Typing of<i>Propionibacterium acnes</i>: a review of methods and comparative analysis

Yang, Yu‐Shih; Champer, Jackson; Garbán, Hermes; Kim, J.

doi:10.1111/bjd.13667

Cited by 32 publications

(21 citation statements)

References 51 publications

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“…Many other phylotypes are of potential interest, since they have been recently shown to have differing disease associations, including for acne vulgaris [28, 29, 39]. We are currently characterizing the full proteome of several of these phylotypes.…”

Section: Discussionmentioning

confidence: 99%

Analysis of the surface, secreted, and intracellular proteome of Propionibacterium acnes

Yang

Champer

Kim

2015

EuPA Open Proteomics

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Propionibacterium acnes , plays an important role in acne vulgaris and other diseases. However, understanding of the exact mechanisms of P. acnes pathogenesis is limited. Few studies have investigated its proteome, which is essential for vaccine development. Here, we comprehensively investigate the proteome of P. acnes strain ATCC 6919, including secreted, cell wall, membrane, and cytosolic fractions in three types of growth media. A total of 531 proteins were quantified using an Orbitrap mass spectrometer and bioinformatically categorized for localization and function. Several, including PPA1939, a highly expressed surface and secreted protein, were identified as potential vaccine candidates.

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Section: Discussionmentioning

confidence: 99%

Analysis of the surface, secreted, and intracellular proteome of Propionibacterium acnes

Yang

Champer

Kim

2015

EuPA Open Proteomics

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“…Recently, several studies found that certain phylotypes (IA‐2 with plasmid factor, IB‐1, I‐C) of C. acnes were more commonly associated with acne, while others (II‐ribotype 6, III) were exclusively associated with healthy skin . Therefore, these phylotypes may be a factor in the pathogenesis of acne.…”

Section: Methodsmentioning

confidence: 99%

“…An in vitro study revealed that acne‐associated phylotypes induce high T helper cell (Th)1 and Th17 responses, while healthy skin‐associated phylotypes induce relatively low Th1 and Th17 responses, but a high interleukin (IL)‐10 anti‐inflammatory response . This suggests that the healthy skin‐associated C. acnes phylotypes may be of use in a topical probiotic treatment or preventative regimen, designed to replace acne‐associated and other potentially opportunistic phylotypes . Such a targeted strategy utilizing the same species of bacteria that share an ecological niche may be a more effective approach than using other skin or especially gut commensals, by allowing faster and longer‐lasting improvements to the skin microbiota.…”

Section: Methodsmentioning

confidence: 99%

“…45 Recently, several studies found that certain phylotypes (IA-2 with plasmid factor, IB-1, I-C) of C. acnes were more commonly associated with acne, while others (II-ribotype 6, III) were exclusively associated with healthy skin. [46][47][48][49][50] Therefore, these phylotypes may be a factor in the pathogenesis of acne. An in vitro study revealed that acne-associated phylotypes induce high T helper cell (Th)1 and Th17 responses, while healthy skin-associated phylotypes induce relatively low Th1 and Th17 responses, but a high interleukin (IL)-10 antiinflammatory response.…”

Section: Acne Vulgarismentioning

confidence: 99%

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Changing our microbiome: probiotics in dermatology

et al. 2019

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Summary Background Commensal bacteria are a major factor in human health and disease pathogenesis. Interest has recently expanded beyond the gastrointestinal microbiome to include the skin microbiome and its impact on various skin diseases. Objectives Here we present current data reviewing the role of the microbiome in dermatology, considering both the gut and skin microflora. Our objective was to evaluate whether the clinical data support the utility of oral and topical probiotics for certain dermatological diseases. Methods The PubMed and ClinicalTrials.gov databases were searched for basic science, translational research and clinical studies that investigated differences in the cutaneous microbiome and the impact of probiotics in patients with atopic dermatitis, acne vulgaris, psoriasis, chronic wounds, seborrhoeic dermatitis and cutaneous neoplasms. Results Few clinical trials exist that explore the utility of probiotics for the prevention and treatment of dermatological diseases, with the exception of atopic dermatitis. Most studies investigated oral probiotic interventions, and of those utilizing topical probiotics, few included skin commensals. In general, the available clinical trials yielded positive results with improvement of the skin conditions after probiotic intervention. Conclusions Oral and topical probiotics appear to be effective for the treatment of certain inflammatory skin diseases and demonstrate a promising role in wound healing and skin cancer. However, more studies are needed to confirm these results. What's already known about this topic? The microbiome plays a role in human health and disease pathogenesis. Probiotics can manipulate the host microbiome and may confer health benefits for patients. Research to date has already begun to explore the utility of oral and topical probiotics for certain dermatological diseases. What does this study add? This review presents basic science and clinical trial data to support the role of the gut and skin microbiome in dermatology. Current data are reviewed on the use of probiotics in the prevention and treatment of skin diseases, including atopic dermatitis, acne vulgaris, psoriasis, seborrhoeic dermatitis, chronic wounds and cutaneous neoplasms. Future probiotic interventions are proposed.

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“…Recent years have experienced an explosion of sequence‐based typing methods for P. acnes . In this issue of the BJD Dr Yang Yu and coworkers present a timely review and comparison of these methods. Application of some of these methods may provide new insight into our complex relationship with P. acnes and pave the way for new prevention and treatment strategies.…”

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confidence: 99%