptidyl peptidase-4 enzymes, on body weight gain, lipid profiles, and cell death through apoptosis in rats with insulin resistance (IR). Male adult Sprague-Dawley rats (n = 32) were divided into 4 groups: control (Ctrl), IR, saxagliptin control, and IR treated with saxagliptin(IR + S). Insulin resistance was induced by 10% fructose in the drinking water for 8 weeks. Saxagliptin (10 mg/kg/day) was administrated by oral gavage for 2 weeks. Biochemical parameters were measured spectrophotometrically. Peptides were determined by the streptavidin-biotin-peroxidase method. Although the amount of food and liquid consumed are inversely proportional, the calories received are almost equal between both Ctrl and IR groups, as well as IR and IR + S groups. Increased homeostasis model assessment for insulin resistance, HOMA-β, triglycerides, and very low-density lipoprotein in the IR group were comparatively decreased by saxagliptin administration. The area percentage of caspase-3 and apoptotic peptidase activating factor-1 immunopositive cells in the IR + S group decreased compared with the IR group. Similarly, the percentages of caspase-8 and -9 immunopositive cells in the IR group were higher than the IR + S group. It was observed that the percentage of poly (ADP-ribose) polymerase-1 immunopositive cells was increased in the IR + S group compared with the IR group. Thus, saxagliptin may prevent IR-induced apoptotic cell death and regulate impaired homeostasis model assessment for insulin resistance and serum lipid levels.

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“…In particular, the number of monocytes and neutrophils increased after GEN treatment. GEN can reportedly relieve the inflammatory reaction induced by fructose and decrease the level of 8-isoprostaglandin and TNF- α in the liver [34]. This leads us to further explore the effect of GEN on acquired immunity of LBB hens.…”

Section: Discussionmentioning

confidence: 99%

RNA Expression Profile and Alternative Splicing Signatures of Genistein-Treated Breeder Hens Revealed by Hepatic Transcriptomic Analysis

Shi

Jiang

Ning

et al. 2019

Oxidative Medicine and Cellular Longevity

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Little information has been available about the influence of dietary genistein (GEN) on hepatic transcriptome of laying broiler breeder (LBB) hens. The study is aimed at broadening the understanding of RNA expression profiles and alternative splicing (AS) signatures of GEN-treated breeder hens and thereby improving laying performance and immune function of hens during the late egg-laying period. 720 LBB hens were randomly allocated into three groups with supplemental dietary GEN doses (0, 40 mg/kg, and 400 mg/kg). Each treatment has 8 replicates of 30 birds. Dietary GEN enhanced the antioxidative capability of livers, along with the increased activities of glutathione peroxidase and catalase. Furthermore, it improved lipid metabolic status and apoptotic process in the liver of hens. 40 mg/kg dietary GEN had the better effects on improving immune function and laying performance. However, transcriptome data indicated that 400 mg/kg dietary GEN did negative regulation of hormone biosynthetic process. Also, it upregulated the expressions of EDA2R and CYR61 by the Cis regulation of neighbouring genes (lncRNA_XLOC_018890 and XLOC_024242), which might activate NF-κB and immune-related signaling pathway. Furthermore, dietary GEN induced AS events in the liver, which also enriched into immune and metabolic process. Therefore, the application of 40 mg/kg GEN in the diet of breeder hens during the late egg-laying period can improve lipid metabolism and immune function. We need to pay attention to the side-effects of high-dose GEN on the immune function.

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The effects of genistein supplementation on fructose induced insulin resistance, oxidative stress and inflammation

Cited by 45 publications

References 28 publications

Genistein improves inflammatory response and colonic function through NF-κB signal in DSS-induced colonic injury

Genistein improves inflammatory response and colonic function through NF-κB signal in DSS-induced colonic injury

Dipeptidyl peptidase‐4 inhibition prevents cell death via extrinsic and intrinsic apoptotic pathways in rat pancreas with insulin resistance

RNA Expression Profile and Alternative Splicing Signatures of Genistein-Treated Breeder Hens Revealed by Hepatic Transcriptomic Analysis

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